The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Abstract

Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081-2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.

Association betweenH. pyloriinfection and health Outcomes: an umbrella review of systematic reviews and meta-analyses

“…Overall, 3036 articles that met our search criteria were first identified from the seven databases. Sixty articles9–18 27–76 of observational studies were finally selected, covering 88 unique outcomes (figure 1). Fifty-four meta-analyses10–17 28–34 38–40 42–44 47–50 54–60 64–70 72–75 were reanalysed because they did not present all of the results of estimates (i.e.…”

“…No association with Increase risk of Decrease risk of Europe Cholangiocarcinoma, 14 colorectal, cancer, 75 diabetes mellitus, 39 diabetic nephropathy, 56 alcoholic cirrhosis, 33 Parkinson's disease 50 Barrett's oesophagus 32 Arrhythmia, 65 asthma, 16 biliary lithiasis, 73 migraine, 52 recurrent aphthous stomatitis, 40 chronic urticaria 34…”

“…Colorectal cancer, 75 biliary lithiasis, 73 chronic urticaria 34 Barrett's oesophagus, 32 asthma, 16 asthma 16 Arrhythmia, 65 diabetes mellitus, 39 alcoholic cirrhosis, 33 recurrent aphthous stomatitis 40 East (Asia, China)…”

“…Cholangiocarcinoma, 14 colorectal cancer, 75 colon neoplasia, 28 arrhythmia, 65 diabetes mellitus, 39 diabetic nephropathy, 56 biliary lithiasis, 73 ammonia levels in cirrhotic patients, 37 chronic cholecystitis and cholelithiasis, 27 Parkinson's disease, 50 open-angle glaucoma, 71 Henoch-Schonlein purpura, 64 migraine, 52 chronic urticaria 34 Oesophageal squamous cell carcinoma, 13 Barrett's oesophagus, 32 asthma 16 Myocardial infarction, 15 COPD, 57 biliary lithiasis, 73 peptic ulcer disease, 10 alcoholic cirrhosis, 33 recurrent aphthous stomatitis, 40 multiple sclerosis 66 West Colon neoplasia, 28 myocardial infarction, 15 COPD, 57 peptic ulcer disease, 10 open-angle glaucoma 71 Oesophageal adenocarcinoma, 13 asthma, 16 multiple sclerosis 66 Oesophageal squamous cell carcinoma, 13 ammonia levels in cirrhotic patients 37 Africa Arrhythmia 65 Barrett's oesophagus, 32 diabetes mellitus, 39 peptic ulcer disease 10 Australia Barrett's oesophagus 32…”

Gastrointestinal and liver diseases and atrial fibrillation: a review of the literature

“…91,92 However, a meta-analysis of six studies observed no association between H. pylori infection and AF, though they did report significant publication bias. 93…”