The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events

Abstract

Abstract. Mean platelet volume (MPV), a marker of platelet activation, is a surrogate marker of platelet function and a potential mediator of the association between inflammation and thrombosis. The present retrospective study sought to investigate the association between MPV and the presence of thrombotic events (TEs) in patients with chronic atrial fibrillation (AF). A total of 114 consecutive patients with chronic AF were enrolled from a Chinese hospital. Individuals were divided into three groups: The AF+TE group (n=57, 33.1%), which comprised patients in AF with concomitant TEs; the AF group (n=57, 33.1%), which comprised patients in AF with no identifiable TEs, as confirmed by brain computed tomography, transesophageal echocardiography, or a combination of the two; and a control group (n=58, 33.7%), which consisted of patients who were in sinus rhythm. MPV, high-sensitivity C-reactive protein (hsCRP), D-dimer and the left atrial diameter (LAD) were analyzed in the 172 participants. The MPV level of patients in the AF+TE group was significantly higher than that of patients in the AF and control groups (P<0.05). In the correlation analysis, MPV levels were found to be positively correlated with LAD, D-dimer concentrations and hsCRP levels in patients with AF (r=0.960, P<0.05; r=0.896, P<0.05; and r=0.924, P<0.01, respectively). In the receiver operating characteristic curve analysis, the value for MPV levels required to detect TEs with a sensitivity of 77.5% and specificity of 78% was 10.5 femtoliter (fl). A high MPV level (>10.5 fl) was significantly associated with the occurrence of TEs (odds ratio, 3:1; 95% confidence interval, 1.6-5.1; P=0.000). The results of the present study suggest that an additional biomarker, MPV, has a predictive value for the presence of TEs in patients with AF. MPV may be a potential mediator between inflammation and thrombosis.

Relationship between red cell distribution width and mean platelet volume with new onset atrial fibrillation afteroff-pump coronary artery bypass grafting

“…Therefore, MPV may also be a response to infl ammation and thrombosis (9). It has been reported that an exaggerated infl ammatory response is associated with a higher risk of PoAF (20).…”

“…Activated platelets have larger volumes and contain wide range of vasoactive substances and prothrombotic factors. Therefore, MPV may also be a response to infl ammation and thrombosis (9). An increased MPV is associated with overall cerebrovascular and cardiovascular mortality rates (10).…”

Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease

“…There is a positive association between MPV and the severity of acute ischemic stroke [10], and MPV is useful for predicting the risk of ischemic stroke in patients with AF [11-15]. A recent case-control study showed that stroke patients with AF have a higher MPV than AF patients without a stroke history [13].…”

Increased expression of STIM1/Orai1 in platelets of stroke patients predictive of poor outcomes

“…A previous study reported abnormal platelet morphology, as well as increased soluble level and total level of platelet P‐selectin during acute IS . Recent studies have revealed that the mean platelet volume could function as a surrogate marker of platelet function and a potential mediator correlating inflammation with thrombosis . Platelet‐derived biomarkers for diagnosis and prognosis of IS are in high demand, but are still limited.…”