The Association Between Extracellular Matrix Metalloproteinase Inducer Polymorphisms and Coronary Heart Disease: A Potential Way to Predict Disease

Weng, Yingzheng; Chen, Tingting; Ren, Jianfei; Lu, Difan; Liu, Xiaowei; Lin, Shengyou; Xu, Chao; Lou, Jiangjie; Chen, Xiaofeng; Tang, Lijiang

doi:10.1089/dna.2019.5015

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Furthermore, studies have identified causal SNPs within CD147, which have been associated with coronary heart disease and acute myeloid leukemia [51,53]. These include rs8637, rs8259, rs4919862, rs4919859, and rs6758, which have been previously identified for possible impact on COVID-19 severity [151].…”

Section: Nrp1mentioning

confidence: 99%

Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities

Adimulam

Arumugam

Gokul

et al. 2023

IJMS

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a global pandemic, with an alarming infectivity and mortality rate. Studies have examined genetic effects on SARS-CoV-2 disease susceptibility and severity within Eurasian populations. These studies identified contrasting effects on the severity of disease between African populations. Genetic factors can explain some of the diversity observed within SARS-CoV-2 disease susceptibility and severity. Single nucleotide polymorphisms (SNPs) within the SARS-CoV-2 receptor genes have demonstrated detrimental and protective effects across ethnic groups. For example, the TT genotype of rs2285666 (Angiotensin-converting enzyme 2 (ACE2)) is associated with the severity of SARS-CoV-2 disease, which is found at higher frequency within Asian individuals compared to African and European individuals. In this study, we examined four SARS-CoV-2 receptors, ACE2, Transmembrane serine protease 2 (TMPRSS2), Neuropilin-1 (NRP1), and Basigin (CD147). A total of 42 SNPs located within the four receptors were reviewed: ACE2 (12), TMPRSS2 (10), BSG (CD147) (5), and NRP1 (15). These SNPs may be determining factors for the decreased disease severity observed within African individuals. Furthermore, we highlight the absence of genetic studies within the African population and emphasize the importance of further research. This review provides a comprehensive summary of specific variants within the SARS-CoV-2 receptor genes, which can offer a better understanding of the pathology of the SARS-CoV-2 pandemic and identify novel potential therapeutic targets.

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Section: Nrp1mentioning

confidence: 99%

Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities

Adimulam

Arumugam

Gokul

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Moreover, a study by Yingzhen Weng et al explored the role of SNVs in CD147 and matrix metalloproteinase-9 (MMP-9) in the susceptibility and severity of coronary artery disease (CAD). They genotyped the rs8259T>A, rs28915400G>T, rs4919859G>C, rs6758G>A, and rs8637G>A CD147 variants and rs3918242C>T MMP-9 variant in 812 patients and 258 controls and found associations between rs8259T>A and rs3918242C>T variants and CAD, suggesting their involvement in the pathological process of the disease [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

CD147 rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population

et al. 2023

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Background: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical manifestations of COVID-19 range from mild flu-like symptoms to severe respiratory failure. Nowadays, extracellular matrix metalloproteinase inducer (EMMPRIN), also known as cluster of differentiation 147 (CD147) or BASIGIN, has been studied as enabling viral entry and replication within host cells. However, the impact of the CD147 rs8259T>A single nucleotide variant (SNV) on SARS-CoV-2 susceptibility remains poorly investigated. Objective: To investigate the impact of rs8259T>A on the CD147 gene in individuals from Mexico with COVID-19 disease. Methods: We genotyped the CD147 rs8359T>A SNV in 195 patients with COVID-19 and 185 healthy controls from Mexico. In addition, we also measured the expression levels of CD147 and TNF mRNA and miR-492 from whole blood of patients with COVID-19 through RT-q-PCR. Results: We observed a significant association between the CD147 rs8259T>A SNV and susceptibility to COVID-19: T vs. A; OR 1.36, 95% CI 1.02–1.81; p = 0.037; and TT vs. AA; OR 1.77, 95% CI 1.01–3.09; p = 0.046. On the other hand, we did not find differences in CD147, TNF or miR-492 expression levels when considering the genotypes of the CD147 rs8259T>A SNV. Conclusions: Our results suggest that the CD147 rs8259T>A variant is a risk factor for COVID-19.

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“…CD147 and MMP expression levels are often elevated in inflammatory processes and tumors, reflecting the progression and metastasis of the tumor process. CD147 has previously been shown to be involved in the development of CHD [ 34 ]. Recent studies have shown that patients with severe asthma and COPD have high levels of matrix metalloproteinase 9 (MMP-9) in sputum, and influenza A virus infection increases CD147 expression in lung cells in bronchial asthma patients [ 32 ].…”

Section: The Role Of Angiotensin Converting Enzyme (Ace2) and Cd147 R...mentioning

confidence: 99%

COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments

Gilyazova

Timasheva

Карунас

et al. 2023

Non-coding RNA Research

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The Association Between Extracellular Matrix Metalloproteinase Inducer Polymorphisms and Coronary Heart Disease: A Potential Way to Predict Disease

Cited by 8 publications

References 49 publications

Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities

Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities

CD147 rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population

COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments

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