The association between atopic disorders and keloids: A case-control study

Abstract

Background:Keloids and atopic disorders share common inducing and maintaining inflammatory pathways that are characterized by T-helper cell 2 cytokines.Aims and Objectives:The objective of this study was to test for associations between keloids and atopic eczema, asthma and hay fever.Materials and Methods:This was a case-control study with 131 patients diagnosed with keloids at our dermatology outpatient clinic between 2000 and 2012. Controls were 258 partners of keloid or sarcoidosis patients. Patient who reported life time prevalences of atopic eczema, asthma and hay fever were assessed using a questionnaire based on The European Community Respiratory Health Survey (ECRHS) and The International Study of Asthma and Allergies in Children (ISAAC).Results:The prevalence of asthma was lower in keloid patients (19/131 vs. 20/258, P = 0.035), as was being diagnosed with asthma by a physician (18/131 vs. 19/258, P = 0.039) and using inhalators for asthma (13/131 vs. 7/258, P = 0.02). After adjusting for age and non-European descent the odds ratio for having a keloid was (adjusted OR = 4.44; 95% CI 1.59–12.40) in asthmatics using inhalators. There were no clear and consistent associations found for keloids with atopic eczema or with hay fever.Conclusion:In conclusion, our study shows that keloids may be strongly associated with atopic asthma. Atopic eczema and hay fever do not seem to be correlated with keloid. Further studies are warranted to assess the validity of atopic asthma as a risk factor for the development of keloid scars.

<p>Risk Factors and Treatment Types for Asthma Severity Among Adult Patients</p>

“…It is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role and this chronic inflammatory disorder may cause airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing. This study finding is comparable to the study conducted in Ethiopia in 2015, 15 Uganda in 2012, 6 and Denmark on the major symptom and sign seen among those diagnosed with asthma. Similarly, from total units in the study, 130 (30.8%) severe, 132 (31.28%) moderate, and 160 (37.91%) mild asthmatic, respectively.…”

“…5 In Africa problems, including those arising from the over-utilization of health services, lack of trained staff and diagnostic apparatus, and non-availability and unaffordability of inhaled medications have hindered efforts to improve the management of asthma. 6,7 Some of the African countries are shown to have high asthma prevalence, for example, South Africa (8.1%), Nigeria (7-18%), and Egypt (9.4%). 8 With respect to asthma prevalence in Ethiopia nationwide data addressing the adult population is lacking.…”

Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

“…Previous studies of the association between AD and keloids have obtained inconsistent results. In Hajdarbegovic et al , 7 for example, a case–control study of 131 patients with keloids and 258 controls recruited during 2000–2012 revealed no association between AD and keloids in the adjusted model (adjusted OR 1.27; 95% CI 0.76 to 2.13). However, the questionnaire-based reporting method used in that study may have caused information bias resulting in under-diagnosis of AD.…”

“…Underdiagnosis of keloids is also common because patients with keloids are often immigrants, who may be unaccustomed to seeking prompt medical attention for non-critical medical problems. Additionally, the diverse ancestry of the population analysed in Hajdarbegovic et al 7 may have had a confounding effect on the association between AD and keloids. A final limitation of Hajdarbegovic et al is its small sample size.…”

“… 1 Earlier studies have also shown that ADAM33 is associated with immune-mediated disorders such as atopic dermatitis (AD). 7 8 In the first epidemiological study of the relationship between ADAM33 gene polymorphisms and AD risk, Matsusue et al reported a significant association between ADAM33 gene polymorphisms and AD in comparisons of 140 children with AD and 258 healthy controls recruited from June 2006 to January 2007. We hypothesised that AD and keloids may develop through common pathways, particularly in the ADAM33-related gene.…”