The assembly of integrated continuous flow platform for on-demand rosiglitazone and pioglitazone synthesis

Abstract

The thiazolidinediones manufacturing in a batch process is often carried out at different locations, where each successive batch collects a certain amount of intermediate followed by its transportation to another...

Thermal/photochemical micro-flow probe system for direct C–H bond functionalization of biologically active molecules

“…After the successful completion of the two-step diazo-transfer and light-induced N-H insertion, we realized that most diazo compounds 4 synthesized via two individual steps require refrigeration storage and must be kept in dark conditions because of their self-dimerization reaction to generate impurities. 43,44 Thus, a safe and efficient integrated [45][46][47][48][49][50] chemical approach is needed to expand the scope of the diazo-transfer and lightinduced N-H insertion, including sulfonyl azide chemistry, towards new unexplored dimensions. The need of the hour is to realize a reactor platform consisting of microfluidic devices that could enable in situ generation of highly energetic diazo compounds with toxic sulfonyl azide reagents, 51,52 which would subsequently aid in the synthesis of the desired amine product, all in a safe and sequential manner.…”

Programmable Light-Induced Carbene Generation for On Demand Chemical Synthesis: Introducing DigiChemTree

“…35 Recently, reaction auto-optimization platform opens the new era for the academia and industry to optimize the multivariable reaction condition at a time for a reaction. 36,37 To resolve the above mentioned industrial favourable methodology issues, we thought to employ integration of continuous ow reactions [38][39][40] backed with arti cial intelligence (AI) technology. [41][42][43][44][45][46][47][48][49] Herein, we are reporting the DigiChemTree to auto-optimize the light-Induced carbene generation and further coupling with various nucleophile O-H, S-H, N-H, cycloaddition reaction of the alkene, alkyne, C ≡ N, and cross-coupling with ethyl diazoester.…”

Micro-total process system machine (μ-TPSM) for rapid synthesis of antiretroviral darunavir

“…Recently, our research group has reported an individual and integrated continuous multi-step reaction protocol for the on-demand synthesis of daclatasvir, 27 rosiglitazone, 28 pioglitazone, 28 sildenafil, 29 etc. In continuation of our efforts on flow synthesis, we postulated that a rational choice of reagent and solvent in conjunction with close control of reaction conditions such as pressure, temperature, stoichiometric ratio and reaction time, commenced by a continuous flow process, would allow us to take up the on-demand synthesis of DRV efficiently.…”