The association between persistent eosinophilia and asthma in childhood is independent of atopic status

Karakoç, Fazilet; Remes, ST; Martinez, FD; Wright, Anne L.

doi:10.1046/j.0022-0477.2001.01273.x

Cited by 44 publications

(51 citation statements)

References 21 publications

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“…Parental asthma is associated with increased and persistent peripheral blood eosinophilia, which is a characterizing feature of the presence of a T H 2-mediated response and which may be responsible for chronic asthma and allergy. 34 Finally, our results confirm previous findings about the existence of a gender reversal during puberty caused by an increase in reported asthma in women and a decrease in men. It has been suggested that airway caliber, in addition to hormonal factors, could play an important role in explaining the different pattern of incidence in men and women.…”

Section: Discussionsupporting

confidence: 93%

Influence of early life exposures on incidence and remission of asthma throughout life☆

Marco

Pattaro²,

Locatelli³

et al. 2004

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 93%

Influence of early life exposures on incidence and remission of asthma throughout life☆

Marco

Pattaro²,

Locatelli³

et al. 2004

Journal of Allergy and Clinical Immunology

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“…A different mechanism may be present in persistent wheezers, given their different prognoses. We (5,15,16) and others (17)(18)(19) have reported that children with persistent wheeze are more likely than transient early wheezers to have high serum IgE levels, eosinophilia, and skin test reactivity to local aeroallergens. Lowe and coworkers (20) showed that, regardless of the development of early respiratory symptoms, children with a strong family history of asthma who had become sensitized to local allergens had significantly lower specific airway conductance at age 3 yr compared with nonsensitized children.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Asthma and Wheezing in the First 6 Years of Life

Morgan

Stern

Sherrill

et al. 2005

Am J Respir Crit Care Med

603

417

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Rationale: The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before age 3 yr and active wheeze at age 6 yr: never wheezers (n ϭ 425), transient early wheezers (n ϭ 164), persistent wheezers (n ϭ 113), and lateonset wheezers (n ϭ 124). Objective: We sought to determine the prognosis for these phenotypes, with reference to lung function and symptoms, through adolescence. Methods: Current wheeze was assessed by questionnaire, lung function was measured by conventional spirometry, and atopy was determined by skin prick tests. Results: The prevalence of atopy and wheeze by age 16 yr was similar for never and transient wheezers and for persistent and late-onset wheezers. Both transient early, and persistent wheezers had significantly lower FEF 25-75 (-259 ml/s, p Ͻ 0.001, and -260 ml/s, p ϭ 0.001, respectively), FEV 1 (-75 ml, p ϭ 0.02, and -87 ml, p ϭ 0.03, respectively), and FEV 1 :FVC ratio (-1.9%, p ϭ 0.002, and -2.5%, p ϭ 0.001, respectively) through age 16 yr compared with never wheezers. Late-onset wheezers had levels of lung function similar to those of never wheezers through age 16 yr. There was no significant change in lung function among subjects with any of the four phenotypes, relative to their peers, from age 6 to 16 yr. Conclusion: Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthmalike symptoms during the preschool years.

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“…In a study by Karakoc et al [20], eosinophilia was linked to persistent asthma independently of atopia during childhood. This finding suggests that there is a strong correlation between parental asthma and eosinophilia; thus, genetics can be an important determinant of the eosinophilic response [20]. In our study, higher serum IgE levels and eosinophil counts were detected in the wheezing group compared to controls, although this finding was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Decreased Levels of Lipoxin A4 and Annexin A1 in Wheezy Infants

Gungor

Tahan

Gökahmetoğlu

et al. 2014

Int Arch Allergy Immunol

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Objective: Wheezing is a common and challenging health issue in infancy and early childhood. Asthma diagnosis is frequent in patients with a history of recurrent wheezing. A relationship has been reported between asthma and anti-inflammatory mediators such as lipoxin A4 and annexin A1. However, this remains uncertain in wheezy infants. The aim of the present study was to determine lipoxin A4 and annexin A1 levels in wheezy infants. Materials and Methods: Eighty-seven patients aged 6-36 months were included in this study. Demographic characteristics, clinical features, laboratory data, clinical diagnoses, and treatments, if present, were recorded. Patients were divided into 2 groups: patients with wheezing (n = 59) and healthy controls (n = 28). Blood samples were taken and lipoxin A4 and annexin A1 levels were evaluated by ELISA. Results: Lipoxin A4 and annexin A1 levels were significantly lower in the wheezing group than in the control group (p < 0.05). A significant correlation was found between the serum total immunoglobulin E (IgE) level and the percentage and absolute number of eosinophils (p < 0.05). No significant correlation was found in terms of lipoxin A4 and annexin A1 levels, the serum total IgE level, and the percentage and absolute number of eosinophils among groups (p > 0.05). Conclusion: This is the first study to assess lipoxin A4 and annexin A1 levels in wheezy infants. The levels of lipoxin A4 and annexin A1 were found to be low in wheezy infants. We hope that these results will lead to novel therapeutic options for asthma in cases where an optimal treatment modality is lacking.

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The association between persistent eosinophilia and asthma in childhood is independent of atopic status

Abstract: Longitudinal eosinophil levels are linearly associated with chronic asthma in childhood, independent of atopy. The strong association between parental asthma and eosinophil status suggests that genetic background may be an important determinant of eosinophilic response.

Cited by 44 publications

References 21 publications

Influence of early life exposures on incidence and remission of asthma throughout life☆

Influence of early life exposures on incidence and remission of asthma throughout life☆

Outcome of Asthma and Wheezing in the First 6 Years of Life

Decreased Levels of Lipoxin A4 and Annexin A1 in Wheezy Infants

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