The Association between Self-reported Osteoporosis and Chinese Medicine-Constitution Questionnaire – A Cross-Sectional Taiwan Biobank Study

Abstract

Background: Constitutional medicine was as an example of earlier medicine evidence of Chinese Medicine (CM). CM-Constitutional Questionnaire (CM-CQ) commonly considered as the observed various phenotypes as phenome. However, the comprehensive associations between self-reported disease outcomes and questionnaires of CM-CQ remained uncertain. Methods: Taiwan Biobank has begun the collection of these cancer-free volunteers, aged 30-70 with these questionnaires, self-reported disease history, clinical examinations, and genetic information from 2012 as baseline enrollment. This community-, cross-sectional study was conducted by part of Taiwan Biobank and compared the associations among CM-CQ, which reflect these constitutional variables as individual markers.Results: The present study conducted by using 1,998 volunteers (2 withdraw) from Taiwan Biobank. Which separately assessed the associations among 32 diseases and 44 items of CM-CQ questions using the binomial logistic regression model. There were 6 CM-CQ questions with a significant association of self-reported osteoporosis in all CM-CQ. Interestingly, we found that these 6 CM-CQ questions shown a significant association with osteoporosis, even which adjusted with false discovery rate (adjusted p <0.05). The Q1, Q22, and Q37 demonstrated with considerably adjusted p-value and the other CM-CQ, which involved in Q14, Q16, and Q21 shown borderline relation to self-reported osteoporosis, which was existed less residual effect with smoking and drinking habits. Conclusion: This study generated real-world evidence of national biobank for clarified associations between clinical symptom and self-reported diseases. The exploration of self-reported disease-related CM-CQ for further companion diagnostic indicators via comprehensive community-based Taiwan Biobank study should be a possibility.