The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis

Yuan, Qing; Chen, Huifang; Zheng, Xianrui; Chen, Xiaming; Li, Qun; Zhang, Yanping; Zhang, Xiaorong; Shi, Ting-li; Zhou, Junhua; Chen, Qing; Song, Yu

doi:10.1007/s11033-014-3652-1

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…In contrast, no associa-tion was found between CD14 polymorphism and different forms of TB disease in white and Mestizos ethnic groups from Colombia (Pacheco et al, 2004). A metaanalysis by Yuan et al suggested that C-159T polymorphism in CD14 gene was associated with an increased risk of TB, especially in Asians, but not in Caucasians (Yuan et al, 2014). The explanation for these differences has not been found.…”

Section: Cd14 Moleculementioning

confidence: 97%

Immune response gene polymorphisms in tuberculosis

et al. 2015

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Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.

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Section: Cd14 Moleculementioning

confidence: 97%

Immune response gene polymorphisms in tuberculosis

et al. 2015

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“…Listed in the white portion of the Venn diagram are non-HLA genes with alleles that associate with Candida disease susceptibility 150,151,153,284–298 . Likewise, listed in the black portion are non-HLA genes with alleles that associate with Mycobacteria disease susceptibility 160–162,299–315 . Listed in the gray overlap are nine genes with alleles that associate with both Candida and Mycobacteria disease susceptibility: IRF8 154 , MBL2 156,316,317 , TLR2 157,314,318 , IL10 319–321 , IL12B 110,320 , IL12RB1 322–325 , RLTPR 326 , RORC 327 and STAT1 206,207,328–332 .…”

Section: Figurementioning

confidence: 99%

The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers

Robinson

Huppler

2017

Cytokine

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Mycobacteria and Candida species include significant human pathogens that can cause localized or disseminated infections. Although these organisms may appear to have little in common, several shared pathways of immune recognition and response are important for both control and infection-related pathology. In this article, we compare and contrast the innate and adaptive components of the immune system that pertain to these infections in humans and animal models. We also explore a relatively new concept in the mycobacterial field: biological commensalism. Similar to the well-established model of Candida infection, Mycobacterial species colonize their human hosts in equilibrium with the immune response. Perturbations in the immune response permit the progression to pathologic disease at the expense of the host. Understanding the immune factors required to maintain commensalism may aid with the development of diagnostic and treatment strategies for both categories of pathogens.

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“…As shown from our result, there is significant SNP diversity at the promoter region of CD14 gene, indicating selection sweep between the disease tolerant N'Dama and susceptible White Fulani cattle. Other reports have shown significant association of CD14 gene polymorphism with varying disease phenotypes, including monocyte surface expression in Canadian Holstein and Jersey cows during bovine mastitis [13], and in Chinese Holstein cows during bovine tuberculosis [15,38,46,47].…”

Section: Discussionmentioning

confidence: 96%

SNP Diversity in CD14 Gene Promoter Suggests Adaptation Footprints in Trypanosome Tolerant N’Dama (Bos taurus) but not in Susceptible White Fulani (Bos indicus) Cattle

Morenikeji

Capria

Ojurongbe

et al. 2020

Genes

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Immune response to infections has been shown to be mediated by genetic diversity in pattern recognition receptors, leading to disease tolerance or susceptibility. We elucidated naturally occurring variations within the bovine CD14 gene promoter in trypanosome-tolerant (N’Dama) and susceptible (White Fulani) cattle, with genomic and computational approaches. Blood samples were collected from White Fulani and N’Dama cattle, genomic DNA extracted and the entire promoter region of the CD14 gene amplified by PCR. We sequenced this region and performed in silico computation to identify SNP variants, transcription factor binding sites, as well as micro RNAs in the region. CD14 promoter sequences were compared with the reference bovine genome from the Ensembl database to identify various SNPs. Furthermore, we validated three selected N’Dama specific SNPs using custom Taqman SNP genotyping assay for genetic diversity. In all, we identified a total of 54 and 41 SNPs at the CD14 promoter for N’Dama and White Fulani respectively, including 13 unique SNPs present in N’Dama only. The significantly higher SNP density at the CD14 gene promoter region in N’Dama may be responsible for disease tolerance, possibly an evolutionary adaptation. Our genotype analysis of the three loci selected for validation show that mutant alleles (A/A, C/C, and A/A) were adaptation profiles within disease tolerant N’Dama. A similar observation was made for our haplotype analysis revealing that haplotypes H1 (ACA) and H2 (ACG) were significant combinations within the population. The SNP effect prediction revealed 101 and 89 new transcription factor binding sites in N’Dama and White Fulani, respectively. We conclude that disease tolerant N’Dama possessing higher SNP density at the CD14 gene promoter and the preponderance of mutant alleles potentially confirms the significance of this promoter in immune response, which is lacking in susceptible White Fulani. We, therefore, recommend further in vitro and in vivo study of this observation in infected animals, as the next step for understanding genetic diversity relating to varying disease phenotypes in both breeds.

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The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis

Cited by 8 publications

References 37 publications

Immune response gene polymorphisms in tuberculosis

Immune response gene polymorphisms in tuberculosis

The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers

SNP Diversity in CD14 Gene Promoter Suggests Adaptation Footprints in Trypanosome Tolerant N’Dama (Bos taurus) but not in Susceptible White Fulani (Bos indicus) Cattle

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