The association between serum osteocalcin levels and metabolic syndrome in Koreans

Bae, Sung Jin; Choe, Jun-Ho; Chung, Young–Hwa; Kim, Bum Joon; Lee, S. H.; Kim, H. Y.; Koh, Jung‐Min; Kim, H. K.; Kim, G. S.

doi:10.1007/s00198-010-1504-y

Cited by 41 publications

(34 citation statements)

References 26 publications

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“…These studies found that osteocalcin was negatively correlated with fasting plasma glucose, insulin, and glycohemoglobin A1c [17]. Beyond negative correlations with glucose metabolism, some studies also report negative correlations between osteocalcin and broader parameters like body mass index, insulin resistance, adipokine levels, and fat mass, suggesting a link with metabolic syndrome [18][19][20][21][22][23][24][25][26][27]. Our data provide direct support for the notion that in humans, uncarboxylated osteocalcin regulates blood glucose and energy metabolism.…”

Section: Discussionsupporting

confidence: 70%

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

et al. 2011

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Osteocalcin is a hormone secreted by osteoblasts, which regulates energy metabolism by increasing β-cell proliferation, insulin secretion, insulin sensitivity, and energy expenditure. This has been demonstrated in mice, but to date, the evidence implicating osteocalcin in the regulation of energy metabolism in humans are indirect. To address this question more directly, we asked whether a benign osteoblastic tumor, such as osteoma osteoid in young adults, may secrete osteocalcin. The study was designed to assess the effect of surgical resection of osteoid osteoma on osteocalcin and blood glucose levels in comparison with patients undergoing knee surgery and healthy volunteers. Blood collections were performed the day of surgery and the following morning after overnight fasting. Patients and controls were recruited in the orthopedic surgery department of New York Presbiterian Hospital, NY-USA and Hospices Civils de Lyon, France. Seven young males were included in the study: two had osteoid osteoma, two underwent knee surgery, and three were healthy volunteers. After resection of the osteoid osteomas, we observed a decrease of osteocalcin by 62% and 30% from the initial levels. Simultaneously, blood glucose increased respectively by 32% and 15%. Bone turnover markers were not affected. This case study shows for the first time that osteocalcin in humans affects blood glucose level. This study also suggests that ostoid osteoma may be considered, at least in part, as an osteocalcinoma.

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Section: Discussionsupporting

confidence: 70%

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

et al. 2011

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“…Inflammatory cytokines, endogenous sex hormones, lipid oxidation, vitamin K deficiency, and vitamin D deficiency have been implicated as possible mediators in the progression of both conditions (33). The inverse association observed in men is plausible in light of the growing body of evidence from studies in community-dwelling populations (9,10,11,12,13,14,15), including our own study (16), that consistently confirm a relationship between low circulating OC levels and established predictors of CVD. These include central adiposity, hypertension, and unfavorable lipid composition.…”

Section: Discussionsupporting

confidence: 56%

“…Knockout mice lacking Oc showed decreased b-cell proliferation, glucose intolerance, and insulin resistance (7). This notion is supported by recent human studies, which have consistently reported inverse associations between circulating OC and components of the metabolic syndrome in community-dwelling populations (9,10,11,12,13,14,15). A low plasma OC concentration was strongly associated with a higher prevalence of metabolic syndrome in the Longitudinal Aging Study Amsterdam (LASA) (16).…”

Section: Introductionmentioning

confidence: 74%

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Holvik

Schoor

Eekhoff

et al. 2014

European Journal of Endocrinology

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Objective: The role of osteocalcin (OC) in cardiovascular disease (CVD) is unresolved. We aimed to study the association between plasma OC concentrations and the risk of non-fatal and fatal CVDs. We also aimed to investigate whether such an association, if present, would be mediated by established metabolic risk factors. Design: A population-based longitudinal cohort study. Methods: In 1995/1996, OC was determined in blood samples drawn from 1319 subjects aged 65-88 years participating in the Longitudinal Aging Study Amsterdam in 1995/1996. The self-reported CVD events were collected every 3 years until 2005/2006, and CVD deaths until 1st January 2007. Cox proportional hazards regression was performed, considering potential confounders (smoking, physical activity, and BMI) and mediators (blood pressure, plasma triglycerides, total and HDL cholesterol, fructosamine, and aortic calcification). Results: During the median 4.1 years follow-up, 709 subjects (53.8%) suffered a CVD event. There was no overall association between OC and CVD: hazard ratio (HR) was 0.97 (95% CI 0.90-1.04) per nmol/l higher plasma OC, adjusted for age and sex. There was a statistical interaction between plasma OC, age, and sex on CVD (PZ0.014). In those subjects aged R75 years, age-adjusted HRs (95% CI) were 0.86 (0.75-0.99) in men and 1.16 (1.03-1.31) in women per nmol/l higher plasma OC. Adjustment for covariates only slightly attenuated the association in older-old men, but did not affect the association in older-old women. Conclusion: A higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. We found no evidence that this was mediated by arterial calcification or metabolic risk factors.

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“…Cross-sectional studies have generally shown that higher osteocalcin levels correlate with better glucose metabolism: osteocalcin has a negative association with BMI, fasting glucose and insulin, metabolic syndrome and insulin resistance and leptin and is positively correlated with adiponectin (6,(27)(28)(29). In a prospective study, higher baseline osteocalcin was associated with lower increase in fasting plasma glucose at 3-yr follow-up (28).…”

Section: Discussionmentioning

confidence: 94%

Cross-Sectional Evidence of a Signaling Pathway from Bone Homeostasis to Glucose Metabolism

Gravenstein

Napora

Short

et al. 2011

The Journal of Clinical Endocrinology & Metabolism

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The association between serum osteocalcin levels and metabolic syndrome in Koreans

Abstract: These findings suggest that osteocalcin is associated with MS, independently of glucose metabolism.

Cited by 41 publications

References 26 publications

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Cross-Sectional Evidence of a Signaling Pathway from Bone Homeostasis to Glucose Metabolism

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