The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis

Ruff, Samine; Engebretsen, Kristiane A.; Zachariae, Claus; Johansen, Jeanne Duus; Silverberg, Jonathan I.; Egeberg, Alexander; Thyssen, Jacob P.

doi:10.1111/bjd.16147

Cited by 90 publications

(43 citation statements)

References 70 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…found that patients with atopic dermatitis had a 3-4-fold increased prevalence of HE compared with controls. 84 Accordingly, the pooled proportion of adults with HE and a history of atopic dermatitis found in this meta-analysis reached 34.4%, with significantly higher estimates for children and adolescents (79.9%).…”

Section: Duration Eruptions and Age At Onset Of Hand Eczemamentioning

confidence: 62%

Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta‐analysis

et al. 2021

View full text Add to dashboard Cite

Accurate assessments of the burden of hand eczema (HE) in the general population are important for public awareness and intervention. The aim of this systematic review and meta-analysis was to provide updated estimates of prevalence and incidence, alongside additional epidemiological endpoints on HE in the general population.PubMed, Embase and Web of Science were searched for studies reporting the prevalence and/or incidence of HE in the general population. Proportion meta-analyses were performed to calculate pooled estimates of prevalence, incidence, severity, and the proportion of individuals with HE and a history of atopic dermatitis. Sixty-six studies were included in the quantitative analysis encompassing 568 100 individuals. The pooled estimates for lifetime, 1-year, and point prevalence were 14.5% (95% confidence interval [CI]: 12.6-16.5), 9.1% (95% CI: 8.4-9.8) and 4.0% (95% CI: 2.6-5.7), respectively. The pooled incidence rate of HE was 7.3 cases/1000 person-years (95% CI: 5.4-9.5). The occurrence of HE was 1.5-2 times higher in females than males. More than one third suffered from moderate/severe disease and around one third had a history of atopic dermatitis. HE was a recurrent, long-lasting disease with an average age at onset of the early-to mid-twenties. In conclusion; HE is a highly prevalent disease in the general population and carries a significant risk of long-term or chronic disease.

show abstract

Section: Duration Eruptions and Age At Onset Of Hand Eczemamentioning

confidence: 62%

Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta‐analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…However, a population-based twin study demonstrated that the heritability of HE was not explained by AD (Lerbaek et al, 2007). A meta-analysis of 26 studies found that AD was significantly associated with an increased prevalence of HE using point prevalence (odds ratio Ruff et al, 2018).…”

Section: Pathogenesismentioning

confidence: 99%

Current and emerging therapies for hand eczema

Lee

Maarouf

Hendricks

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

Although hand eczema (HE) and chronic hand eczema (CHE) are common conditions with significant disease burden, they traditionally have had limited treatment options beyond topical and short‐term systemic corticosteroids. We reviewed published and preliminary evidence on the current and emerging topical and systemic therapeutic agents for HE and CHE. The etiologies of various HE subtypes are discussed, and remaining knowledge and practice gaps are highlighted to encourage further investigations. A comprehensive search of http://clinicaltrials.gov and PubMed was completed for clinical trials that utilized known and emerging treatment options for HE and CHE. Several agents that target IL‐4 and IL‐13 signaling, keratinocyte proliferation, inflammatory cytokine production, bacterial protein synthesis, and inflammatory mediator (TNF‐α, JAK1, JAK2, and JAK3) proliferation are shown to be involved in the pathogenesis of CHE. Systemic agents include dupilumab, alitretinoin, acitretin, cyclosporine, azathioprine, and probiotics. Topical agents include delgocitinib, retapamulin, halometasone/triclosan, calcipotriol/betamethasone, tacrolimus, and pimecrolimus. These modalities have demonstrated varying degrees of clinical efficacy, evaluated by subjective assessments and scoring indexes. Targeted therapies are emerging for HE, but options are still limited, partially due to our narrow understanding of this heterogeneous condition. Additional and targeted therapeutic options are needed to match the rising prevalence and burden of HE. Keypoints Hand eczema (HE) is a heterogenous dermatosis with limited therapeutic options due to a lack of international guidelines regarding classification of HE subtypes and treatment. This review discusses current and emerging topical and systemic agents and their efficacies in the treatment of different types of hand eczema.

show abstract

“…Endogene risikofaktorer omfatter forandringer i hudbarrieren som for eksempel atopisk eksem (7,8). Mutasjon i genet for filaggrin, et barriereprotein i huden, er en risikofaktor både for atopisk eksem og kronisk håndeksem (9).…”

Section: Klinisk Bilde Risikofaktorer Og Inndelingunclassified

Arbeidsrelatert håndeksem

Kvam¹,

Alfonso²,

Berents³

et al. 2019

Tidsskriftet

View full text Add to dashboard Cite

Regionalt senter for astma, allergi og overfølsomhet (RAAO) og Seksjon for miljø-og arbeidsmedisin Oslo universitetssykehus Hun har bidratt med idé, utforming/design, litteratursøk, utarbeiding/revisjon av manuset og godkjenning av innsendte manusversjon. Mari Sveen Kvam er spesialist i revmatologi og er i spesialisering i arbeidsmedisin. Hun er rådgivende overlege i NAV arbeid og ytelser. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.

show abstract

The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis

Cited by 90 publications

References 70 publications

Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta‐analysis

Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta‐analysis

Current and emerging therapies for hand eczema

Arbeidsrelatert håndeksem

Contact Info

Product

Resources

About