The Association between Adiponectin Gene Polymorphism and Waist Circumference Changes in Obese/Overweight Adults after Aerobic Exercise and Diet Treatment

Muriyati,; Arimbi,; Asnidar,; Safruddin, Safruddin; Arundhana, Andi Imam

doi:10.29169/1927-5951.2019.09.05.2

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Environmental pollution [22,23], infectious diseases [24] creation of new medications are becoming a challenge for modern society, which is reflected in the development of medicine in which sometimes unexpected ways are used for problem solutions [25,26] for microbial contamination [27,28].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis

Ivannik

Torianyk

Moiseienko

et al. 2021

J. Pharm. Nutr. Sci.

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Background: An important aspect in the treatment of patients with intestinal yersiniosis is the administration of effective antibiotic therapy. Performed research aimed to determine the spectrum and level of antimicrobial activity of 2H-pyrano[2,3- c]pyridine derivatives on the museum and clinical strains of gram-negative microorganisms Yersinia enterocolitica. Methodology: The object of the study was 28 synthetic derivatives of 2H-pyrano[2,3- c]pyridine. The compounds were studied according to their chemical structure. We used the method of serial dilutions in Muller-Hinton liquid nutrient medium with a museum’s and clinical strains of Y.enterocolitica. Results: Studies indicate the promise of further study of the properties of 2H- pyrono[2,3-c]pyridine to create an effective antimicrobial medicine. According to the results of studies on action of antimicrobial compounds synthesized on the basis of 2H-pyrano[2,3-с]pyridine derivatives, it was found that the MIC of compounds for all Y. enterocolitica strains was 100.0 μg/ml. The MBCC of most cultures of Yersinia (72.3 %) was 200.0 μg/ml. Compound 2{3} had a pronounced antiyersiniotic activity, the inhibitory effect of which was manifested at a concentration of 25.0 μg/ml. Retarding the growth of most Yersinia strains (95.3%) with a MIC of 50.0 μg/ml, the MIC of compounds ranged from 50.0 to 200.0 μg/ml. After statistical data processing, pyridine derivatives (compounds 2{3} and 3{5}) were identified, possessing an effective bacteriostatic and bactericidal effect on Y. enterocolitica strains. Conclusions: The results of the research showed a high antimicrobial activity of 2H- pyrano[2,3-c]pyridine derivatives. The highest activity against Y. enterocolitica was found for 2-N2-arylimino-5-hydroxy-methyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-N1- aricarboxamide derivatives.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis

Ivannik

Torianyk

Moiseienko

et al. 2021

J. Pharm. Nutr. Sci.

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Effect of Electronic Cigarettes on Oral Microbial Flora

Gargin¹,

Nessonova²,

Podrіgalo³

et al. 2021

J. Pharm. Nutr. Sci.

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Background: Despite well-documented adverse effects of tobacco consumption, cigarettes use is still rising and part of this increase is related to the popularization of alternative electronic nicotine delivery devices, such as electronic cigarettes (ECs). The aim of the performed research was to assess the effect of electronic cigarettes aerosol on the oral microbiota, using culture methods.Methodology: 30 ten-week-old WAG rats (female 76-81 g and male 86-94 g) were randomly distributed in two groups, as follows: Group 1 -control animals (n = 10); Group 2 -EC aerosol exposed (n = 20). EC aerosol exposures were carried out by using the Boyarchuck chamber. During the study, the rat oral microbiota were collected four times: at the beginning of the experiment, on the 30 th , 60th and 90 th days. Microorganisms were identified using standard microbiological techniques.Results: EC exposure to Group 2 rats resulted in a depletion of colonies commensal microbes and a greater incidence of atypical species such as Klebsiella pneumoniae, Acinetobacter lwoffii, Candida albicans compared to Group 1 on day 90. The test of independence between frequency distibution of opportunistic microbes and duration of EC exposure showed a significance for Klebsiella pneumoniae -χ2= 8.017, p=0.0456, Acinetobacter lwoffii -χ2= 36.772, p=0.0001, and Candida albicans -χ2=8.689, p=0.0337. Conclusions:The impact of electronic cigarettes facilitated colonization of the oral cavity by opportunistic bacteria and yeast.

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The Association between Adiponectin Gene Polymorphism and Waist Circumference Changes in Obese/Overweight Adults after Aerobic Exercise and Diet Treatment

Cited by 2 publications

References 15 publications

Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis

Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis

Effect of Electronic Cigarettes on Oral Microbial Flora

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