The Application of Computer Design Tools in Building and HVAC System Design

Abstract

Designers are being increasingly pressurised to design buildings with high standards of energy e1ciency, performance and comfort. Computers are seen as an important modern design tool that can help lighten some of the designers' burdens. A myriad of computer applications already exists, ranging from complex 4nite-element applications to simple electronic nomographs. New development in this 4eld tends to be in the areas of integrated building design and knowledge-based systems.Researchers and scientists can develop tools with the potential to greatly enhance the quality of buildings. These tools will however fail if they are not widely accepted and used by designers. Only a few building designers currently exploit the full potential of computer design tools. The general use of computers seems to be restricted to CAD and steady state calculations. This can mainly be attributed to the complexity of, and time required for using the existing tools.

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

“…Although QC and isoQC exhibit nearly identical substrate specificity in vitro, data from knockout mice indicate that QC and isoQC have preference for different peptides and proteins 4 . Since important substrates, such as CCL2, MCP-1, and amyloid-β, have been identified for QC/isoQC, QC/isoQC are regarded as potential therapeutic targets for inflammatory disease, Huntington's disease and Alzheimer disease 5,6 . Although studies suggest that QC/isoQC may be a risk factor for chronic lymphocytic leukemia and thyroid carcinomas 7 , it is largely unknown whether QC/isoQC, especially isoQC, play any role in cancer development, especially cancer immune surveillance.…”