The Association Between Ideal Cardiovascular Health and Health-Related Quality of Life in Adults: A Population-Based Cross-Sectional Study

Wu, Xinyuan; Liu, Xiaotian; Liao, Wei; Kang, Ning; Sang, Shengxiang; Abdulai, Tanko; Niu, Miaomiao; Zhai, Zhihan; Pan, Mingming; Wang, Chongjian; Li, Yuqian

doi:10.3389/ijph.2021.592043

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Body mass index (BMI, kg/m 2 ) was calculated as weight (kg) divided by the square of height (m). The details of the equipment for anthropometric and clinical examinations have been introduced elsewhere ( 21 , 22 ).…”

Section: Methodsmentioning

confidence: 99%

Is first pregnancy age associated with hypertension in the Chinese rural women population?

Liao

et al. 2023

Front. Public Health

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IntroductionThe purpose of this study was to investigate the relationship between first pregnancy age and hypertension later in the life of women from Chinese rural areas.MethodsIn total, 13,493 women were enrolled in the Henan Rural Cohort study. Logistic regression and linear regression were used to evaluate the association between first pregnancy age and hypertension and blood pressure indicators [including systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP)]. The restricted cubic spline was used to examine the dose–response relationship between the first pregnancy age and hypertension or blood pressure indicators.ResultsAfter adjusting for potential confounders, each 1-year increase in first pregnancy age was associated with a 0.221 mmHg increase in SBP values, a 0.153 mmHg increase in DBP values, and a 0.176 mmHg decrease in MAP values (all P < 0.05). The β of SBP, DBP, and MAP showed a trend of first increasing and then decreasing with increasing first pregnancy age and there was no statistical significance after first pregnancy age beyond 33 years on SBP, DBP, and MAP, respectively. A 1-year increment in first pregnancy age was associated with a 2.9% [OR (95% CI): 1.029 (1.010, 1.048)] higher odds of prevalent hypertension. The odds of hypertension increased sharply and then eventually leveled off with an increment of first pregnancy age after adjusting for potential confounders.ConclusionFirst pregnancy age might increase the risk of hypertension later in life and might be an independent risk factor for hypertension in women.

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Section: Methodsmentioning

confidence: 99%

Is first pregnancy age associated with hypertension in the Chinese rural women population?

Liao

et al. 2023

Front. Public Health

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Associations between healthy lifestyle score and health-related quality of life among Chinese rural adults: variations in age, sex, education level, and income

et al. 2022

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Cardiovascular health and four epigenetic clocks

Lin

2022

Clin Epigenet

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Background Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is associated with a slower aging rate. The aging rate is measured by levels of epigenetic age acceleration (EAA), usually obtained from the residuals of regressing DNA methylation (DNAm) age on chronological age. However, little has been known about the association of CVH with biological aging in Asian populations. Methods and results We here analyzed blood DNAm data and clinical/lifestyle factors of 2474 Taiwan Biobank (TWB) participants, to investigate the association of CVH with EAA. CVH was assessed by seven components: smoking status, physical activity, dietary habits, body mass index, total cholesterol, fasting glucose, and blood pressure levels. Four measures of EAA were applied, among which two were based on the first-generation DNAm clocks (HannumEAA and IEAA) and two were based on the second-generation clocks (PhenoEAA and GrimEAA). After excluding 276 individuals with cardiovascular diseases, we regressed EAA on the CVH score (ranging from 0 to 7, integrating the abovementioned seven components) while adjusting for sex, drinking status, and educational attainment. Our results showed that a decrease in one point in the CVH score was associated with a 0.350-year PhenoEAA (p = 4.5E−4) and a 0.499-year GrimEAA (p = 4.2E−15). By contrast, HannumEAA and IEAA were not significantly associated with the CVH score. We have obtained consistent results within each generation of epigenetic clocks. Conclusions This is one of the first studies to comprehensively investigate the associations of CVH with four epigenetic clocks. Our TWB data showed that ideal CVH is associated with lower levels of EAA calculated according to the second-generation epigenetic clocks (PhenoEAA and GrimEAA). Having an ideal CVH status can lower EAA and reduce the risk of aging-related disorders.

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The Association Between Ideal Cardiovascular Health and Health-Related Quality of Life in Adults: A Population-Based Cross-Sectional Study

Cited by 4 publications

References 30 publications

Is first pregnancy age associated with hypertension in the Chinese rural women population?

Is first pregnancy age associated with hypertension in the Chinese rural women population?

Associations between healthy lifestyle score and health-related quality of life among Chinese rural adults: variations in age, sex, education level, and income

Cardiovascular health and four epigenetic clocks

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