The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee, Ae Li; Park, Yongsoon

doi:10.1159/000353120

Cited by 30 publications

(27 citation statements)

References 31 publications

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“…In support of this hypothesis, a case-control study found RA cases had significantly lower levels of EPA, and EPA+DHA in their red blood cell (RBC) membranes (a biomarker of n-3 FA status) compared with controls. 32 Furthermore, we found both n-3 FA supplement use and n-3 FA levels in RBC membranes were inversely associated with anti-CCP2 positivity in individuals without RA, but at risk for future RA. 33 However, it remains unclear whether n-3 FA exposure is associated with other RA-related autoantibodies, such as RF, and whether the association between n-3 FAs and RA-related autoantibodies is modified by SE, similar to the effect modification observed between SE and smoking on RA.…”

Section: Introductionmentioning

confidence: 64%

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

et al. 2016

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Objectives Previously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity. Methods The Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case–control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA% in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier. Results In the case–control study, increasing n-3 FA% in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95% CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95% CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95% CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2. Conclusions The potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.

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Section: Introductionmentioning

confidence: 64%

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

et al. 2016

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“…In contrast to these findings, erythrocyte levels of α-linolenic acid (ALA; 18:3n3), EPA 20:5n3, and the omega-3 index (EPA plus DHA) were found to be significantly lower in RA patients compared to healthy controls in a Korean population, although diet was not accounted for in this study. In addition, EPA and ALA were negatively associated with the risk of RA in Korean women [212].…”

Section: Studies Of Beneficial Effect Of Diet In Ramentioning

confidence: 94%

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Coras

Murillo-Saich

Gumá

2020

Cells

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related metabolites. In addition, recent literature has shown a link between diet-related metabolites and microbiome changes, since the gut microbiome is involved in the metabolism of some dietary ingredients. But diet and the gut microbiome are not the only factors linked to circulating pro- and anti-inflammatory metabolites. Other factors including smoking, associated comorbidities, and therapeutic drugs might also modify the circulating metabolomic profile and play a role in RA pathogenesis. This article summarizes what is known about circulating pro- and anti-inflammatory metabolites in RA. It also emphasizes factors that might be involved in their circulating concentrations and diet-related metabolites with a beneficial effect in RA.

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“…↓ Risk of asthma, rhinitis and aeroallergen sensitization [200,204,220,221] ↓ Asthma symptoms scores and ↓ responsiveness to acetylcholine [222] Improvement in pulmonary functions and ↓ use of short-acting inhaled bronchodilators and inhaled corticosteroids [290] ↑ Prevalence of wheeze [248] Adulthood ↓ Prevalence of asthma symptoms, airway hyperresponsiveness and ↑ asthma control and lung function [47,202,206,207,224,[226][227][228]230,233] ↓ Exhaled nitric oxide, ↓ serum eosinophils and ↑ FEV1 [225,229] ↓ Bronchodilator use, ↓ exhale nitric oxide and ↓ severity of exercise-induced bronchoconstriction [228,[231][232][233] Allergic Rhinitis Infancy and childhood ↓ Risk of rhinitis development [251,[254][255][256] Adulthood ↓ Prevalence [257,258] Atopic Dermatitis Pregnancy and lactation ↓ Incidence and intensity in the offspring [259,260]…”

Section: Asthmamentioning

confidence: 99%

“…Patients with rheumatic diseases usually have lower levels of PUFAs in serum [290]. It has been demonstrated that serum lipid profile is also altered in other rheumatic diseases, such as polymyositis (PM), dermatomyositis (DM), and Sjögren Syndrome (SS) [298].…”

Section: Rheumatic Diseasesmentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Cited by 30 publications

References 31 publications

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

The Influence of Dietary Fatty Acids on Immune Responses

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