The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Huang, Zhen; Zhao, Xiujuan; Zhang, Huiyu; Guo, Liang; Qi, Hang; He, Xiaoqing; Zhu, Chenfeng; Ge, Shunna; Zhang, Jian

doi:10.1016/j.placenta.2020.06.017

Cited by 5 publications

(5 citation statements)

References 67 publications

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“…Telomere length data were adapted from Huang et al [56], as presented in Table 4. The percentage of the entropy generated in the pregnancy and lactation period, when compared to the non-pregnant woman's lifespan entropy is presented in Table 5.…”

Section: Resultsmentioning

confidence: 99%

Thermodynamic Assessment of the Impact of Pregnancy and Lactation on the Longevity of Women

Ulu

Öngel

Yılmaz

et al. 2022

International Journal of Thermodynamics

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Effects of the pregnancy and the following lactation periods on the lifespan entropy of the women has been evaluated. In the case of singleton pregnancy, a wealthy woman may generate 1.5% and in the case of twin pregnancy 2.1% of the total lifespan entropy of a non-pregnant wealthy women. In the case of a poor woman the singleton pregnancy, may generate 1.8% and in case of the twin pregnancy 2.1% of the total lifespan entropy generated by the non-pregnant wealthy woman. Results of the diet-based thermodynamic calculations for the poor women are compared with the demographic data collected across pre-industrial Europe and a good agreement was found.

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Section: Resultsmentioning

confidence: 99%

Thermodynamic Assessment of the Impact of Pregnancy and Lactation on the Longevity of Women

Ulu

Öngel

Yılmaz

et al. 2022

International Journal of Thermodynamics

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“…However, in cases of peritoneal endometriosis, interventions followed by hormonal therapy restored fertility in 62% of the cases, without ART [78 ▪ ]. Strikingly, in tubal pregnancies, which are a type of ectopic implantation caused by zygotes fixed outside the uterine cavity [79], the telomere length of placenta samples was similar to controls [80 ▪ ]. Finally, LTL was found to be shorter in women with idiopathic recurrent pregnancy loss [81].…”

Section: Uterine Aging and Implantationmentioning

confidence: 99%

Telomeres, aging and reproduction

Córdova-Oriz

Chico-Sordo

Varela

2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewWomen's fertility decay starts at the mid 30 s. However, the current delay of childbearing leads to ovarian aging and the need of assisted reproduction technologies (ART). Telomere biology is one of the main pathways involved in organismal aging. Thus, this review will focus on the knowledge acquired during the last 2 years about the telomere pathway and its influence on female fertility and the consequences for the newborn.Recent findingsNew research on telomere biology reaffirms the relationship of telomere attrition and female infertility. Shorter maternal telomeres, which could be aggravated by external factors, underly premature ovarian aging and other complications including preeclampsia, preterm birth and idiopathic pregnancy loss. Finally, the telomere length of the fetus or the newborn is also affected by external factors, such as stress and nutrition.SummaryRecent evidence shows that telomeres are implicated in most processes related to female fertility, embryo development and the newborn's health. Thus, telomere length and telomerase activity may be good biomarkers for early detection of ovarian and pregnancy failures, opening the possibility to use telomere therapies to try to solve the infertility situation.

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“…In tubal EP, the epithelial cells of the fallopian tube cannot undergo adequate decidualization to produce an appropriate microenvironment to support embryonic growth ( Liu et al., 2020b ), and most EP villi will be dysplastic or end with abortion ( Cunningham et al., 2008 ). In a previous study, we showed that EP villi exhibit excessive oxidative stress, decreased mitochondrial DNA copy number, and mitochondrial dysfunction compared to normal pregnancy (NP) villi ( Huang et al., 2020 ). Because mitochondria are the intracellular “energy factories”, mitochondrial dysfunction leads to metabolic dysfunction, triggers embryonic apoptosis, and prevents embryonic development ( Guerin, Mouatassim & Menezo, 2001 ).…”

Section: Introductionmentioning

confidence: 96%

Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy

Zhu

Zhao

Zhang

et al. 2023

PeerJ

Self Cite

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Objective To investigate whether the morphology, capillary number, and transcriptome expression profiles of ectopic pregnancy (EP) villi differ from those of normal pregnancy (NP) villi. Methods Hematoxylin-eosin (HE) and immunohistochemistry (IHC) staining for CD31 were conducted to compare differences in morphology and capillary number between EP and NP villi. Differentially expressed (DE) miRNAs and mRNAs were determined from transcriptome sequencing of both types of villi and used to construct a miRNA–mRNA network, from which hub genes were identified. Candidate DE-miRNAs and DE-mRNAs were validated by quantitative reverse transcription (qRT)-PCR. Correlations were identified between the number of capillaries and serum beta human chorionic gonadotropin (β-HCG) levels and between the expression levels of hub genes associated with angiogenesis and β-HCG levels. Results The mean and total cross-sectional areas of placental villi were significantly increased in EP compared with NP villi. Capillary density was greatly reduced in EP villi and was positively correlated with β-HCG levels. A total of 49 DE-miRNAs and 625 DE-mRNAs were identified from the sequencing data. An integrated analysis established a miRNA–mRNA network containing 32 DE-miRNAs and 103 DE-mRNAs. Based on the validation of hub mRNAs and miRNAs in the network, a regulatory pathway involving miR-491-5p–SLIT3 was discovered, which may have a role in the development of villous capillaries. Conclusion Villus morphology, capillary number, and miRNA/mRNA expression profiles in villous tissues were aberrant in EP placentas. Specifically, SLIT3, which is regulated by miR-491-5p, may contribute to the regulation of villous angiogenesis and was established as a putative predictor of chorionic villus development, providing a basis for future research.

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The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Cited by 5 publications

References 67 publications

Thermodynamic Assessment of the Impact of Pregnancy and Lactation on the Longevity of Women

Thermodynamic Assessment of the Impact of Pregnancy and Lactation on the Longevity of Women

Telomeres, aging and reproduction

Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy

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