The association between gallstone disease (GSD) and hip fracture: a nationwide population-based study

Lin, Cheng-Jyh; Hsu, Chin‐Jung; Chen, Chih-Hsiu; Yip, Hei-Tung; Hung, Tun-Yu; Ko, Jih‐Yang; Kuo, Sheng‐Fong

doi:10.1080/00325481.2020.1866865

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Osteoporosis is a prevalent disease in the aging society, and the gravest complication associated with osteoporosis is hip fracture. Hip fractures account for one-fourth of geriatric fractures necessitating hospitalization with the mortality rate reaching 20% [ 6 , 7 , 8 , 9 , 10 ]. T2DM patients are prone to suffer from higher risk of hip fracture, death after fracture, and hip fracture-free mortality.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study

Mao

Yip

et al. 2022

Biomedicines

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Aspirin and clopidogrel are commonly prescribed alone or together among the type 2 diabetes mellitus (T2DM) patients, and both agents could affect bone metabolism. This study aimed at demonstrating the effects of the dosage and the duration of aspirin and/or clopidogrel alone or together on the occurrence of hip fracture among T2DM patients. We chose the patients newly diagnosed with T2DM and divided them into four subgroups which are under aspirin monotherapy (78,522 patients), clopidogrel monotherapy (12,752 patients), dual therapy (7209 patients), and patients not taking antiplatelet drugs (401,686 patients). We found that only higher dosage (>360 cumulative daily defined dose (cDDD)) and longer duration (≥3 years) of antiplatelet agents could be associated with lower fracture risk. Compared with the subjects taking <1-year dual agents, the risk of hip fracture was 0.38-fold for the patients taking ≥3-year dual agents. Lower dosage (28–179 cDDD) and shorter duration (1~2 years) could even be associated with higher fracture risk. Overall, the best regimen to fend off the hip fracture was the use of aspirin and clopidogrel for ≥3 years.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study

Mao

Yip

et al. 2022

Biomedicines

View full text Add to dashboard Cite

show abstract

Correspondence on “The association between gallstone disease (GSD) and Hip fracture: a nationwide population-based study”

Chou

Lee

Chang

et al. 2022

Postgraduate Medicine

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Causal association between cholecystectomy and fracture: A Mendelian randomization study

Zheng,

Xie

2024

Medicine

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Previous observational studies have reported that cholecystectomy is associated with an increased risk of fracture. However, the causality of this association remains unclear. This study aimed to explore the causal relationship between cholecystectomy and fracture using a Mendelian randomization (MR) approach. Our primary analytical method was the comprehensive two-sample MR analysis, with inverse variable weighting (IVW) serving as the main analysis technique. In addition, we use Bayesian weighted MR analysis to further confirm the results of IVW method. To enhance the robustness of our findings, we employed multiple analytical approaches including MR-Egger, weighted mode, simple mode, and weighted median. We further conducted sensitivity analyses to validate the stability and feasibility of our dataset. The results of IVW methods showed that there had no significant causal effect of cholecystectomy on fracture (forward P value: .82, .63, .96, .60, .19, .40, .58, .38, .37, .97, and .50 for fracture of wrist and hand, fracture of femur, fracture of foot, fracture of forearm, fracture of lower leg, fracture of lumbar spine and pelvis, fracture of neck, fracture of ribs, fracture of shoulder and upper arm, fracture of skull and facial bones, and fracture of spine), the results of Bayesian weighted MR showed similar results (P > .05). In the reverse, fracture of femur (P = .01) and fracture of shoulder and upper arm (P = .01) showed increased risks of cholecystectomy. The sensitivity analysis showed that none of our analyses were horizontally pleiotropic (P > .05 for MR-Egger’s intercept method). Our results do not support the causal effect of cholecystectomy on fracture, which was opposite to most previous observational studies.

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The association between gallstone disease (GSD) and hip fracture: a nationwide population-based study

Cited by 3 publications

References 10 publications

Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study

Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study

Correspondence on “The association between gallstone disease (GSD) and Hip fracture: a nationwide population-based study”

Causal association between cholecystectomy and fracture: A Mendelian randomization study

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