The application of the supported liquid membrane and molecularly imprinted polymers as solid acceptor phase for selective extraction of biochanin A from urine

Chrzanowska, Anna M.; Díaz‐Álvarez, Myriam; Wieczorek, Piotr; Poliwoda, Anna; Martín‐Esteban, Antonio

doi:10.1016/j.chroma.2019.04.005

Cited by 27 publications

(6 citation statements)

References 24 publications

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“…The organic solvents strongly influence the configuration of the polymer network, consequently changing the pore volume and surface area. 41 Loading of solvents was done by using two solvents, which were isopropanol and water. To have better interaction between SLX and MIP, the effect of the polarity of the loading solvent must be considered.…”

Section: Optimization Of the Mispe Conditionmentioning

confidence: 99%

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Suryana

Mutakin

Rosandi

et al. 2021

Polymers for Advanced Techs

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A molecular imprinted polymer (MIP) was computationally designed and synthesized for the selective extraction of salmeterol xinafoate (SLX) from human serum. In this study, semi-empirical PM3 calculations were used to find a suitable functional monomer (FM), the ratio of template (T) to FM, and types of crosslinkers. MIPs were synthesized with 2-hydroxyethyl methacrylate (HEMA) with T:FM mol ratios of 1:6 and 1:4 and ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as a crosslinker. On the basis of computational and experimental results, HEMA and TRIM in the mol ratio 1:6 of T-FM (MIP3) were found to be the best choices of FM and crosslinker, respectively. These polymers were then used as a selective sorbent to develop a molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with UV detection for the determination of SLX in serum. The extraction ability of MIP3 was excellent with a recovery of 92.17% ± 2.66% of SLX in spiked serum, and 91.15% ± 1.12% when SLX was spiked as a mixture with another analogous structure. By comparing the performance of the synthesized sorbent with a C-18 cartridge with a recovery of 79.11% ± 2.96%, it was determined that MIP had better performance over the latter. On the basis of these results, the imprinted receptor MIPs, especially MIP 3, can be applied for the direct extraction of SLX in clinical analysis.

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Section: Optimization Of the Mispe Conditionmentioning

confidence: 99%

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Suryana

Mutakin

Rosandi

et al. 2021

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…Modification of the imprinting system can also increase the binding efficiency of the MIPs towards the target flavonoids. Recently, Chrzanowska et al [ 39 ] reported that the binding selectivity of the MIPs synthesized using 2-(dimethylamino) ethyl methacrylate (DEM) as monomers was 5 folds higher than that synthesized using methacrylic acid (MAA) as monomers. Li et al [ 40 ] reported that fabrication of binary MIPs (Bi-MIPs) using MAA and AM as binary functional monomers was also an efficient way to enhance the adsorption performance of the MIPs (the imprinting factor (IF) of the Bi-MIPs was 1.54 times to the ordinary MIPs).…”

Section: Methods For Preparing Mips Of Target Flavonoidsmentioning

confidence: 99%

“…(2) Recently, the combination of various technologies with MIPs towards flavonoids is the direction of future scientific development. For example, integration of MIP-based SPE with hollow fiber supported liquid membrane extraction (HF-sLME) could achieve selective extraction of biochanin A in urine [ 39 ]. The combination of MIP-based SPE with other methods might exhibit outstanding merits (e.g., enhancing selective extraction ability, effectively facilitating sample analysis and strengthening the ability to connect with instruments preeminently) for extraction of flavonoids from natural products or biological samples.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective

Yang

Shen

2022

Molecules

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The separation and detection of flavonoids from various natural products have attracted increasing attention in the field of natural product research and development. Depending on the high specificity of molecularly imprinted polymers (MIPs), MIPs are proposed as efficient adsorbents for the selective extraction and separation of flavonoids from complex samples. At present, a comprehensive review article to summarize the separation and purification of flavonoids using molecular imprinting, and the employment of MIP-based sensors for the detection of flavonoids is still lacking. Here, we reviewed the general preparation methods of MIPs towards flavonoids, including bulk polymerization, precipitation polymerization, surface imprinting and emulsion polymerization. Additionally, a variety of applications of MIPs towards flavonoids are summarized, such as the different forms of MIP-based solid phase extraction (SPE) for the separation of flavonoids, and the MIP-based sensors for the detection of flavonoids. Finally, we discussed the advantages and disadvantages of the current synthetic methods for preparing MIPs of flavonoids and prospected the approaches for detecting flavonoids in the future. The purpose of this review is to provide helpful suggestions for the novel preparation methods of MIPs for the extraction of flavonoids and emerging applications of MIPs for the detection of flavonoids from natural products and biological samples.

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“…To evaluate the selectivity, we calculated the factor of selectivity α according to Equation 2 (Chrzanowska et al, 2015b). The molecular imprinting materials for analysis of phytoestrogens have been investigated, and the topic has been extensively studied by Chrzanowska et al (2015aChrzanowska et al ( , 2019.…”

Section: Selectivity Of Prepared Polymeric Layersmentioning

confidence: 99%

Molecularly imprinted polymers and capillary electrophoresis for sensing phytoestrogens in milk

Bezděková

Vlčnovská

Zemánková

et al. 2020

Journal of Dairy Science

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Dairy cow feed contains, among other ingredients, soybeans, legumes, and clover, plants that are rich in phytoestrogens. Several publications have reported a positive influence of phytoestrogens on human health; however, several unfavorable effects have also been reported. In this work, a simple, selective, and ecofriendly method of phytoestrogen isolation based on the technique of noncovalent molecular imprinting was developed. Genistein was used as a template, and dopamine was chosen as a functional monomer. A layer of molecularly imprinted polymers was created in a microtitration well plate. The binding capability and selective properties of obtained molecularly imprinted polymers were investigated. The imprinted polymers exhibited higher binding affinity toward chosen phytoestrogen than did the nonimprinted polymers. A selectivity factor of 6.94 was calculated, confirming satisfactory selectivity of the polymeric layer. The applicability of the proposed sensing method was tested by isolation of genistein from a real sample of bovine milk and combined with micellar electrokinetic capillary chromatography with UV-visible detection

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The application of the supported liquid membrane and molecularly imprinted polymers as solid acceptor phase for selective extraction of biochanin A from urine

Cited by 27 publications

References 24 publications

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective

Molecularly imprinted polymers and capillary electrophoresis for sensing phytoestrogens in milk

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