The Association Between Maternal Age and the Prevalence of Congenital Heart Disease in Newborns from 2016 to 2018 in Single Cardiac Center in Jeddah, Saudi Arabia

Hashim, Sara T; Alamri, Raham A; Bakraa, Roaa; Rawas, Ranad; Farahat, Fayssal; Waggass, Rahaf

doi:10.7759/cureus.7463

Cited by 11 publications

(13 citation statements)

References 10 publications

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“…Further, the study indicated that ASD is the most frequent type of CHD among our participants followed by VSD. Similar findings were also reported from several regional and global studies [9][10][11][12][13]. In contrast, in one local study, VSD was the most evalent diagnosis among cases with CHD [14].…”

Section: Fig 5 the Outcome Of Patients With Chd (Cyanotic And A Cyasupporting

confidence: 88%

Pattern of Congenital Heart Disease among Libyan Children: A Single Centre Study

Mahmmed

Alhagamhmad

Goobae

et al. 2020

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Objective: To evaluate the pattern of Congenital heart disease (CHD) in Al-Mugref Teaching Hospital in the North Eastern part of Libya. Patients and Methods: This is a prospective descriptive study involved pediatric patients aged from day 1 until age of 15 years who were referred to the Cardiology department at Almugref Teaching Hospital for suspected CHD. Data were collected over a period of one year and all the recruited patients were subjected to a full cardiovascular system (CVS) examination and 2D Echocardiography (ECHO). Results and Conclusions: Out of the 719 total referred cases, 332 (46.1%) were confirmed having underlying CHD with predominant a cyanotic type 307 (92.5%). In terms of gender predominance, male to female ratio was 1.1: 1(176 vs. 156). Frequency of CHD in order frequency was as follow: Atrial septal defect (ASD) 134; 40.4%, Ventricular septal defect ( VSD) 102; 30.8%, Patent ductus arteriosus (PDA) 31; 9.3%, Pulmonary stenosis (PS)15; 4.5%, Atrioventricular (AV) canal defects 12; 3.6%, Aortic stenosis (AS)11; 3.3%, Tetraology of fallot (TOF) 9; 2.7%, Transposition of great arteries (TGA) 4; 1.2%, complex CHD (4; 1.2%), Rhabdomyoma (3;0.9%), total anomalous pulmonary venous drainage ( 3; 0.9%), Truncus arteriosus (TA) 2; 0.6%, Pulmonary atresia (PA)1; 0.3%, Co-arctation of aorta (COA) 1; 0.3%. In terms of the outcome, majority of the patients in a cyanotic group were advised for scheduled follow-ups (240; 78.18%), and almost a quarter had their heart defects being closed spontaneously in the initial visits (53; 17.26%). Further, eleven patients have undergone a surgical closure (3.58%) and three patients died early (0.9%). In contrast, almost a third of the cyanotic group died shortly after the diagnosis was made (8; 32%), and seven patients were successfully operated (28%); whereas ten cases offered a close monitoring with frequent follow ups (40%).

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Section: Fig 5 the Outcome Of Patients With Chd (Cyanotic And A Cyasupporting

confidence: 88%

Pattern of Congenital Heart Disease among Libyan Children: A Single Centre Study

Mahmmed

Alhagamhmad

Goobae

et al. 2020

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“…Interestingly, even though previous studies did not report an association between total CHD and maternal age, some did report an association of maternal age and specific CHD subtypes (Hashim et al, 2020; Miller et al, 2011). Specifically, based on our subgroup analysis, we found a positive association of ASD, PVS, CoA, ToF phenotypes with advanced maternal age.…”

Section: Discussionmentioning

confidence: 92%

Maternal age and the prevalence of congenital heart defects in Europe, 1995–2015: A register‐based study

Mamasoula

Bigirumurame

Chadwick

et al. 2023

Birth Defects Research

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Background: Evidence on the direction and strength of association between maternal age and the prevalence of congenital heart defects (CHD) in different age group categories is conflicting. Some studies have illustrated different trends with an increase in prevalence in younger and older age groups while other studies have reported a linear relationship. Given the increase in maternal age over recent years, it is important to study the CHD prevalence by maternal age.Objectives: To examine the association between maternal age and the prevalence of CHD in Europe between 1995 and 2015 using population-based data from 24 registries belonging to the European Surveillance of Congenital Anomalies (EUROCAT) network. Methods: Associations over time of all nonsyndromic CHD according to maternal age category and for three CHD severity groupings (severity group I: very severe; severity group II: severe; severity group III: less severe) were examined using Bayesian multilevel Poisson regression modeling. Further subgroup analyses were undertaken within four maternal age-bands: ≤24, 25-29, 30-34 and 35-44 years. Descriptive summaries are also presented.Results: There were 51,608 nonsyndromic CHD cases in Europe over the 20-year study period. Total prevalence for all CHD combined was increased for younger mothers (≤24 years) and for mothers 35-44 years of age when compared with mothers aged 25-29 years (reference group) (IRR: 1.05, 95% CI: 1.02, 1.07). The total prevalence was increased for severity group I (very severe) only for younger mothers compared to those aged 25-29 years (IRR: 1.14, 95% CI: 1.04, 1.23). We found an increased prevalence of the following CHD sub-

