The Association Between Hyperuricemia and Hematological Indicators in a Chinese Adult Population

Abstract

The aim of this study was to explore the relationship between hyperuricemia and hematological indicators.Five hundred twenty-two male and 255 female subjects (18–90 years old) were recruited in the study. The level of serum uric acid (SUA), total white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin, hematocrit, and platelet count was measured, computed, and analyzed. Pearson correlation coefficients, Student t-tests, multivariate linear regression models, and multivariate logistic regression models were performed to analyze the results.For men, WBC count (r = 0.13, P < 0.01), RBC count (r = 0.15, P < 0.001), and hemoglobin (r = 0.11, P < 0.05) were significantly correlated with SUA. For women, WBC count (r = 0.24, P < 0.001), RBC count (r = 0.31, P < 0.001), hemoglobin (r = 0.31, P < 0.001), and hematocrit (r = 0.29, P < 0.001) were significantly correlated with SUA. For men, WBC (P < 0.01) and RBC (P < 0.05) counts were significantly higher in patients with hyperuricemia than in normal subjects. For men, after adjustment for confounding factors, those in the fourth quartiles of WBC counts had 1.66-fold increased odds of hyperuricemia as compared with those in the reference group. For women, after adjustment, those in the second to fourth quartiles of WBC count, RBC count, hemoglobin, and hematocrit had increased the odds of hyperuricemia as compared with those in the reference groups.Our study showed significant relations between the level of SUA and WBC count, RBC count, hemoglobin, and hematocrit, which could be important biological markers of hyperuricemia.

Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study

“…In our study, we firstly reported that transferrin levels were associated with SUA concentrations and the risk of HU, which was involved in iron metabolism. In the present study, we found that Hb levels were significantly, positively associated with SUA concentrations and the risk of HU, in agreement with the findings from previous studies with small sample size [ 18 , 58 ].…”

“…Increasing evidence shows that body iron metabolism plays an important role in the development of HU [ 2 , 15 , 16 , 17 , 18 ]. Serum ferritin (SF) is the most widely used biomarker in clinical and epidemiological studies to evaluate body iron stores, despite being affected by inflammation status.…”

“…Hemoglobin (Hb) is the most commonly used hematological test to assess iron status, although some studies have demonstrated that Hb is not a good indicator of iron stores [ 24 ]. A previous study reported that Hb was significantly, positively correlated with the risk of HU [ 18 ]; however, it is still not clear whether this association between Hb and the risk of HU is independent of lifestyle factors and inflammation markers.…”

Platelet to Lymphocyte Ratio and Glucocorticoid Resistance in Newly Diagnosed Primary Immune Thrombocytopenia: A Retrospective Cohort Study

“…Covariates involved in this present work can be summarized as demographic data, general information, our prior work, previous literature, and clinical experiences [17][18][19][20]. Therefore, the following variables were used to construct the fully-adjusted model: sex, age, height, weight, smoking status, drink habits, Helicobacter pylori burden, comorbidities (type 2 diabetes, cardiovascular disease, hyperuricemia), mean platelet volume (MPV), bleeding symptoms (skin, mucosa, organ), first-line treatment strategy (oral prednisone, high-dose dexamethasone) and mean platelet distribution (MPD) at diagnosis.…”

The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia.

“…Leukocyte count could independently predict hypertension in Chinese adults 16 . Two studies shown that hyperuricemia correlated with leukocyte count 17,18 . Whether elevated leukocyte in patients with hyperuricemia correlated with hypertension?…”