The association between PON1 and GSTM1 genetic variation with methylation of p16 gene promoter among Javanese farmers exposed to pesticides at Magelang Regency, Central Java, Indonesia

Ratna, Maya G.; Nugrahaningsih, Dwi Aris Agung; Sholikhah, Eti Nurwening; Dwianingsih, Ery Kus; Malueka, Rusdy Ghazali

doi:10.1016/j.heliyon.2020.e03993

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…Similar results were found for CDKN2A , which showed hypermethylation in the promoter region due to pesticide mixture exposure in two studies [ 23 , 24 ]. Herrera-Moreno et al .…”

Section: Resultssupporting

confidence: 86%

Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis

Rohr,

Karen,

Francisco

et al. 2024

Environmental Epigenetics

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In recent decades, the use of pesticides in agriculture has increased dramatically. This has resulted in these substances being widely dispersed in the environment, contaminating both exposed workers, communities living near agricultural areas, and via contaminated foodstuffs. In addition to acute poisoning, chronic exposure to pesticides can lead to molecular changes that are becoming better understood. Therefore, the aim of this study was to assess, through a systematic review of the literature, what epigenetic alterations are associated with pesticide exposure. We performed a systematic review and meta-analysis including case-control, cohort, and cross-sectional observational epidemiological studies to verify the epigenetic changes, such as DNA methylation, histone modification, and differential microRNA expression, in humans that had been exposed to any type of pesticide. Articles published between the years 2005 to 2020 were collected. Two different reviewers performed a blind selection of the studies using the Rayyan QCRI software. Post-completion, the data of selected articles were extracted and analyzed. Most of the 28 articles included evaluated global DNA methylation levels, and the most commonly reported epigenetic modification in response to pesticide exposure was global DNA hypomethylation. The meta-analysis revealed a significant negative correlation between Alu methylation levels and β-HCH, pp’-DDT, and pp’-DDE levels. In addition, some specific genes were reported to be hypermethylated in promoter regions, such as CDKN2AIGF2, WRAP53α, and CDH1, while CDKN2B and H19 were hypomethylated due to pesticide exposure. The expression of microRNAs was also altered in response to pesticides, as miR-223, -518d-3p, -597, -517b, and 133b that are associated with many human diseases. Therefore, this study provides evidence that pesticide exposure could lead to epigenetic modifications, possibly altering global and gene-specific methylation levels, epigenome-wide methylation, and micro-RNA differential expression.

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“…Similar results were found for CDKN2A , which showed hypermethylation in the promoter region due to pesticide mixture exposure in two studies [ 23 , 24 ]. Herrera-Moreno et al .…”

Section: Resultssupporting

confidence: 86%

Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis

Rohr,

Karen,

Francisco

et al. 2024

Environmental Epigenetics

View full text Add to dashboard Cite

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“…The prevalence of GSTM1 null genotype in Japan is 47.6%, in Korea is 52.1%, in Singapore is 56.2%, in Philippines is 51.7%, in India is 29.6%, in Afghanistan is 46%, and in Iran is 40.6% [ 66 ]. Our study conducted in Central Java, Indonesia showed that the prevalence of the GSTM1 null genotype among Javanese is 82.1% [ 67 ]. In unrelated subjects in Iran, the prevalence of GSTM1 null genotype is 43.8–56% [ 68 ].…”

Section: Genetic Variation Of Cytosolic Gstmentioning

confidence: 99%

A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems

Nugrahaningsih

Wihadmadyatami

Widyarini

et al. 2023

International Journal of Genomics

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Air pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1’s null genotype role in modifying the relationship between air pollution and health problems.

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“…Using these chemicals may harm the environment and the long-term viability of the products. In addition, research indicates that excessive use of pesticides and chemicals can contaminate soil and water (Utami et al, 2020), as well as significantly impact the health of farmers (Ratna et al, 2020).…”

Section: ) Organic Farmingmentioning

confidence: 99%

Environmental education for the younger generation at the Taman Keanekaragam Hayati Subang

Nugroho

Juliani²,

Rahayu³

et al. 2022

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The integration of learning activities in schools and environmental education is considered capable of increasing students’ knowledge, understanding, and positive behavior towards the environment. The aim of the environmental education program at Taman Kehati Subang was to investigate its role in supporting environmental education activities of the students of SMK Tri Surya Bangsa, Subang. It was conducted on August 21, 2020 and was attended by 10 representatives’ students of class X, XI, and XII and 2 accompanying teachers. Outdoor activities, games, and field practice were used to deliver the material. It includes organic cultivation, biodiversity conservation, nurseries and compost making, cipondoh water sources, and soil and water conservation. Our evaluation showed that students hold high agreement that Taman Kehati has various types of plants and suitable to support environmental education activities in schools. Students assessed that a visit to Taman Kehati provided new experiences that could increase their knowledge of environmentally natural resource management. Delivering material with a combination of outdoor activities, field practice, and games makes them easy to be understood and can be practiced daily. It can be concluded that students and teachers generally consider that Taman Kehati is suitable to support the integration of learning in schools and environmental education. Students were very satisfied with the environmental education activities at Taman Kehati, Subang

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The association between PON1 and GSTM1 genetic variation with methylation of p16 gene promoter among Javanese farmers exposed to pesticides at Magelang Regency, Central Java, Indonesia

Cited by 4 publications

References 67 publications

Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis

Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis

A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems

Environmental education for the younger generation at the Taman Keanekaragam Hayati Subang

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