The association between genomic variations and histological grade in hepatocellular carcinoma

Lee, Jun; Li, Guangbing; Guo, Yuan; Fan, Ning; Zang, Yunjin

doi:10.21037/tcr.2020.03.32

Cited by 4 publications

(2 citation statements)

References 31 publications

(41 reference statements)

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“…Library construction, sequencing, and mutation calling were performed by OrigiMed Corporation as previous research [ 17 , 18 ]. Briefly, 620 pan-cancer genes were captured by targeting amplification.…”

Section: Methodsmentioning

confidence: 99%

Genomic Mutations of Primary and Metastatic Lung Adenocarcinoma in Chinese Patients

Chen

Yan

et al. 2020

Journal of Oncology

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Lung cancer is still the leading cause of cancer-related death worldwide. Of lung cancer, lung adenocarcinoma (LUAD) is the most common subtype. Most patients with LUAD would develop into metastasis, which limits the available treatment. Targeted therapy and immunotherapy provided options for those advanced patients. But they also broached up challenges to identify the appropriate patients. This study aims to reveal the landscapes of genomic mutations in primary and metastatic LUAD and their actionability. This study enrolled 636 patients with LUAD, of whom 85 and 551 were from patients with and without metastasis, respectively. Next-generation sequencing technology was used to retrieve their genomic information. Genomic mutations including short nucleotide variation, long variation, copy number variations, and fusions were called. The corresponding actionability was revealed. A comparison of genomic mutations and actionability between primary and metastatic LUAD was performed. In primary tumors, BRCA2 and FAT3 were significantly mutated in older patients; while in metastases, ALK and NOTCH2 were significantly mutated in younger patients. Primary tumors in male patients were significantly mutated in LRP1B and KRAS. Compared to primary tumors, metastases harbored less short nucleotide variations but more copy number variations and fusions. In metastases, chromosome 1 and chromosome 9 had less short nucleotide variations and more CNV than in primary tumors. Genomic variations of activated dendritic cells were more frequently mutated in metastases. EGFR genomic variations were negatively associated with PD-L1 and TMB. Patients with EGFR inhibitor treatment tend to have lower PD-L1 expression. The revealed discrepancy between primary and metastatic lung cancer could help guide the treatment strategies and the development of novel drugs.

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Section: Methodsmentioning

confidence: 99%

Genomic Mutations of Primary and Metastatic Lung Adenocarcinoma in Chinese Patients

Chen

Yan

et al. 2020

Journal of Oncology

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“…Sequencing was conducted in a CLIA/CAP-compliant Molecular Diagnostics Service laboratory of Origimed Co., Ltd. The detailed sequencing procedure was described as our previous work [ 6 , 7 ]. Briefly, tissue samples were collected for each patient.…”

Section: Methodsmentioning

confidence: 99%

Clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma

Guo

Zeng

et al. 2021

BMC Cancer

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Background The goal of this study is to disclose the clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma. Methods A total of 86 Chinese patients were enrolled in this study. A panel of 579 pan-cancer genes was sequenced for the qualified samples from these patients. Driver genes, actionability, and tumor mutational burden were inferred and compared to a cohort of Western patients. Results Totally, 36 and 12 driver genes were identified in the Chinese and Western cohorts, respectively. Of them, seven driver genes (IDH1, KRAS, TP53, BAP1, PBRM1, ARID1A, and NRAS) were shared by the two cohorts. Four driver genes (SPTA1, ARID2, TP53, and GATA1) were found significantly correlated with the tumor mutational burden. For both cohorts, half of the patients had actionable mutations. The two cohorts shared the most actionable genes but differed much in their frequency. Though KRAS mutations were at the first and second actionable rank respectively for the Chinese and Western populations, they were still at a relatively low level of actionable evidence. Conclusions The study on the clinical significance of genomic alterations directs the future development of precision medicine for intrahepatic cholangiocarcinoma treatment.

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Construction and validation of a nomogram for patients with multiple hepatocellular carcinoma: A SEER-based study

Shen¹,

Zhou²,

et al. 2023

European Journal of Surgical Oncology

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The association between genomic variations and histological grade in hepatocellular carcinoma

Cited by 4 publications

References 31 publications

Genomic Mutations of Primary and Metastatic Lung Adenocarcinoma in Chinese Patients

Genomic Mutations of Primary and Metastatic Lung Adenocarcinoma in Chinese Patients

Clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma

Construction and validation of a nomogram for patients with multiple hepatocellular carcinoma: A SEER-based study

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