The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients

Koca, Nizameddin; Şensoy, Barış; Kırhan, Emine; Güllülü, Sümeyye; Ersoy, Canan; Dirican, Melahat; Sarandöl, Emre

doi:10.1007/s10157-019-01761-2

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum concentration is between 0.4 and 1.0 g/L. Fetuin-A is defined as a powerful inhibitor of hydroxyapatite formation in a saturated solution containing calcium, phosphate (38)(39)(40). VEGF-A exhibits significant activity with vascular and endothelial cells through its interactions with VEGFR1 and R2 receptors, which are prominent on the endothelial cell membrane.…”

Section: Discussionmentioning

confidence: 99%

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Yılmaz

Göçmen

Arikan

et al. 2020

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Skeletal system and some organs development changes in rat fetuses with 30 and 60 mg/kg caffeine and melatonin's (10 mg/kg) protective role against rat fetuses were investigated. Groups (n = 4) were formed as Control, LDC, HDC, LDC+melatonin, HDC+melatonin and melatonin. Fetuses were taken by cesarean section and stained using dual skeletal staining method and FESEM. TRAP and AP immune-reactivity concentrations were calculated. Oxidative stress and inflammatory markers were also measured by liver, bone and placenta samples. TNF-α, IL-1ß, IL-6, VEGF-A, SOST and Fetuin-A levels were measured in tissue by using ELISA. TBARS, SOD, GSH, GSSG, TOS, TAS, measured by spectrophotometric assay method. The mRNA levels of Agtr2 gene expressed in placental tissues of control rats and in placental tissues of rats exposed to HDC, LDC, MEL, HDC+MEL, LDC+MEL were analyzed by Real-time PCR. The gene expressions of Agtr2 were significantly upregulated in the placentas exposed to HDC, MEL, HDC+MEL and LDC+MEL (P<0,001). No significant difference in samples of the LDC group (P>0,05). According to these data, caffeine used during pregnancy delayed ossification; melatonin, a powerful antioxidant, was found to eliminate this effect. Besides, changes in angiotensin receptor expression observed in response to a caffeine and melatonin exposure result from high dose and join effect.

show abstract

Section: Discussionmentioning

confidence: 99%

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Yılmaz

Göçmen

Arikan

et al. 2020

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

“…The initial search revealed 14 studies that were potentially relevant. After a comprehensive full-text screening, nine studies were selected [ 2 , 3 , [6] , [7] , [8] , [9] , [10] , [11] , [12] ], including 3,280 patients with CAVD and 7,505 patients as controls. The Newcastle-Ottawa scale for bias assessment was utilized to determine the quality of the included studies.…”

Section: Methodsmentioning

confidence: 99%

Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis

Larik

2023

Atherosclerosis Plus

View full text Add to dashboard Cite

“…By contrast, lower fetuin-A levels are associated with both basal ganglia calcification (Fahr syndrome) [58] and higher vascular calcification scores in patients with end-stage disease [59]. However, no significant correlation was found between fetuin-A levels and both valvular calcification in kidney transplant recipients [60] or calcification in hemodialysis patients [61].…”

Section: Active Process: Synthesis Of Inhibitorsmentioning

confidence: 99%

Vascular Calcification: A Passive Process That Requires Active Inhibition

Villa-Bellosta

2024

Biology

View full text Add to dashboard Cite

The primary cause of worldwide mortality and morbidity stems from complications in the cardiovascular system resulting from accelerated atherosclerosis and arterial stiffening. Frequently, both pathologies are associated with the pathological calcification of cardiovascular structures, present in areas such as cardiac valves or blood vessels (vascular calcification). The accumulation of hydroxyapatite, the predominant form of calcium phosphate crystals, is a distinctive feature of vascular calcification. This phenomenon is commonly observed as a result of aging and is also linked to various diseases such as diabetes, chronic kidney disease, and several genetic disorders. A substantial body of evidence indicates that vascular calcification involves two primary processes: a passive process and an active process. The physicochemical process of hydroxyapatite formation and deposition (a passive process) is influenced significantly by hyperphosphatemia. However, the active synthesis of calcification inhibitors, including proteins and low-molecular-weight inhibitors such as pyrophosphate, is crucial. Excessive calcification occurs when there is a loss of function in enzymes and transporters responsible for extracellular pyrophosphate metabolism. Current in vivo treatments to prevent calcification involve addressing hyperphosphatemia with phosphate binders and implementing strategies to enhance the availability of pyrophosphate.

show abstract

The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients

Cited by 8 publications

References 41 publications

The protective role of melatonin against the effects of different doses of caffeine on the fetus

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis

Vascular Calcification: A Passive Process That Requires Active Inhibition

Contact Info

Product

Resources

About