The association between <i>COMT</i> Val158Met polymorphism and migraine risk: A meta-analysis

Liao, Yaojun; Jiang, Jingru; Jin, Sanqing

doi:10.1177/0333102416649758

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…We did not observe significant differences in the distribution of the Val158Met polymorphism between women with episodic or chronic migraine and healthy women, supporting the assumption that this polymorphism is not involved in a predisposition to suffer from migraine. Our results agree with a recent systematic review concluding that the Val158Met polymorphism was not associated with migraine risk (13). Additionally, Takigawa et al did not also observe differences in the presence of other haplotypes of the COMT gene, e.g., rs4633, rs6267, rs6270 between individuals with migraine and healthy people (14).…”

Section: Val158met Polymorphism and Migrainesupporting

confidence: 92%

“…There are several studies investigating the role of Val158Met polymorphisms in migraine; although the results are inconsistent. The most recent meta-analysis did not observe a significant association between the Val158Met polymorphism and migraine (13). Similarly, a recent study, not included in the abovementioned meta-analysis, did not also reveal differences in Val158Met polymorphism distribution between subjects with migraine and healthy controls (14).…”

Section: Introductionmentioning

confidence: 89%

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Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine

Fernández‐de‐las‐Peñas

Ambite-Quesada

Palacios‐Ceña

et al. 2018

Pain Medicine

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Objectives To analyze the association between the rs4680 catechol-O-methyltransferase Val158Met polymorphism and to determine the association of this polymorphism with clinical, psychological, and pain sensitivity variables in women with episodic or chronic migraine. Methods Fifty women with episodic migraine, 50 with chronic migraine, and 50 matched healthy women participated. After amplifying the Val158Met polymorphism by polymerase chain reaction, we assessed genotype frequencies and allele distributions. Participants were classified according to the Val158Met polymorphism genotype into Val/Val, Val/Met, or Met/Met. A headache diary was used for collecting migraine pain features. Disability was assessed with the Migraine Disability Assessment Scale, trait/state anxiety levels with the State-Trait Anxiety Inventory, and depression/anxiety with the Hospital Anxiety and Depression Scale. Pressure pain thresholds (PPTs) were bilaterally assessed over the temporalis, the upper trapezius, the second metacarpal, and the tibialis anterior. Results The distribution of the rs4680 Val158Met genotype was not significantly different between women with and without migraine (P = 0.157). No differences in migraine features were found to be dependent on the Val158Met genotype. Women with the Met/Met genotype showed higher migraine-related disability than those with the Val/Val or Val/Met genotype in both migraine groups (P < 0.01). Women with chronic, but not episodic, migraine with the Met/Met genotype exhibited higher depressive and anxiety levels and lower PPTs than those with the Val/Val or Val/Met genotype. Conclusions The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype.

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Section: Val158met Polymorphism and Migrainesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 89%

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine

Fernández‐de‐las‐Peñas

Ambite-Quesada

Palacios‐Ceña

et al. 2018

Pain Medicine

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“…41 Similarly, the rs4680 Val158Met polymorphism has not been either associated to the presence of migraine. 42 The current results are supported by Takigawa et al finding of no significant differences in the presence of other haplotypes of the COMT gene, e.g., rs4633, rs6267, rs6270, between individuals with migraine, TTH or healthy people, 17 supporting that the COMT rs4680 Val158Met polymorphism seems to be not associated to TTH. Nevertheless, since the rs4680 Val158Met polymorphism has been associated, in some studies, to conditions such as fibromyalgia syndrome 43 or temporomandibular pain, 44 it is possible that this genotype may be associated to particular pain conditions rather than to chronic pain syndromes in general.…”

Section: Discussionsupporting

confidence: 80%

Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache

Fernández‐de‐las‐Peñas

Ambite-Quesada

Palacios‐Ceña

et al. 2019

The Clinical Journal of Pain

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Objectives: The aims of this study were: (1) to investigate the association between the rs4680 Val158Met polymorphism in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH); and (2) to analyze the association between the rs4680 Val158Met polymorphism with clinical, psychological, or psychophysical variables. Methods: In total, 50 women with FETTH, 50 with CTTH, and 50 matched headache-free women participated. After amplifying Val158Met polymorphism by polymerase chain reaction, the genotype frequencies and allele distributions based on restriction fragment length polymorphism were assessed. Participants were classified according to the Val158Met polymorphism rs4680 genotype (Val/Val, Val/Met, or Met/Met). A headache diary collected clinical features. Disability (Headache Disability Inventory), sleep quality (Pittsburgh Sleep Quality Index), and depression/anxiety levels (Hospital Anxiety and Depression Scale) were also assessed. Pressure pain thresholds were assessed bilaterally over the temporalis, upper trapezius, second metacarpal, and tibialis anterior by a blinded assessor. Results: The distribution of rs4680 Val158Met genotype was not significantly different between women with/without headache (P=0.796). No differences in headache features, disability, anxiety, or sleep quality were observed depending on the rs4680 Val158Met genotype. Women with CTTH, but not FETTH, carrying the Met/Met genotype had lower widespread pressure pain thresholds and higher depressive symptoms than those with Val/Val or Val/Met genotype (P<0.05). Conclusions: The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype.

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“…In this pilot study, which was performed on a small number of patients, no difference was found between the MOH and EM groups, but several genes were identified to change their DNA methylation profile in the chronification in MOH as compared with the controls including COMT (catechol-O-methyltransferase), ZNF234 (zinc finger protein 234), and SOCS1 (suppressor of cytokine signaling 1), which are all involved in the pathogenesis of drug addiction and neuropsychiatric illness. Variability in the COMT gene was associated with migraine, but the two remaining genes did not relate to migraine [74,75]. No difference was found between the MOH and EM groups.…”

Section: Dna Methylation In Migrainementioning

confidence: 99%

Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

Fila

Chojnacki

et al. 2019

Nutrients

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Migraines are a common disease with limited treatment options and some dietary factors are recognized to trigger headaches. Although migraine pathogenesis is not completely known, aberrant DNA methylation has been reported to be associated with its occurrence. Folate, an essential micronutrient involved in one-carbon metabolism and DNA methylation, was shown to have beneficial effects on migraines. Moreover, the variability of the methylenetetrahydrofolate reductase gene, important in both folate metabolism and migraine pathogenesis, modulates the beneficial effects of folate for migraines. Therefore, migraine could be targeted by a folate-rich, DNA methylation-directed diet, but there are no data showing that beneficial effects of folate consumption result from its epigenetic action. Furthermore, contrary to epigenetic drugs, epigenetic diets contain many compounds, some yet unidentified, with poorly known or completely unknown potential to interfere with the epigenetic action of the main dietary components. The application of epigenetic diets for migraines and other diseases requires its personalization to the epigenetic profile of a patient, which is largely unknown. Results obtained so far do not warrant the recommendation of any epigenetic diet as effective in migraine prevention and therapy. Further studies including a folate-rich diet fortified with valproic acid, another modifier of epigenetic profile effective in migraine prophylaxis, may help to clarify this issue.

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The association between COMT Val158Met polymorphism and migraine risk: A meta-analysis

Cited by 10 publications

References 33 publications

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine

Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache

Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

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