The Arg72Pro Polymorphism of TP53 in Croatian Population

Zorić, Arijana; Horvat, Anđela; Balija, Melita; Slade, Neda

doi:10.5562/cca1866

Cited by 4 publications

(3 citation statements)

References 36 publications

(54 reference statements)

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“…Distributions of p53 Arg72Pro genotypes in our healthy control group are almost identical to those reported for the Croatia, Germany, Italy, and other nearby countries, comparable in ethnicity and latitude [37][38][39][40][41]. Chi-square or Fischer exact tests did not reveal association between the CRC risk and p53 Arg72Pro polymorphism.…”

Section: Product Of Pcr-rflp Analysis Of Egf A61g (Left) and P53 Arg7supporting

confidence: 58%

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

et al. 2014

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AbstractDuring the transformation process single nucleotide polymorphisms (SNPs) of key genes, such as p53 Arg72Pro or EGF A61G, may mediate various cellular processes. These variants may be associated with colorectal cancer risk (CRC), but conflicting findings have been reported. The purpose of this study was to determine the association of the SNPs in 5′ UTR of EGF A61G and p53 Arg72Pro and CRC in the Slovak population. The present case-control study was carried out in 173 confirmed CRC patients and 303 healthy subjects. Genotyping was performed by PCR-RFLP methods. Significant association was observed between age and CRC risk (p=0.001). Lower CRC risk was seen in younger patients carrying genotype p53 Arg72Pro (0.14; 95% CI 0.02–0.99, p=0.049). Gender-stratified analysis showed a significant inverse association of the polymorphism EGF G61G with CRC risk (0.48; 95% CI 0.2–0.9, p=0.04) only in male patients. Tumour site genotype distribution revealed that female patients with localized colon cancer were significantly associated with p53 Pro72Pro genotype (4.0; 95% CI 1.27–12.7, p=0.04) whereas the cancer of rectosigmoid junction was associated with the EGF G61G genotype (4.5; 95% CI 1.2–16.97, p=0.02). Combination of p53 Arg72Pro or EGF A61G polymorphisms were not associated with CRC risk by using logistic regression.

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Section: Product Of Pcr-rflp Analysis Of Egf A61g (Left) and P53 Arg7supporting

confidence: 58%

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

et al. 2014

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“…Our finding is similar to the findings of Tian et al [49] where there was an association between the cancer risk in Asian populations and TP53 Arg72Pro polymorphism. Zoric et al [50] also demonstrated that there was a positive association between cancer risk in ethnicity and p53 polymorphism Arg72Pro. The substantial ethnicity differences in Arg72Pro polymorphism may result from a genetic background and some influential environmental conditions such as sunlight.…”

Section: Discussionmentioning

confidence: 95%

The Relationship Between Leukemia and TP53 Gene Codon Arg72Pro Polymorphism: Analysis in a Multi-Ethnic Population

et al. 2020

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Aim: Many studies have analyzed the relationship between Arg72Pro polymorphism of TP53 and leukemia; nevertheless, the findings continue to be indeterminate. We, therefore, performed an updated meta-analysis in multi-ethnic groups using specialized software for genome-wide association studies meta-analysis. Materials & methods: PubMed, EMBASE and Google Scholar were searched up to October 2018. An odds ratio (OR) with the corresponding 95% CI was used to evaluate the strength in the association. Results: This meta-analysis included 16 studies with 2337 cases and 9494 controls. In the overall population, significant relationship between Arg72Pro polymorphism of TP53 and leukemia susceptibility was found in two genetic models (recessive model: OR = 1.276, 95% CI = 1.102–1.476; p = 0.01; overdominant model: OR = 0.891, 95% CI = 0.802–0.988; p = 0.03). In stratified studies with ethnicity, a significant association was found in five ethnic groups, including Chinese, Americans, Africans, Japanese and Indians. Conclusion: We demonstrated that an association exist between leukemia risk and TP53 gene codon Arg72Pro polymorphism in the recessive and overdominant genetic models. Also, our findings show that the TP53 Arg72Pro polymorphism may influence leukemia development in different populations.

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“…It contains conformationally flexible motifs that bind transcriptional coactivator p300, involved in p53 activation through acetylation [46]. Furthermore, the PRD is important for regulating p53-mediated apoptosis [47,48]; rs1042522 (p53 p.R72P) is a common polymorphism in the PRD whose allele frequency differs in populations worldwide [49] and was recently associated with the CRC risk among specific ethnic groups according to a meta-analysis [50].…”

Section: Structure Of the P53 Protein Isoformsmentioning

confidence: 99%

p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies

Horvat

Tadijan

Vlašić

et al. 2021

Cancers

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The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing, generating multiple isoforms. The resulting isoforms have important roles in carcinogenesis, while their expression is dysregulated in several human tumors including colorectal carcinoma, which makes them potential targets in cancer treatment. Their activities arise, at least in part, from the ability to form tetramers that bind to specific DNA sequences and activate the transcription of target genes. In this review, we summarize the current understanding of the biological activities and regulation of the p53/p73 isoforms, highlighting their role in colorectal tumorigenesis. The analysis of the expression patterns of the p53/p73 isoforms in human cancers provides an important step in the improvement of cancer therapy. Furthermore, the interactions among the p53 family members which could modulate normal functions of the canonical p53 in tumor tissue are described. Lastly, we emphasize the importance of clinical studies to assess the significance of combining the deregulation of different members of the p53 family to define the outcome of the disease.

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The Arg72Pro Polymorphism of TP53 in Croatian Population

Cited by 4 publications

References 36 publications

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

The Relationship Between Leukemia and TP53 Gene Codon Arg72Pro Polymorphism: Analysis in a Multi-Ethnic Population

p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies

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