The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts

Zhang, Qi; Chen, Xinzhen; Huang, Xin; Wang, Min; Wu, Jing

doi:10.1016/j.neuro.2019.04.007

Cited by 82 publications

(53 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, a recent systematic review based on exposure levels in the general population reported that all but MEP had moderate or greater evidence of male reproductive effects, including decreased testosterone levels (Radke et al 2018). Phthalate's sex-specific effects on a range of neurodevelopmental outcomes were also shown in human studies as well, with stronger evidence for potential neurobehavioral effects in boys, especially for MBP (reviewed by Ejaredar et al 2015;Zhang et al 2019).…”

Section: Environmental Health Perspectivesmentioning

confidence: 93%

“…Because previous studies showed potential sexually dimorphic associations between phthalates and neurodevelopmental outcomes (Kim et al 2011;Shin et al 2018;Zhang et al 2019), we examined sex-specific associations by including a product interaction term between child sex and phthalate concentrations. We also examined whether prenatal FA supplementation modified the association between urinary phthalate concentrations and SRS scores using the same approach.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…In the present study, we examined the relationship between first trimester gestational urinary phthalate concentrations and the development of children's autistic traits as measured by the SRS-2 at 3-4 years of age in a multisite Canadian prospective pregnancy cohort. We also examined effect modification by child sex because phthalates are suspected to have sexually dimorphic neurodevelopmental effects (Ejaredar et al 2015;Zhang et al 2019). Finally, we investigated effect modification by gestational FA supplementation to examine whether previously reported findings for pesticides and air pollutants extend to phthalates.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children

Oulhote

Lanphear

Braun

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

Section: Environmental Health Perspectivesmentioning

confidence: 93%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children

Oulhote

Lanphear

Braun

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…However, reported effects are not fully consistent across the different phthalate compounds, the neuropsychological domains implicated and the sex-specificity of the effects (Bellinger, 2013;Miodovnik et al, 2014;Ejaredar et al, 2015;Katsikantami et al, 2016;Vrijheid et al, 2016;Braun, 2017;Lee et al, 2018;Bornehag et al, 2018;Zhang et al 2019).…”

Section: Introductionmentioning

confidence: 98%

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

Jankowska

Polańska

Hanke

et al. 2019

Environmental Research

View full text Add to dashboard Cite

Phthalates are among of the most frequently investigated environmental chemicals influencing children's health and particularly their neuropsychological development. However, the reported effects of these compounds on child behavior, cognitive and psychomotor outcome are not fully consistent. The aim of this study is to evaluate the associations between prenatal and early postnatal phthalate exposures and child neurodevelopment at age of 7 years. A total of 134 mother-child pairs from Polish Mother and Child cohort (REPRO_PL) constitute the basis for current analysis. Eleven phthalate metabolites were measured in urine samples collected from mothers in the 3 rd trimester of pregnancy and from children at the age of 2 years. Child neuropsychological development at early school age (7 years) was assessed by both the Strengths and Difficulties Questionnaire (SDQ) filled by mothers and the Polish adaptation of the Intelligence and Development Scales (IDS) performed by psychologists. MEP concentration during pregnancy was significantly associated with increased risk of peer relationship problems in SDQ (OR=2.7, p=0.03). The concentration of two phthalate metabolites (oxo-MEHP and MiBP) in the urine collected from mothers during pregnancy, as well as MnBP concentration at age of 2 years were of borderline significance on prosocial behaviour and hyperactivity/inattention problems, respectively (OR=2.6, p=0.08; OR=2.2, p=0.07; OR=2.6, p=0.08). The results of the IDS analyses focused on child's cognitive and psychomotor development are not fully conclusive. Negative associations were evident between some phthalates in early childhood period and fluid intelligence and cognition (MEP: β=-5.2; p=0.006; β=-4.2; p=0.006; MnBP: β=-4.9; p=0.03; β=-4.0; p=0.03; respectively) and psychomotor skills (OH-MiNP: β=-1.2; p=0.07), while positive associations have been found in the prenatal period (MEP: β=2.9; p=0.07 for cognition; β=1.4; p=0.06 for language skills; oxo-MEHP: β=3.6; p=0.03 for fluid intelligence; β=2.9; p=0.03 for cognition; β=1.2; p=0.08 for psychomotor development). Further studies are required in order to elucidate which are the most critical periods of phthalate exposure on children's neurodevelopmental outcomes.

show abstract

“…Behavior impairments are particularly more prevalent in boys (Q. Zhang et al, 2019). Furthermore, Hyland and colleagues conducted a cohort study in which they evaluated the relationship between maternal urinary phthalate metabolite concentrations and neurodevelopmental outcomes in subjects from age 7 through 16 (Hyland et al, 2019).…”

Section: Phthalates and Cns Effectsmentioning

confidence: 99%

The detrimental effect of microplastics on critical periods of development in the neuroendocrine system

Solleiro‐Villavicencio

León

Río-Araiza

et al. 2020

Birth Defects Research

View full text Add to dashboard Cite

As a result of human socioeconomic activity, industrial wastes have increased alarmingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. Two broad classes of plastic-related chemicals are of critical concern for human health-bisphenol-A or BPA, and additives used in the synthesis of plastics, which are known as phthalates. Our exposure to them is ubiquitous because they are used in the production of materials that we use daily such as polycarbonate plastics, epoxy resins, flooring, automotive parts, medical devices, dental sealants, and children's toys. Since these compounds are not covalently bound to the products, they easily leach from them, leading to high human exposure. Both, BPA and phthalates, are endocrine-disruptor compounds (EDCs) with steroidogenic activity, and can bind to different receptors, such as estrogen, androgen, PPAR-γ, and AhR. These pathways are part of the complex regulatory neuroendocrine network, since its cellular components not only express neuroendocrine receptors, but synthesize and respond to several hormones and other endocrine ligands. On the other hand, the effects of BPA and phthalates on neuroendocrine diseases have been poorly studied and the available data are inconclusive. This can be attributed to the enormous variety of animal models and the different doses used in experiments or levels found in humans. However, what is clear is that exposure to both EDCs during critical life stages induces many changes in the neuroendocrine system of exposed humans that are correlated with different reproductive and neurological diseases.

show abstract

The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts

Cited by 82 publications

References 96 publications

Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children

Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children

Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years – Polish Mother and Child Cohort

The detrimental effect of microplastics on critical periods of development in the neuroendocrine system

Contact Info

Product

Resources

About