More than eight hundred eight thousand Americans are affected by end-stage renal failure (ESRD); out of them, 31% have undergone a kidney transplant. Even though this transplantation comes with potential risk factors, there is a significant chance that this transplant will save the patient's life. There are legitimate benefits, however, there are concerns over the quality of life following the transplant. The main aim of the study is to find if the quality of life is affected post transplantation. If so to how much extend it is affected? Using keyword and Medical Subject Heading (Mesh) combinations five databases that were screened. The keywords used are kidney transplantation, renal transplant, quality of life, well-being. The articles were put through a rigorous screening and quality assessment process. This review is based on papers published within the last ten years, from 2013 to 2023, in English. We examined human study on kidney transplant recipients who had poor quality of life (QoL) post transplantation. This systematic review includes a total of 14 papers. This systematic review strongly concludes that in post renal transplantation patients' quality of life is compromised in both psychological and economical aspect. Consequently, further study on this crucial topic is required.