The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli, Zhila; Shabani, Parisa; Gorgani‐Firuzjaee, Sattar; Hossein–Nezhad, Arash

doi:10.1186/s40200-016-0274-2

Cited by 15 publications

(19 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1] Moreover, only CTX and OC were proper bone markers in CAD patients with Type 2 DM, [19] however, no significant relation of OC to cardiovascular risk in our study. Study in Thai population was conducted to compare bone turnover between healthy people and CAD patients using biochemical markers of bone formation and resorption; and found that CAD patients have no higher risk for osteoporosis than healthy people.…”

Section: Discussioncontrasting

confidence: 57%

“…[16] Elevating of Thai aging population is a trend to increase with the number of osteoporosis in elderly [17] and will be fast increase along with common chronic diseases, such as diabetes mellitus and cardiovascular diseases. [18,19] From Thai nation-wide survey (during 2000-2001), the age-adjusted prevalence of osteoporosis in Thai women ranging in age from 40 to 80 years was 13.6% and 19.8% for femoral neck and lumbar spine, respectively. For men, the age-adjusted prevalence of osteoporosis was 12.6, 4.6, and 3.9% at the femoral neck, lumbar spine, and both sites, respectively.…”

Section: Original Articlementioning

confidence: 99%

See 1 more Smart Citation

Untitled

Sudjaroen¹

2018

AJP

View full text Add to dashboard Cite

Context: The association of bone turnover markers (BTMs) and cardiovascular disease had been representing. Aims: The study aimed to evaluate the association of osteoporosis status and prehypertension in elders, who were indicated by bone related -and cardiovascular risked -biochemical markers. Settings and Design: A cross-sectional study was carried out in Samut Songkhram, Thailand, and 105 elders were joined. , calcium, phosphorus, and magnesium); lipid profile (cholesterol, triglyceride, high density lipoprotein-cholesterol, and low density lipoprotein); and high sensitive C-reactive protein (hs-CRP) were analyzed using automatic analyzers. Blood pressure measurement was done after resting. Statistical Analysis Used: Descriptive data were represented as a mean ± standard deviation. One-way ANOVA was compared parameters within three elders groups. Pearson's correlation was tested for the relations of BMD with other parameters. Odds ratio was calculated for risk of prehypertension. Results: BMD was significantly correlated to calcium, phosphorus, and triglyceride in high, low, and very low levels, respectively. Inversely correlations of BMD with CTX and hs-CRP were significant in medium level. Risk of prehypertension was increased 1.12-fold with a decrement of T-score < −1.0. Increment of CTX, hs-CRP, and LDL-C was increased 1.93, 1.94, and 1.31-fold of prehypertension risks, respectively. Conclusions: Prehypertension was associated with osteoporosis, which indicated by inversely correlation of hs-CRP and CTX to BMD; and correlation of serum calcium, phosphorus, and triglyceride to BMD.

show abstract

Section: Discussioncontrasting

confidence: 57%

Section: Original Articlementioning

confidence: 99%

Untitled

Sudjaroen¹

2018

AJP

View full text Add to dashboard Cite

show abstract

“…At baseline, there was a significant association between a higher degree of LINE‐1 methylation and lower diastolic blood pressure, lower cholesterol/HDL ratio and lower eGFR. A previous study in T2DM individuals described higher DNA methylation levels in patients with albuminuria compared with those without albuminuria . In that study there was a significant increasing trend in global DNA methylation levels in relation to albuminuria categories (normal range of albuminuria/microalbuminuria/macroalbuminuria).…”

Section: So What Does It Mean?mentioning

confidence: 61%

“…A previous study in T2DM individuals described higher DNA methylation levels in patients with albuminuria compared with those without albuminuria. 7 In that study there was a significant increasing trend in global DNA methylation levels in relation to albuminuria categories (normal range of albuminuria/microalbuminuria/macroalbuminuria). It is noteworthy that the overall methylation level was quite high across the four CpG sites studied in the T2DM patients studied here.…”

Section: So What Doe S It Me An?mentioning

confidence: 80%

Assessment of global long interspersed nucleotide element‐1 ( LINE ‐1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2 DM ) individuals

