The Association Between Factor XIII Val34Leu Polymorphism and Early Myocardial Infarction

Hancer, Veysel Sabri; Diz‐Küçükkaya, Reyhan; Bilge, Ahmet Kaya; Özben, Beste; Öncül, Aytaç; Ergen, Gürsel; Nalçacı, Meliha

doi:10.1253/circj.70.239

Cited by 36 publications

(33 citation statements)

References 21 publications

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“…23 It was recently shown in some studies that some gene polymorphism has a protective effect against MI, whereas some contributes to susceptibility for MI. 30,31 Some of the contradictory findings concerning AT1R polymorphism and the risk of MI and hypertension may be due has not been found as an independent risk factor for MI or hypertension in either sex. 33,34 Our results are consistent with these reports and we found no difference in the distribution of the A/C1166 genotype or allele frequency between the patients and the control group in either sex.…”

Section: 7±04 Ns No Significant Difference Was Found Among Three Gementioning

confidence: 99%

Association Between A/C1166 Gene Polymorphism of the Angiotensin II Type 1 Receptor and Biventricular Functions in Patients With Acute Myocardial Infarction

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et al. 2006

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cute myocardial infarction (AMI) is characterized by loss of contractile tissue and changes in ventricular geometry. 1 The presence of congestive heart failure or left ventricular (LV) systolic dysfunction is probably the most important risk factor in patients with AMI. 2 The development of right ventricular (RV) dysfunction has been reported following LV myocardial infarction (MI), 3,4 and is also associated with increased risk of shock, arrhythmia, and death. 5,6 After MI, the process of LV remodeling begins rapidly, usually within the first few hours after an infarct, and continues to progress. 7 Furthermore, it is known that the renin -angiotensin -aldosterone system (RAS) and angiotensin-converting enzyme (ACE) activity contribute to the remodeling process. 8 Angiotensin II (ATII) is the final effector of the RAS. It is a vasoactive peptide and leads to growth promotion, fibroblast proliferation, and the most potent vasoactive and salt-retaining effector peptide of the RAS, which is involved in blood pressure homeostasis and cardiovascular pathophysiology. Two subtypes of cell surface receptors, ATII type 1 receptor (AT1R) and ATII type 2 receptor Circulation Journal Vol. 70, October 2006 (AT2R), have been identified. Most of the actions of ATII are mediated by AT1, which is particularly prominent in the myocardium. 9,10 Although a number of polymorphisms of the AT1R gene have been identified, one of the most widely studied is an A-C substitution at position 1166 (A/C1166). 11 Two-dimensional (D) and Doppler echocardiography is a reliable tool for the diagnosis of systolic and diastolic dysfunction. The Doppler echocardiographic myocardial performance index (MPI) called the "Tei index", combining time intervals of LV contraction and relaxation, has been shown to be a powerful predictor of death and congestive heart failure after MI. 12,13 This index can be obtained easily, is reproducible and independent of the ventricular geometry, and has been shown to have potential for clinical application in the assessment of overall cardiac function in various disorders. 14 Poulsen et al recently reported that the LVMPI was a powerful predictor of death or congestive heart failure after MI, 15 and Moller et al showed that the RVMPI was increased in the acute phase of MI and was significantly correlated with indices of RV systolic dysfunction. 16 In a previous study, we reported higher LVMPI and RVMPI in patients with the DD genotype than in patients with the ID genotype of the ACE gene after anterior AMI. 17 Although there have been several association studies of the polymorphism of AT1R (A/C1166) in clinical endpoints, such as MI, 18 hypertension, 11 aortic stiffness, 19 and LV mass, 20 to our knowledge the relationship between AT1R polymorphism and biventricular function in anterior Methods and ResultsThe study group comprised 132 consecutive patients who were admitted to the coronary care unit with their first acute anterior MI. Systolic and diastolic diameters, volumes, inflow properties, ejection fraction an...

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Section: 7±04 Ns No Significant Difference Was Found Among Three Gementioning

confidence: 99%

Association Between A/C1166 Gene Polymorphism of the Angiotensin II Type 1 Receptor and Biventricular Functions in Patients With Acute Myocardial Infarction

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Öztürk

Yazıcı

et al. 2006

Circ J

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“…Hancer et al [72] confi rmed a previous report that a polymorphism of the A subunit of the factor XIII gene (FXIII), resulting in a Val34Leu amino acid substitution, is associated with a decreased risk of acute myocardial infarction. Moreover, Undas et al [73] reported that aspirin inhibits FXIII activation to a greater degree in Leu 34 carriers.…”

Section: Other Gene Associations With Antiplatelet Drug Responsementioning

confidence: 90%

Genetic determinants of responsiveness to antiplatelet therapy

Král¹,

Lawal²,

Becker

2008

Curr Cardio Risk Rep

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“…185 Kohler et al 186 were the first to find a protective effect of the Leu34 variant for AMI. Several authors confirmed these findings, [187][188][189] however not all. 190,191 Two meta-analyses both suggest that the FXIII-A Val34Leu polymorphism exerts a moderate, but statistically significant protective effect against CAD.…”

Section: Factor XIIImentioning

confidence: 91%