The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study

Guo, Hongyu; Zong, Shimiao; Yong, Li; Jiang, Yang; Qin, Ling; Zhou, Liang; Ren, Qiaoqiao; Gao, Xufang; Kang, Fayang; Huang, Wei; Chen, Jianyu; Zhang, Li

doi:10.3389/fpubh.2023.1260612

Front. Public Health

2023

DOI: 10.3389/fpubh.2023.1260612

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The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study

Hongyu Guo,

Shimiao Zong,

Li Yong

et al.

Abstract: ObjectiveTo investigate the association between the concentration of perchlorate in drinking water and the height and weight of children and adolescents in Sichuan Province.MethodsPerchlorate in the drinking water of 24 counties in Sichuan Province from 2021 to 2022 was detected and analyzed, 66 drinking water samples were collected, and the content of perchlorate in drinking water during the wet season and dry season was detected by ultra-high performance liquid chromatography in series. The linear mixed effe… Show more

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2024

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Cited by 2 publications

References 40 publications

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Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011–2018

Wang,

Zhang,

et al. 2024

Nutrients

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Background: Perchlorate, nitrate, and thiocyanate are widely recognized as endocrine disrupting chemicals, which are closely related to thyroid function. Animal and human studies show a correlation between thyroid hormone and bone mineral density (BMD). However, it remains unknown whether perchlorate, nitrate, and thiocyanate were associated with BMD. This study aimed to explore the association between perchlorate, nitrate, and thiocyanate exposure with BMD. Method: A cross-sectional analysis among 5607 participants from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) was conducted in the present study. Perchlorate, nitrate, and thiocyanate were detected in urine by ion chromatography. Survey-weighted generalized linear regression, restricted cubic splines, and qgcomp models were used to assess the association of BMDs with single and mixed perchlorate, nitrate, and thiocyanate exposures. In addition, age, gender, and BMI stratified these associations. Results: Negative associations were found between perchlorate and nitrate with BMDs. Furthermore, based on the qgcomp model results, the combined association of perchlorate, nitrate, and thiocyanate exposure was negatively associated with BMDs (β = −0.017, 95% CI: −0.041, −0.024 for total BMD; β = −0.017, 95% CI: −0.029, −0.005 for lumbar BMD). Additionally, there was a significant effect after gender, age, and BMI stratification between perchlorate, nitrate, and thiocyanate with BMDs in the normal weight group (β = −0.015, 95% CI: −0.020, −0.011 for total BMD; β = −0.022, 95% CI: −0.028, −0.016 for lumbar BMD) and children and adolescents group (β = −0.025, 95% CI: −0.031, −0.019 for total BMD; β −0.017, 95% CI: −0.029, −0.005 for lumbar BMD). Conclusions: The present study indicated a negative correlation between BMDs and urinary perchlorate, nitrate, and thiocyanate levels, with nitrate being the main contributor to the mixture effect. People with normal weight and children and adolescents were more likely to be affected.

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Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011–2018

Wang,

Zhang,

et al. 2024

Nutrients

View full text Add to dashboard Cite

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The Modifying Effects of Lifestyle Behaviors on the Association Between Drinking Water Micronutrients and BMI Status Among Children and Adolescents Aged 7~17: A Population-Based Regional Surveillance in 2022

Chen,

Zhang,

Jiang

et al. 2024

Nutrients

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Background: This study aims to investigate the potential modifying effects of lifestyle behavior on the association between drinking water micronutrients and body mass index (BMI) in a large population of children and adolescents. Methods: Data of the present analysis came from a comprehensive regional large-scale surveillance study in 2022, involving 172,880 children and adolescents (50.71% boys vs. 49.29% girls) aged seven to seventeen. A restricted cubic spline (RCS) analysis was utilized to examine the exposure-response association of regular drinking water indices (including fluoride, nitrate nitrogen, pH, chloride, sulfates, and total dissolved solids (TDS), total hardness (TH), and chemical oxygen demand (COD)) with BMI. Generalized linear model and logistic regression were conducted to relate BMI and quartiles of drinking water micronutrients. Results: Our findings reveal a nonlinear association between nitrate nitrogen (P for nonlinear < 0.001) and pH (P for nonlinear < 0.001) with BMI. High TH and COD levels significantly increase BMI. Notably, fluoride and chloride were associated with BMI Z-scores but not with overweight and obesity (OB). The BMI Z-score showed a more pronounced association with low and high pH levels in girls. For urban participants, increased TH levels were associated with a higher risk of OB. This study also found that adopting healthy lifestyles could mitigate the negative effects of fluoride, chloride, and sulfate on BMI Z-scores. Conclusions: This large surveillance study provides new insights into the complex interplay between drinking water micronutrients and BMI in children and adolescents. The association of various drinking water parameters on BMI varies, necessitating ongoing focus on their effects, particularly among girls and urban individuals. Healthy lifestyle behavior could mitigate the effects of fluoride, chloride, and sulfate on BMI Z-score.

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The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study

Cited by 2 publications

References 40 publications

Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011–2018

Associations of Perchlorate, Nitrate, and Thiocyanate with Bone Mineral Density in the US General Population: A Multi-Cycle Study of NHANES 2011–2018

The Modifying Effects of Lifestyle Behaviors on the Association Between Drinking Water Micronutrients and BMI Status Among Children and Adolescents Aged 7~17: A Population-Based Regional Surveillance in 2022

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