The association between estimated average glucose levels and fasting plasma glucose levels

Abstract

OBJECTIVE:The level of hemoglobin A1c (HbA1c), also known as glycated hemoglobin, determines how well a patient's blood glucose level has been controlled over the previous 8–12 weeks. HbA1c levels help patients and doctors understand whether a particular diabetes treatment is working and whether adjustments need to be made to the treatment. Because the HbA1c level is a marker of blood glucose for the previous 60–90 days, average blood glucose levels can be estimated using HbA1c levels. Our aim in the present study was to investigate the relationship between estimated average glucose levels, as calculated by HbA1c levels, and fasting plasma glucose levels.METHODS:The fasting plasma glucose levels of 3891 diabetic patient samples (1497 male, 2394 female) were obtained from the laboratory information system at the Izmir Bozyaka Training and Research Hospital in Turkey. These samples were selected from patient samples that had hemoglobin levels between 12 and 16 g/dL. The estimated glucose levels were calculated using the following formula: 28.7 x HbA1c – 46.7. Glucose and HbA1c levels were determined using hexokinase and high performance liquid chromatography (HPLC) methods, respectively.RESULTS:A strong positive correlation between fasting plasma glucose levels and estimated average blood glucose levels (r = 0.757, p<0.05) was observed. The difference was statistically significant.CONCLUSION:Reporting the estimated average glucose level together with the HbA1c level is believed to assist patients and doctors determine the effectiveness of blood glucose control measures.

Distribution Patterns and Risk Factors of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Bogor, Indonesia

“…An examination of the biomedical parameters of the diabetes subjects in this study showed that there were no statistical differences in the glycemic characteristics of FPG, OGTT, and HbA1c between the male and female groups. In line with the results of this study, studies in Turkey, in patients at a high risk for diabetes in the US, and in cynomolgus monkeys with impaired FPG, indicate that sex is not associated with FPG level [12][13][14]. Another study on diabetic and nondiabetic subjects showed significant differences in FPG level between males and females [15].…”

Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta‐analysis of clinical trials

“…Our meta-analysis showed a significant reduction in HbA1c following N. sativa consumption. As HbA1c reflects average glucose in the past 90 days (Bozkaya, Ozgu, & Karaca, 2010), we performed additional subgroup analysis according to trial duration (<90 days and ≥90 days). Subgroup analysis revealed that HbA1c was significantly reduced in trials with <90 days length, whereas a borderline significant reduction was found in the studies with ≥90 days length.…”

Genetic determinants of glucose levels in pregnancy: genetic risk scores analysis and GWAS in the Norwegian STORK cohort

“…Validation of the physiological relevance of the PCs is important, but challenging, since few studies provide gold standard measurements of metabolic features in combination with FDA of OGTT. In non-pregnant populations, high correlations between HbA1c and FG and 2hG have been found (34,35). It may therefore be speculated that the information in average measurements like the HbA1c may partly overlap with the information in the PC1 scores.…”