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“…Opposite to this observation, our population was free of chromosomal anomalies and shown to have this significant relation between the maternal age and TGA. Locally, Hashem et al 41 reported an insignificant association between the overall CHD risk and mean maternal age, but when they did a sub-analysis for the sample, VSD and PDA were associated with maternal age >35 years, while the other lesions did not reach that significance. Their lack of significance was attributed to the low statistical power of their sample size.…”

Section: Discussionmentioning

confidence: 92%

Risk factors for transposition of the great arteries in Saudi population

Alfarhan

Alquayt

Alshalhoub

et al. 2020

SMJ

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5¹«dAÃ« q¹b³ð-uDð vKŽ U¼dOŁQðË WKL²;« dD)« qÄ«uŽ rOOI²Ã ∫•«b¼_‫ا‬ AE©TGA® …dO³JÃ«-s¹cÃ« v{d*« lOL' wFł-dŁQÐ ôUŠ WÝ«-oe X¹dł√ ∫WO−NM*« e¹eFÃ« b³Ž pK*« WM¹bÄ w Â2016 Ë Â1999 wÄUŽ 5Ð TGA ? Ð rNBO Að fM'«Ë dLFÃ« jÐ«u{ b¹b%-AEW¹oeuF Ã« WOÐdFÃ« WJKL*« ¨ ÷U¹dÃ« ¨WO³DÃ« qL(« ÍdJÝË »-UÁ_« Ã«Ë" pÃ-w U0 ¨dD)« qÄ«uŽ XFLł AEWIÐUD²*«-AE UNÄ_« R UJðË s¹bÃ«uÃ« dLŽË WOIK)« VKIÃ« ÷«dÄ_ wKzUFÃ« a¹-U²Ã«Ë AETGA d¹uDð vKŽ dD)« qÄ«uŽ-UŁ¬ qOK×²Ã-«b×½ô« Ã-u/ Â«b ²Ý« w Èd³JÃ« 5¹«dAÃ« q¹b³ð lÄ v{dÄ 206 tŽuL−Ä UMK−Ý ∫ZzU²MÃ« WDO Ð TGA vÃ≈ …dO³JÃ« 5¹«dAÃ« q¹b³ð ôUŠ rO Ið-AEWÝ«-bÃ«-¨WÝË-b*« ôU(« w AE446 …-U² *« WO×BÃ« jÐ«uCÃ« X½UÂ AE…bIFÄË w qL(« ÍdJÝ hO Að-Ë ¨ ôU(« sÄ ©46%® 95 w WÐ«dÁ vKŽ-u¦FÃ« sÄ bÂRÄ wKzUŽ a¹-Uð UN¹bÃ ©17%® 35Ë ¨ UNÄ_« sÄ ©17.5%® 36 ¨jÐ«uCÃUÐ ôU×KÃ dD)« qÄ«uŽ W½-UIÄ X9 UÄbMŽ AE WOIK)« VKIÃ« ÷«dÄ√ sÄ dO³Â qJAÐ b¹eð R UJ²Ã«Ë ¨Â_« dLŽË ¨qL(« ÍdJÝË ¨WÐ«dIÃ« Ê√ błË AETGA ÀËbŠ U0 …dO³JÃ« 5¹«dAÃ« q¹b³ð-uD²Ã …dO³Â dDš qÄ«uŽ UM²Ý«-oe dNþ« ∫W ö)« wKzUFÃ« a¹-U²Ã«Ë ¨qL(« ÍdJÝË ¨vÃË_« Wł-bÃ« sÄ »-UÁ_« Ã«Ë" pÃ-w sÄ qÄ«uFÃ« Ác¼ oe«" AER UJ²Ã«Ë Â_« dLŽ …oeU¹"Ë ¨WOIK)« WO³KIÃ« U¼uA²KÃ AEqÁ_« vKŽ 5HF{-«bI0 dD)« Objectives: To assess potential risk factors and their effect on the development of transposition of the great arteries (TGA). Methods: A retrospective case-control study of all patients diagnosed with TGA between 1999 to 2016 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Age and gender-matched controls were selected. Risk factors, including consanguinity, gestational diabetes, family history of congenital heart disease, parental age, and maternal parity, were collected. Regression modeling was used to analyze the effects of risk factors on the development of TGA. Results: A total of 206 patients with transposition of the great arteries were enrolled in the study. Transposition of the great arteries cases were divided into simple and complex TGA. Selected healthy Original Article controls were 446. In the studied cases, consanguinity was found in 95 (46%) of cases, gestational diabetes was diagnosed in 36 (17.5%) mothers, and 35 (17%) had a confirmed family history of congenital heart disease. When risk factors of the cases were compared to the controls, consanguinity, gestational diabetes, maternal age, and parity were found to significantly increase the incidence of TGA. Conclusion: Our study revealed significant risk factors for the development of transposition of great arteries including first degree consanguineous marriages, gestational diabetes, family history of congenital cardiac anomalies, and increasing maternal age and parity. These factors increased the risk by at least 2 folds.

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The Association Between Maternal Age and the Prevalence of Congenital Heart Disease in Newborns from 2016 to 2018 in Single Cardiac Center in Jeddah, Saudi Arabia

Cited by 11 publications

References 10 publications

Pattern of Congenital Heart Disease among Libyan Children: A Single Centre Study

Pattern of Congenital Heart Disease among Libyan Children: A Single Centre Study

Maternal age and the prevalence of congenital heart defects in Europe, 1995–2015: A register‐based study

Risk factors for transposition of the great arteries in Saudi population

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