The association between chronotype profile and temporomandibular disorders among college students

Dan, Ruichen; Li, Jiaheng; Zhao, Kangning; Yang, Zijiang; Dong, Yanhua; Fan, Peidi; Cheng, Qiaoyu; Wang, Jun; Xiong, Xin

doi:10.1111/odi.14859

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…They discovered that an evening chronotype is associated with the prevalence and severity of TMDs. Facial muscle pain and impaired lateral jaw movement scores were higher in evening and intermediate types, whereas morning type was a protective factor against TMDs [ 30 ]. These clinical studies indicate that circadian rhythm preference might impact the temporomandibular joint.…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway

Wei,

Wang,

et al. 2024

J Transl Med

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Background Temporomandibular joint osteoarthritis (TMJOA) has a high incidence rate, but its pathogenesis remains unclear. Circadian rhythm is an important oscillation in the human body and influences various biological activities. However, it is still unclear whether circadian rhythm affects the onset and development of TMJOA. Methods We disrupted the normal rhythm of rats and examined the expression of core clock genes in the mandibular condylar cartilage of the jaw and histological changes in condyles. After isolating rat mandibular condylar chondrocytes, we upregulated or downregulated the clock gene Per1, examined the expression of cartilage matrix-degrading enzymes, tested the activation of the GSK3β/β-CATENIN pathway and verified it using agonists and inhibitors. Finally, after downregulating the expression of Per1 in the mandibular condylar cartilage of rats with jet lag, we examined the expression of cartilage matrix-degrading enzymes and histological changes in condyles. Results Jet lag led to TMJOA-like lesions in the rat mandibular condyles, and the expression of the clock gene Per1 and cartilage matrix-degrading enzymes increased in the condylar cartilage of rats. When Per1 was downregulated or upregulated in mandibular condylar chondrocytes, the GSK3β/β-CATENIN pathway was inhibited or activated, and the expression of cartilage matrix-degrading enzymes decreased or increased, which can be rescued by activator and inhibitor of the GSK3β/β-CATENIN pathway. Moreover, after down-regulation of Per1 in mandibular condylar cartilage in vivo, significant alleviation of cartilage degradation, cartilage loss, subchondral bone loss induced by jet lag, and inhibition of the GSK3β/β-CATENIN signaling pathway were observed. Circadian rhythm disruption can lead to TMJOA. The clock gene Per1 can promote the occurrence of TMJOA by activating the GSK3β/β-CATENIN pathway and promoting the expression of cartilage matrix-degrading enzymes. The clock gene Per1 is a target for the prevention and treatment of TMJOA.

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Section: Discussionmentioning

confidence: 99%

Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway

Wei,

Wang,

et al. 2024

J Transl Med

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Exploring the causal effects of sleep characteristics on TMD-related pain: a two-sample Mendelian randomization study

Xu,

Ren,

Lin

et al. 2024

Clin Oral Invest

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Causal associations between sleep traits and temporomandibular disorders: a bidirectional mendelian randomization analysis

Xu,

Zhou

2024

Front. Genet.

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ObjectivesThis study aims to investigate the relationship between five sleep traits (insomnia, sleep duration, getting up in morning, snoring, and daytime nap) and temporomandibular disorders (TMD) using bi-directional Mendelian randomization.MethodsThe bi-directional Mendelian randomization study was conducted in two stages. Initially, sleep traits were examined as exposures while TMD was evaluated as an outcome, whereas the second step was reversed. The inverse variance weighted (IVW) method and other Mendelian randomization methods were used for analysis. Furthermore, we performed the MR-Egger intercept, MR-PRESSO, Cochran’s Q test, and “Leave-one-out” to assess the levels of pleiotropy and heterogeneity.ResultsThe IVW method indicates that getting up in the morning reduces the risk of developing TMD (OR = 0.50, 95% CI 0.30–0.81, p = 0.005), while insomnia may increase the risk of TMD (OR = 2.05, 95% CI 1.10–3.85, p = 0.025). However, other sleep traits are not associated with the risk of TMD, and having TMD does not alter an individual’s sleep traits. After removing outliers, the results remained robust, with no pleiotropy detected.ConclusionGenetically determined difficulty in getting up in the morning and insomnia can increase the risk of TMD. By optimizing sleep, the risk of developing TMD can be reduced. This underscores the importance of sleep in preventing TMD.

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The association between chronotype profile and temporomandibular disorders among college students

Cited by 3 publications

References 61 publications

Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway

Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway

Exploring the causal effects of sleep characteristics on TMD-related pain: a two-sample Mendelian randomization study

Causal associations between sleep traits and temporomandibular disorders: a bidirectional mendelian randomization analysis

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