The application of near-infrared spectroscopy in oxygen therapy for premature infants

Yang, Xi; Lei, Xiaoping; Zhang, Lianyu; Zhang, Lingping; Dong, Wei

doi:10.1080/14767058.2018.1489535

Cited by 13 publications

(24 citation statements)

References 20 publications

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“…Regional tissue saturation by Near Infrared Spectroscopy (NIRS) is another noninvasive method which is gaining popularity. There is accumulating information based on NIRS studies especially in the fetal to neonatal transition and postnatal adaptation, and also on longterm safety and impact [17][18][19].…”

Section: Seminars In Fetal Andmentioning

confidence: 99%

Oxygen metabolism and oxygenation of the newborn

Andresen

Saugstad

2020

Seminars in Fetal and Neonatal Medicine

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The premature infant is to some extent protected from hypoxia, however defense against hyperoxia is poorly developed. The optimal assessment of oxygenation is to measure oxygen delivery and extraction. At the bedside PaO 2 and SpO 2 are approximations of oxygenation at the tissue level. After birth asphyxia it is crucial to know whether or not to give oxygen supplementation, when, how much, and for how long. Oxygen saturation targets in the delivery room have been studied, but the optimal targets might still be unknown because factors like gender and delayed cord clamping influence saturation levels. However, SpO 2 > 80% at 5 min of age is associated with favorable long term outcome in preterm babies.Immature infants most often need oxygen supplementation beyond the delivery room. Predefined saturation levels, and narrow alarm limits together with the total oxygen exposure may impact on development of oxygen related diseases like ROP and BPD. Hyperoxia is a strong trigger for genetic and epigenetic changes, contributing to the development of these conditions and perhaps lifelong changes.

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Section: Seminars In Fetal Andmentioning

confidence: 99%

Oxygen metabolism and oxygenation of the newborn

Andresen

Saugstad

2020

Seminars in Fetal and Neonatal Medicine

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“…NIRS has been used in several studies to evaluate cerebral oxygenation and, to less extent, renal, hepatic, and splanchnic oxygenation 10–14 . However, although the penetration depth of 1.0−1.5 cm of the NIRS light 15 is appropriate for the study of the oxygenation of the lung parenchyma in preterm infants, this possible use has been poorly investigated 16 …”

Section: Introductionmentioning

confidence: 99%

Measurement of lung oxygenation by near‐infrared spectroscopy in preterm infants with respiratory distress syndrome: A proof‐of‐concept study

Dani

Ciarcià

Miselli

et al. 2022

Pediatric Pulmonology

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Introduction: Noninvasive markers more accurate than FiO 2 would be useful to assess the severity of RDS and guide its treatment. Our aim was to assess for the first time the possibility of continuously monitoring lung oxygenation (rSO 2 L) by near-infrared spectroscopy (NIRS) and to evaluate whether rSO 2 L correlates with other oxygenation indices and RDS severity. Methods:We carried out this proof-of-concept study on 20 preterm infants with RDS requiring noninvasive respiratory support. Patients were continuously studied for 24 h by NIRS and rSO 2 L was correlated with SpO 2 /FiO 2 ratio, a/APO 2 , and O.I. Results:The overall value of rSO 2 L was 80.1 ± 6.2%, without significant differences between the right and left hemithorax (80.2 ± 6.7 vs. 80.0 ± 5.7%; p = 0.869). Mean values of total, right, and left rSO 2 L did not significantly change during the 24-h study period. Linear regression analysis demonstrated a significant positive relationship between total rSO 2 L and SpO 2 /FiO 2 ratio (p < 0.001) and a/APO 2 (p = 0.040), and a negative relationship between total rSO 2 L and O.I. (r = −0.309; p = 0.022).Conclusions: Continuous monitoring of rSO 2 L by NIRS in preterm infants with RDS is feasible and safe. The correlation of rSO 2 L with other indices of oxygenation and RDS severity supports the accuracy and reliability of this measurement.

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“…Although NIRS has been commercially available as a clinical device since the early 1990s, there has been limited research on the use of NIRS to monitor respiratory function. A previous study found a positive correlation between pulmonary regional oxygen saturation (rSO 2 ) using NIRS and arterial partial pressure of oxygen (PaO 2 ) obtained from a blood gas analysis as a gold standard [ 34 ]. A wearable NIRS sensor provides several advantages over conventional methods for monitoring respiratory function.…”

Section: Discussionmentioning

confidence: 99%

Optical Monitoring of Breathing Patterns and Tissue Oxygenation: A Potential Application in COVID-19 Screening and Monitoring

Mah

Nguyen

Zadeh

et al. 2022

Sensors

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The worldwide outbreak of the novel Coronavirus (COVID-19) has highlighted the need for a screening and monitoring system for infectious respiratory diseases in the acute and chronic phase. The purpose of this study was to examine the feasibility of using a wearable near-infrared spectroscopy (NIRS) sensor to collect respiratory signals and distinguish between normal and simulated pathological breathing. Twenty-one healthy adults participated in an experiment that examined five separate breathing conditions. Respiratory signals were collected with a continuous-wave NIRS sensor (PortaLite, Artinis Medical Systems) affixed over the sternal manubrium. Following a three-minute baseline, participants began five minutes of imposed difficult breathing using a respiratory trainer. After a five minute recovery period, participants began five minutes of imposed rapid and shallow breathing. The study concluded with five additional minutes of regular breathing. NIRS signals were analyzed using a machine learning model to distinguish between normal and simulated pathological breathing. Three features: breathing interval, breathing depth, and O2Hb signal amplitude were extracted from the NIRS data and, when used together, resulted in a weighted average accuracy of 0.87. This study demonstrated that a wearable NIRS sensor can monitor respiratory patterns continuously and non-invasively and we identified three respiratory features that can distinguish between normal and simulated pathological breathing.

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The application of near-infrared spectroscopy in oxygen therapy for premature infants

Abstract: NIRS objectively reflects the changes in oxygenation in the lung tissue. This study provides evidence for the clinical application of NIRS.

Cited by 13 publications

References 20 publications

Oxygen metabolism and oxygenation of the newborn

Oxygen metabolism and oxygenation of the newborn

Measurement of lung oxygenation by near‐infrared spectroscopy in preterm infants with respiratory distress syndrome: A proof‐of‐concept study

Optical Monitoring of Breathing Patterns and Tissue Oxygenation: A Potential Application in COVID-19 Screening and Monitoring

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