The Association Between Benign Paroxysmal Positional Vertigo and Autoimmune Chronic Thyroiditis Is Not Related to Thyroid Status

Papi, Giampaolo; Guidetti, G; Corsello, Salvatore Maria; Donato, Carlo Di; Pontecorvi, Alfredo

doi:10.1089/thy.2009.0319

Cited by 30 publications

(39 citation statements)

References 4 publications

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“…Similarly, a higher prevalence of BBPV in euthyroid AITD patients than in healthy controls has been reported. These findings suggest an actual relationship between vestibular disorders and thyroid autoimmunity independently from thyroid function …”

Section: Introductionmentioning

confidence: 68%

“…Although several studies documented a high prevalence of HT in patients affected by MD and BPPV, scanty data still exist on the possible pathogenic role of HT – with or without dysfunction – in the development of endolymphatic hydrops . In this setting, Papi et al . reported a higher prevalence of BPPV in patients with euthyroid HT than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…In the last years, coexisting AITD has been described in a percentage of patients with vestibular disorders, as Ménière's disease (MD) or benign paroxysmal positional vertigo (BPPV) . In the former disease, an autoimmune origin has been postulated, and we recently showed a relationship between MD and thyroid autoimmunity regardless of thyroid function .…”

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity

Chiarella

Tognini

Nacci

et al. 2014

Clinical Endocrinology

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Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity

Chiarella

Tognini

Nacci

et al. 2014

Clinical Endocrinology

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show abstract

“…Aging, diabetes mellitus, hypertension, thyroiditis, hyperlipidemia, stroke, osteopenia, osteoporosis, and vitamin D deficiency are responsible for causing the degenerative changes of the neuroepithelial membrane [11][12][13][14][15] . In particular, over the last 15 years, several studies have investigated the role of vitamin D deficiency and osteoporosis [4,[15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cervical Vestibular-Evoked Myogenic Potential Findings in Benign Paroxysmal Positional Vertigo

Karataş

Yüce²,

Cebi³

et al. 2016

Int Adv Otol

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OBJECTIVE:Although there has been a wide consensus on the mechanism of nystagmus and clinical presentation of benign paroxysmal positional vertigo (BPPV), the neuroepithelial pathophysiology of BPPV still remains unclear. In this study, we aimed to clarify the pathophysiology of BPPV by evaluating the cervical vestibular-evoked myogenic potential (cVEMP) findings of patients. MATERIALS and METHODS:Thirty-six BPPV patients and 20 healthy volunteers were included. Bilateral cVEMP tests were performed on all participants. The participants were divided into the following three groups: those with a BPPV-affected ear, those with a BPPV-unaffected ear, and the healthy control group. RESULTS:There were no significant differences regarding the latencies of the first positive (p1) and negative (n1) peaks among the three groups. The mean normalized amplitude asymmetry ratio also did not differ between the BPPV and control groups. However, the normalized amplitudes of the BPPV patients (with both affected and unaffected ears) were significantly lower than those of the healthy control group. CONCLUSION:We detected that the cVEMP data of the affected and unaffected ears of the BPPV patients was similar and that their normalized amplitudes significantly differed from those of the healthy controls. Eventually, we concluded that even if the symptoms of BPPV were unilateral, the findings suggest that the bilateral involvement of the macular neuroepithelium is important in understanding the pathophysiology of BPPV. This finding supports the conclusion that the pathophysiological process starts with neuroepithelial membrane degeneration and continues with otoconia separation.

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“…In middle aged and older people, idiopathic BPPV cases are much more common. It is becoming increasingly evident that idiopathic BPPV cases can be associated with other illnesses such as migraine [9], [11]–[16], vestibular neuritis [17], [18], Meniere’s disease [9], [19]–[21], sudden hearing loss [19], [22]–[27], diabetes [28], [29], and autoimmune thyroiditis [31]. BPPV has also been linked with reduced bone mineral density [32]–[34], suggesting that the spontaneous release of otoconia may parallel bone demineralization (for review see [30]).…”

Section: Introductionmentioning

confidence: 99%

Gender-Based Comorbidity in Benign Paroxysmal Positional Vertigo

et al. 2014

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It has been noted that benign paroxysmal positional vertigo (BPPV) may be associated with certain disorders and medical procedures. However, most studies to date were done in Europe, and epidemiological data on the United States (US) population are scarce. Gender-based information is even rarer. Furthermore, it is difficult to assess the relative prevalence of each type of association based solely on literature data, because different comorbidities were reported by various groups from different countries using different patient populations and possibly different inclusion/exclusion criteria. In this study, we surveyed and analyzed a large adult BPPV population (n = 1,360 surveyed, 227 completed, most of which were recurrent BPPV cases) from Omaha, NE, US, and its vicinity, all diagnosed at Boys Town National Research Hospital (BTNRH) over the past decade using established and consistent diagnostic criteria. In addition, we performed a retrospective analysis of patients’ diagnostic records (n = 1,377, with 1,360 adults and 17 children). The following comorbidities were found to be significantly more prevalent in the BPPV population when compared to the age- and gender-matched general population: ear/hearing problems, head injury, thyroid problems, allergies, high cholesterol, headaches, and numbness/paralysis. There were gender differences in the comorbidities. In addition, familial predisposition was fairly common among the participants. Thus, the data confirm some previously reported comorbidities, identify new ones (hearing loss, thyroid problems, high cholesterol, and numbness/paralysis), and suggest possible predisposing and triggering factors and events for BPPV.

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The Association Between Benign Paroxysmal Positional Vertigo and Autoimmune Chronic Thyroiditis Is Not Related to Thyroid Status

Cited by 30 publications

References 4 publications

Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity

Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity

Evaluation of Cervical Vestibular-Evoked Myogenic Potential Findings in Benign Paroxysmal Positional Vertigo

Gender-Based Comorbidity in Benign Paroxysmal Positional Vertigo

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