Malipatil

Narayanan²,

Siddals

et al. 2018

Int J Clin Pract

View full text Add to dashboard Cite

Introduction Recent studies have indicated that methylation of the LINE‐1 elements is associated with an increased risk of worsening carbohydrate metabolism. It has been shown that overall DNA methylation of LINE‐1 elements could be considered as a risk factor for T2DM and its complications, independent of other established risk factors. Methods A total of 794 T2DM individuals from Salford, UK were included in this study (60% men n = 470). All patients had clinical and metabolic variables measured in 2002 (baseline outcomes) and annually through to 2016. Global LINE‐1 DNA methylation was measured at four CpG sites. The QIAGEN PyroMark Q96 MD pyrosequencer was used to quantify methylation. Results The overall mean ± SD global LINE‐1 methylation was 75.81 ± 3.25%. Cross‐sectional linear regression analysis at baseline year 2002 showed that LINE‐1 methylation was a significant predictor of diastolic BP (adjusted beta coefficient β = −0.25), estimated glomerular filtration rate (eGFR) (β = −0.48) and cholesterol HDL ratio (β = −0.04). A 10% increase in LINE‐1 methylation was associated with a lower diastolic BP by 2.5 mm Hg, a lower eGFR by 4.8 ml/min/1.73 m2 and decreased cholesterol/HDL ratio by 0.4 mmol/L. Longitudinal analysis over the 14‐year‐follow‐up periods showed that global LINE‐1 methylation at baseline was associated with lower BMI in women [β = −0.25] and lower cholesterol: HDL ratio [β = −0.07]. A 10% increase in LINE‐1 methylation was associated with reduction in BMI by 2.5 kg/m2 in women and reduction in cholesterol:HDL ratio by 0.7 mmol/L. Conclusion In a 14‐year longitudinal cohort of T2DM individuals, relations between global LINE‐1 DNA methylation status and specific metabolic markers were seen. Also, a higher degree of DNA methylation was predictive of less weight gain over time in women.

show abstract

“…[5] In Thailand, the increment of life period is a trend to increase the number of elders and the rate of osteoporosis will be rapidly increased [6] along with common chronic diseases, such as diabetic mellitus and cardiovascular diseases. [7][8][9]…”

Section: Introductionmentioning

confidence: 99%

Untitled

Sudjaroen¹

2018

AJP

View full text Add to dashboard Cite

Context: Calcaneal quantitative ultrasound (QUS) is attractive as a pre-screening tool for osteoporosis, alternative to dual-energy X-ray absorptiometry. Bone turnover markers (BTMs) are represented as bone formation indicators. QUS and BTM analysis may provide osteoporosis screening and bone turnover status, which provide benefit for osteoporosis management. Aims: The aims of this study were (1) to compare the values of bone mineral density (BMD) and BTMs, including N-terminal extension propeptide of type-I collagen, alkaline phosphatase (ALP), C-terminal telopeptide of type-I collagen (CTX), and osteocalcin (OC), and bonerelating biochemical parameters, such as 25-hydroxyvitamin D (25(OH)D), calcium, phosphorus and magnesium between osteoporotic, osteopenia, and normal BMD elders and (2) to investigate the relationship between serum BTMs and BMD. Materials and Methods: Determination of BMD, BTMs, and bone-related biochemical parameters from 150 of the elders at Amphawa District, Sumut Songkhram, was determined by calcaneal QUS and automatic analyzers, respectively. One-way ANOVA was used to compare continuous variables between three elder groups. Multiple comparisons among groups were used least-significance different. Pearson correlation was used to evaluate the correlation between BMD and BTMs. The statistical significance was considered at P < 0.05. Results and Discussion: BMD, calcium, phosphorus, and CTX levels were significantly different among three elder groups. CTX was significantly inversely correlated to BMD. Calcium, phosphorus, and CTX can be useful with osteoporosis screening by QUS, especially for osteopenia. Conclusions: Combination of calcaneal QUS and biochemical tests, including serum calcium, phosphorus, and CTX measurement as early diagnosis, provides more benefits for osteoporosis management and suitable for mass screening and intervention.

show abstract

The association between bone turnover markers and microvascular complications of type 2 diabetes

Cited by 15 publications

References 36 publications

Untitled

Untitled

Assessment of global long interspersed nucleotide element‐1 ( LINE ‐1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2 DM ) individuals

Untitled

Contact Info

Product

Resources

About