The Armed Services Blood Program

Rentas, Francisco J.; Lincoln, David A; Harding, Aaron; Maas, P.M. van der; Giglio, J M; Fryar, Ronny; Elder, Kathleen; Fahie, Roland; Whitlock, Kathleen; Vinluan, Jerome; Gonzales, Richard

doi:10.1097/ta.0b013e31827546e4

Cited by 21 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Recent military conflicts have increased the need for multiple blood product components for management of major traumatic haemorrhage in resourcepoor settings. [6][7][8][9] This has driven the development of platelet transfusion products that have longer shelf-lives and are easier to carry, store and use in conflict zones. 10 Lyophilised (freeze-dried) platelet products offer substantial benefits in this regard, 11 12 with one such product having successfully undergone phase I testing in people.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytokine concentrations in a trehalose‐stabilised lyophilised canine platelet product: a preliminary study

Goggs

Cremer²,

Brooks

2020

Veterinary Record Open

View full text Add to dashboard Cite

BackgroundPlatelet transfusion is indicated for haemorrhage due to severe thrombocytopenia and for trauma associated coagulopathy. Febrile non-haemolytic transfusion reactions are a common complication of platelet transfusions in people and may be due to accumulated inflammatory cytokines. The present study aimed to determine the cytokine profile of a novel canine lyophilised platelet product following reconstitution, to assess the lyophilised platelets’ activation response to physiological platelet agonists and to compare the cytokine profiles of basal and stimulated canine lyophilised platelets.MethodsCell counts and biochemical analyses were conducted following reconstitution. Cytokine concentrations were measured with a canine-specific multiplex immunocapture assay and with an electrochemiluminescent ELISA. Aliquots of reconstituted product from three separate vials were activated for 10 minutes under non-stirred conditions using adenosine diphosphate, thrombin or convulxin and their cytokine concentrations compared with unactivated samples. Flow cytometry and light-transmission aggregometry were used to evaluate the product’s ability to express a procoagulant surface, degranulate and aggregate. Fresh platelet-rich plasma was used as a positive control.ResultsThe product had a mean±SD particle count of 1.23±0.2×109/ml, contained platelets that expressed surface phosphatidylserine before agonist stimulation and was capable of aggregation in response to thrombin stimulation suggesting that the product may have haemostatic potential following in vivo administration. Cytokine concentrations measured by the immunocapture assay were generally low, while twofold to threefold increases relative to published intervals were noted for several cytokines using the ELISA. Concentrations of chemokine (C-X-C) motif ligand 8 and tumour necrosis factor-α were significantly increased as measured by the ELISA, but not by the immunocapture assay, while concentrations of KC-like were significantly increased as measured by the immunocapture assay. Stimulation with platelet agonists did not affect measured cytokine concentrations.ConclusionFurther study of the effects of administration of this lyophilised platelet product is warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of cytokine concentrations in a trehalose‐stabilised lyophilised canine platelet product: a preliminary study

Goggs

Cremer²,

Brooks

2020

Veterinary Record Open

View full text Add to dashboard Cite

show abstract

“…The treatment process should be adjusted and updated based on advances in new treatment techniques and concepts, changes in the fatality effects of the weapons of war, and changes in the PLA’s combat unit system. In addition, strong logistical support is a prerequisite for the implementation of the above treatment measures (e.g., transporting blood products during the battlefield emergency treatment stage [ 95 ]). It is expected that with the enhancement of the PLA’s military support capabilities, the existing treatment processes will be optimized accordingly.…”

Section: Prospectmentioning

confidence: 99%

Chinese expert consensus on echelons treatment of pelvic fractures in modern war

et al. 2018

View full text Add to dashboard Cite

The characteristics and treatment of pelvic fractures vary between general conditions and modern war. An expert consensus has been reached based on pelvic injury epidemiology and the concepts of battlefield treatment combined with the existing levels of military medical care in modern warfare. According to this consensus, first aid, emergency treatment and early treatment of pelvic fractures are introduced in three separate levels. In Level I facilities, simple triage and rapid treatment following the principles of advanced trauma life support are recommended to evaluate combat casualties during the first-aid stage. Re-evaluation, further immobilization and fixation, and hemostasis are recommended at Level II facilities. At Level III facilities, the main components of damage control surgery are recommended, including comprehensive hemostasis, a proper resuscitation strategy, the treatment of concurrent visceral and blood vessel damage, and battlefield intensive care. The grading standard for evidence evaluation and recommendation was used to reach this expert consensus.

show abstract

“…Following the PROMMTT study, 1:1 and 1:2 resuscitation strategies gained broader acceptance for the severely injured trauma patient. For example, the United States military adopted a 1:1:1 transfusion strategy until hemorrhage control is obtained (54). Nevertheless, lacking randomized data to support a one to one resuscitative strategy, some doubts remained.…”

Section: Emergency Departmentmentioning

confidence: 99%

Damage Control Resuscitation

Samuels¹,

Moore²,

Moore³

2017

chr

View full text Add to dashboard Cite

Damage control surgery is a combination of temporizing surgical interventions to arrest hemorrhage and control infectious source, with goal directed resuscitation to restore normal physiology. The convention of damage control surgery largely arose following the discovery of the lethal triad of hypothermia, acidosis, and coagulopathy, with the goal of Damage Control Surgery (DCS) is to avoid the initiation of this “bloody vicious cycle” or to reverse its progression. While hypothermia and acidosis are generally corrected with resuscitation, coagulopathy remains a challenging aspect of DCS, and is exacerbated by excessive crystalloid administration. This chapter focuses on resuscitative principles in the four settings of trauma care: the prehospital setting, emergency department, operating room, and intensive care unit including historical perspectives, resuscitative methods, controversies, and future directions. Each setting provides unique challenges with specific goals of care.

show abstract

The Armed Services Blood Program

Abstract: Epidemiologic study, level IV.

Cited by 21 publications

References 24 publications

Evaluation of cytokine concentrations in a trehalose‐stabilised lyophilised canine platelet product: a preliminary study

Evaluation of cytokine concentrations in a trehalose‐stabilised lyophilised canine platelet product: a preliminary study

Chinese expert consensus on echelons treatment of pelvic fractures in modern war

Damage Control Resuscitation

Contact Info

Product

Resources

About