The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study

Liang, Minghao; Ren, Xiuhong; Di, Huang; Ruan, Zhishen; Chen, Xianhai; Qiu, Zhanjun

doi:10.1080/0886022x.2023.2212080

Cited by 20 publications

(6 citation statements)

References 30 publications

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“…Deng YH et al demonstrated a positive nonlinear relationship between LAR and mortality in critically ill patients with sepsis [ 25 ]. A similar trend of LAR on mortality was demonstrated in the AKI subgroup in patients with sepsis [ 50 ]. To date, the predictive value of LAR for SAKI remains unclear.…”

Section: Discussionsupporting

confidence: 71%

The elevated lactate dehydrogenase to albumin ratio is a risk factor for developing sepsis-associated acute kidney injury: a single-center retrospective study

Fang,

Zhang,

Zhang

2024

BMC Nephrol

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Background There is no evidence to determine the association between the lactate dehydrogenase to albumin ratio (LAR) and the development of sepsis-associated acute kidney injury (SAKI). We aimed to investigate the predictive impact of LAR for SAKI in patients with sepsis. Methods A total of 4,087 patients with sepsis from the Medical Information Mart for Intensive Care IV (MIMIC IV) database were included. Logistic regression analysis was used to identify the association between LAR and the risk of developing SAKI, and the relationship was visualized using restricted cubic spline (RCS). The clinical predictive value of LAR was evaluated by ROC curve analysis. Subgroup analysis was used to search for interactive factors. Results The LAR level was markedly increased in the SAKI group (p < 0.001). There was a positive linear association between LAR and the risk of developing SAKI (p for nonlinearity = 0.867). Logistic regression analysis showed an independent predictive value of LAR for developing SAKI. The LAR had moderate clinical value, with an AUC of 0.644. Chronic kidney disease (CKD) was identified as an independent interactive factor. The predictive value of LAR for the development of SAKI disappeared in those with a history of CKD but remained in those without CKD. Conclusions Elevated LAR 12 h before and after the diagnosis of sepsis is an independent risk factor for the development of SAKI in patients with sepsis. Chronic comorbidities, especially the history of CKD, should be taken into account when using LAR to predict the development of AKI in patients with sepsis.

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Section: Discussionsupporting

confidence: 71%

The elevated lactate dehydrogenase to albumin ratio is a risk factor for developing sepsis-associated acute kidney injury: a single-center retrospective study

Fang,

Zhang,

Zhang

2024

BMC Nephrol

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“…These findings suggest that fermented feed positively regulates lipid metabolism, with fermentation breaking down crude fat into smaller molecules for better absorption. Total protein (TP) in serum reflects an animal's protein metabolic capacity, while albumin (ALB), synthesized by liver parenchymal cells, maintains plasma osmotic pressure [28,29]. This study found no significant differences in TP and ALB levels across the three groups, all within acceptable ranges.…”

Section: Discussionmentioning

confidence: 86%

Effects of Tail Vegetable Fermented Feed on the Growth and Rumen Microbiota of Lambs

Zhou,

Wang,

et al. 2024

Animals

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This study explored the impact of integrating fermented feed into the starter diet of lambs, focusing on growth, health, serum antioxidants, immune markers, rumen fermentation, and microbial communities. Thirty-six ten-day-old female Tail Han lambs were randomly divided into three experimental groups, which were separately fed with alfalfa hay (LA group), tail vegetable fermented feed (LB group), and tail vegetable fermented feed supplemented with 0.1% microbial inoculants (LC group) during the experimental period. This study assessed the influence of fermented feed on various parameters, including growth performance, fiber degradation, rumen fermentation, enzymatic activities, and ruminal histomorphology. The results indicate that compared to the control group, the addition of fermented feed can increase the daily weight gain of lambs. Simultaneously, the addition of fermented feed can enhance the total antioxidant capacity of serum (p < 0.05). The addition of fermented feed promoted the increased height of villi in the duodenum or jejunum of lambs (p < 0.05), and the ratio of villi height to crypt depth in the LB and LC groups was also improved (p < 0.05). The addition of fermented feed increased the richness and diversity of the rumen microbial community in lambs (p < 0.05), primarily increasing the relative abundance of Ruminococcus_1, Ruminococcaceae_UCG-005, Lachnospiraceae, and Lachnospiraceae_NK4A136_group.

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“… 5 , 6 Several studies have shown that albumin (ALB) concentrations are decreased during sepsis. 7 , 8 In addition, ALB is closely related to inflammation, and hypoalbuminemia is frequently observed in patients with inflammatory diseases. 9 , 10 Qian and Liu 11 also found that the rate of hypoalbuminemia was common among children with sepsis and serum albumin concentrations were negatively correlated with the prognosis, but its use among neonates has not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Albumin and C-reactive protein as diagnostic markers for neonatal sepsis: a retrospective study

Yin,

Fang,

Fan

et al. 2024

J Int Med Res

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Objective To assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis. Methods This retrospective study included all neonates who were admitted to the neonatal intensive care unit from January 2020 to June 2023. We studied 160 full-term neonates, including 80 with sepsis and 80 healthy controls. A multivariate analysis was conducted to evaluate the associations between ALB, CRP, and sepsis. Results CRP concentrations were significantly higher in neonates with sepsis than in controls (26.5 ± 8.6 vs. 3.6 ± 1.2 ng/L). At a cut-off point of 10.8 ng/L, CRP showed a sensitivity of 74.3% and a specificity of 80%. Moreover, ALB concentrations were significantly lower in neonates with sepsis than in controls (25.4 ± 2.5 g/L vs. 29.2 ± 2.6 g/L). At a cut-off point of 26.8, ALB showed a sensitivity of 75.6% and a specificity of 84.2%. Conclusions Our findings suggest that ALB and CRP concentrations on the first day of admission are different between neonates who do and those who do not develop sepsis. Higher CRP concentrations and lower ALB concentrations may indicate an increased risk of sepsis.

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The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study

Cited by 20 publications

References 30 publications

The elevated lactate dehydrogenase to albumin ratio is a risk factor for developing sepsis-associated acute kidney injury: a single-center retrospective study

The elevated lactate dehydrogenase to albumin ratio is a risk factor for developing sepsis-associated acute kidney injury: a single-center retrospective study

Effects of Tail Vegetable Fermented Feed on the Growth and Rumen Microbiota of Lambs

Albumin and C-reactive protein as diagnostic markers for neonatal sepsis: a retrospective study

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