The Association between Mortality Rates and Decreased Concentrations of Interleukin-10 and Interleukin-1 Receptor Antagonist in the Lung Fluids of Patients with the Adult Respiratory Distress Syndrome

Abstract

Low concentrations of the anti-inflammatory cytokines interleukin-10 and interleukin-1 receptor antagonist in bronchoalveolar lavage fluid obtained from patients with early ARDS are closely associated with poor prognosis. These findings support the hypothesis that failure to mount a localized intrapulmonary anti-inflammatory response early in the pathogenesis of ARDS contributes to more severe organ injury and worse prognosis. Our findings suggest that augmenting anti-inflammatory cytokine defenses would be a beneficial therapeutic approach to patients with ARDS and other inflammatory diseases.

Early Detection of Sepsis, MOF and Outcome Prediction in Severely Traumatized Patients

“…Based upon our results, IL-10 kinetics and its high serum levels in the groups with the poorer outcome are not in favor of its protective role as a cytokine, but it can be used as a good predictor of injury course and the outcome for some group of patients. [14,37,38] A signifficant correlation between non-pancreatic PLA2 levels and the development of respiratory insufficiency and hypotension in sepsis was found. [39] There is an obvious increase in non-pancreatic PLA2 levels in relation to mortality.…”

Lidocaine increases the anti‐inflammatory cytokine IL‐10 following mechanical ventilation in healthy mice

“…25 Low lung concentrations of IL-10 in patients with acute lung injury is an indication for development of adult respiratory distress syndrome. 28 Administration of IL-10 has shown protective effects in LPS-induced lung injury. 29 Interestingly, inhaled IL-10 attenuates biotrauma and mortality in a ventilator-induced lung injury model in rats.…”

Interleukin-1 Family: From Genes to Human Disease

“…The systemic level of IL-1β seems to reflect the severity of the lung injury rather than the diagnosis in different lung diseases 70 . The levels of IL-1β in BAL fluid from patients with ARDS did not differ between survivors and non-survivors, but low concentrations of anti-inflammatory cytokines IL-1Ra and IL-10 were associated with worse prognosis 68 . These observations support the hypothesis that inability to intensify the local anti-inflammatory activity early in the development of ARDS contributes to more severe lung injury and has prognostic significance.…”

“…In established acute respiratory distress syndrome (ARDS), elevated levels of both IL-1β and IL-1Ra were found in alveolar air space and plasma 67,68,69 . The systemic level of IL-1β seems to reflect the severity of the lung injury rather than the diagnosis in different lung diseases 70 .…”