The architectures and surface behavior of highly branched molecules

Peleshanko, Sergiy; Tsukruk, Vladimir V.

doi:10.1016/j.progpolymsci.2008.01.003

Cited by 174 publications

(161 citation statements)

References 278 publications

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“…Brush-like polymers can be designed to contain flexible side-chain polymers, such as poly(methyl methacrylate), poly(styrene), elastin-like polypeptides, and PEG [204][205][206].…”

Section: Cylindrical Brushesmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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Abstract:Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics has helped to establish these polypeptide-based constructs as polymeric nanomedicines for different applications, such as disease treatment and diagnostics. Herein, we provide an overview of the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research towards clinical applications.

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“…Brush-like polymers can be designed to contain flexible side-chain polymers, such as poly(methyl methacrylate), poly(styrene), elastin-like polypeptides, and PEG [204][205][206].…”

Section: Cylindrical Brushesmentioning

confidence: 99%

Peptide-Based Polymer Therapeutics

2014

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“…1,2 Crystalline main chain with amorphous side chain [3][4][5][6][7][8][9][10][11] comb polymers and amorphous main chain with crystalline side chain [12][13][14][15][16][17][18] ones have been studied extensively and reviewed in terms of their chemistry 19,20 and physical properties. 21 The movement of crystalline segments is variably inhibited by the amorphous portion; thus, formation of various segregated structures is often observed from similar materials. The 'crystalline-crystalline' comb polymers, [22][23][24][25] especially those with aromatic main chain polymers, [26][27][28][29] are of interest because packing of the bulky aromatic polymer main chain can be changed by varying the crystallinity of side chains.…”

Section: Introductionmentioning

confidence: 99%

Direct condensation polymerization of N-alkylated p-aminobenzoic acid and packing of rigid-rod main chains with flexible side chains

Shibasaki

Abe

Sato

et al. 2010

Polym J

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Direct condensation polymerization of N-alkylated p-aminobenzoic acid, in which methyl, propyl, butyl, pentyl, heptyl, octyl and heptadecyl substituents were used as the alkyl group, was performed using hexachloroethane, triphenylphosphine and pyridine as condensation reagents. Pale-yellow N-alkylated poly(p-benzamide) (PABA n ) polymers, where n is the number of carbon atoms of the alkyl side chain, were obtained in 46-87% yields with an inherent viscosity of 0.06-0.65 per 100 ml g À1 (conc. H 2 SO 4 , 30 1C). The structures of PABA n were identified using infrared, nuclear magnetic resonance and elemental analysis. PABA n with long alkyl side chains (n43) showed good solubility in chloroform, as well as conc. H 2 SO 4 and m-cresol. The glass transition temperature (T g ) of PABA n measured by differential scanning calorimetry gradually decreased with an increase in the length of the alkyl group. The endothermic peak corresponding to melting was observed for PABA n with n¼3, 4, 5 and 17 on DSC profiles. The wide-angle powder X-ray scattering of the polymer samples indicated that PABA n polymers with n¼0, 1, 3, 4, 5 and 17 were crystalline polymers. X-ray scattering profiles showed PABA n with n¼3, 4 and 5 crystallized in an orthorhombic lattice, whereas PABA 1 crystallized in a monoclinic lattice. PABA 17 crystallized in hexagonal packing at the long side chain with an interplanar spacing of 4.2 Å .

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“…1 In particular, the control of the number of the branches allows fine-tuning physical properties and processing conditions. In addition to regular dendrimers, a wide variety of highly branched structures have been designed being one of the simplest graft polymers also called molecular brush or comb-like polymers.…”

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confidence: 99%

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

Luzon

Corrales

Catalina

et al. 2010

J. Polym. Sci. A Polym. Chem.

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A series of amphiphilic triblock copolymers, poly [oligo(ethylene glycol) methacrylate] x -block-poly(e-caprolactone)-block-poly[oligo(ethylene glycol) methacrylate] x , POEGMA Co (x), were synthesized. Formation of hydrophobic domains as cores of the micelles was studied by fluorescence spectroscopy. The critical micelle concentrations in aqueous solution were found to be in the range of circa 10 À6 M. A novel methodology by modulated temperature differential scanning calorimetry was developed to determine critical micelle temperature. A significant concentration dependence of cmt was found. Dynamic light scattering measurements showed a bidispersed size distribution.The micelles showed reversible dispersion/aggregation in response to temperature cycles with lower critical solution temperature between 75 and 85 C. The interplay of the two hydrophobic and one thermoresponsive macromolecular chains offers the chance to more complex morphologies. V C 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: [4909][4910][4911][4912][4913][4914][4915][4916][4917][4918][4919][4920][4921] 2010

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The architectures and surface behavior of highly branched molecules

Cited by 174 publications

References 278 publications

Peptide-Based Polymer Therapeutics

Peptide-Based Polymer Therapeutics

Direct condensation polymerization of N-alkylated p-aminobenzoic acid and packing of rigid-rod main chains with flexible side chains

Hierarchically organized micellization of thermoresponsive rod‐coil copolymers based on poly[oligo(ethylene glycol) methacrylate] and poly(ε‐caprolactone)

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