The association between non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20–59: a population-based study in the United States

Hao, Jia-qi; Zhuang, Zi-xuan; Hu, Shu-yue; Zhang, Yu-jie; Zhang, Jia-wan; He, Feng-Jun; Wang, Rui; Zhuang, Wen; Wang, Mo-jin

doi:10.1186/s12944-024-02243-5

Lipids Health Dis

2024

DOI: 10.1186/s12944-024-02243-5

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The association between non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20–59: a population-based study in the United States

Jia-qi Hao,

Zi-xuan Zhuang,

Shu-yue Hu

et al.

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2024

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The ZJU index is associated with the risk of sarcopenia in American adults aged 20–59: a cross-sectional study

Hao,

Hu,

Zhuang

et al. 2024

Lipids Health Dis

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Background The ZJU index is an innovative computational method which integrates BMI, FBG, TG, and ALT to AST ratio. It strongly correlates with measures of lipid metabolism and glucose intolerance. No researches have yet explored the relationship between the ZJU index and sarcopenia. Methods We analyzed NHANES data from 2011 to 2018, dividing the ZJU index into quartiles. The association was investigated by adjusting for confounders using multivariable linear and logistic regression analysis. Results were visualized through RCS regression and threshold effect analyses. We conducted various subgroup and sensitivity analyses and plotted ROC curves to assess prediction efficacy, with the AUC as the measure of accuracy. Results As the ZJU index increases, the prevalence of sarcopenia also rises. Following the control of potential confounders via logistic regression analysis, our research identified a distinct relationship between the ZJU index and sarcopenia, which was statistically significant ( P < 0.001), with higher ZJU index values associated with increased risk (OR = 12.40, 95% CI: 8.46–18.17). Interaction analysis suggests that the relationship between the ZJU index and the risk of developing sarcopenia varies significantly between males and females across different ZJU index levels. ROC analysis for the ZJU index shows an AUC of 0.749. Conclusions: The ZJU index significantly correlates with a heightened risk of sarcopenia in Americans, suggesting its potential as a predictive marker for sarcopenia. Supplementary Information The online version contains supplementary material available at 10.1186/s12944-024-02373-w.

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The ZJU index is associated with the risk of sarcopenia in American adults aged 20–59: a cross-sectional study

Hao,

Hu,

Zhuang

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

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The association between non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20–59: a population-based study in the United States

Cited by 1 publication

References 35 publications

The ZJU index is associated with the risk of sarcopenia in American adults aged 20–59: a cross-sectional study

The ZJU index is associated with the risk of sarcopenia in American adults aged 20–59: a cross-sectional study

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