The association between serum selenium level and gestational diabetes mellitus: A systematic review and meta‐analysis

Xu, Wenhui; Tang, Yi‐Wei; Ye, Ji; Yu, Haoyong; Li, Yueting; Chun-ji, Piao; Xie, Lin

doi:10.1002/dmrr.3522

Cited by 14 publications

(13 citation statements)

References 49 publications

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“…Compared with the previous research, we have the following innovations: Firstly, our research has developed clearer inclusion and exclusion criteria. Different from the research of Xu et al ( 21 ), we exclude some studies that do not meet the inclusion criteria, and the results are more convincing. For example, in the paper published by Al-Saleh et al ( 41 ) in 2005, the subjects of their study were women with insulin-dependent diabetes before pregnancy, not pregnant women with GDM, so this study was not included in our research.…”

Section: Discussionmentioning

confidence: 99%

“…We have made amendments to this and made further analysis according to the type of study. In addition, we conducted subgroup analyses from different perspectives not involved in previous studies ( 19 – 21 ), such as study type, study completion time, GDM diagnostic criteria, blood selenium measurement methods, quality of included studies, and study sample size, to further explore the source of heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

“…A growing number of studies on the association between selenium and diabetes have been conducted; however, controversial findings have been reported. Previous meta-analyses on the association between selenium levels and GDM by Askari ( 19 ), Kong ( 20 ), and Xu et al ( 21 ) only included cross-sectional studies and case-control studies. Therefore, in our systematic review and meta-analysis, we searched the relevant literature and included other higher quality prospective studies (prospective cohort studies and nested case-control studies) to comprehensively analyze the association between maternal blood selenium levels and GDM and draw more reliable conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Association between blood selenium levels and gestational diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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IntroductionThe association between blood (serum or plasma) selenium concentrations and gestational diabetes mellitus (GDM) has been evaluated in some studies. However, the reported findings are debatable, and only case-control and cross-sectional studies were included.ObjectiveThis research aimed to assess the association between blood selenium levels and GDM by analyzing existing literature. To provide a reference for the prevention and treatment of GDM, we included prospective studies which are not included in previous studies to collate more high-quality evidence and better test the etiological hypothesis between blood Se concentrations and GDM.MethodsThe PubMed, EMBASE, and Web of Science databases were retrieved for literature up to September 2022, and relevant references were manually searched. Raw data from relevant studies were extracted, and a random effect model was adopted for meta-analysis. The total effects were reported as weighted mean differences. All data were analyzed using Stata 16.0 software.ResultsFourteen studies involving 890 pregnant women with GDM and 1618 healthy pregnant women were incorporated in the meta-analysis. Pregnancies with GDM had significantly lower blood selenium levels than those with normal glucose tolerance (weighted mean difference = −8.11; 95% confidence interval: −12.68 to −3.54, P = 0.001). Subgroup analyses showed that the association between blood selenium levels and GDM was consistent in the residents of Asia and Africa, but not in European. This trend was significant in the second and third trimester subgroups, but not in the first trimester subgroup. Articles published in 2006–2015 also showed this trend, but those published before 2005 and 2016–2019 did not show significant results. This difference was evident in non-prospective studies, but not significant in prospective studies. Studies using the Carpenter and Coustan diagnostic criteria were consistent with this trend, whereas studies using other diagnostic criteria found no differences. In addition, in terms of blood selenium measurement methods, atomic absorption spectrometry showed more significant differences than other methods. In the subgroup analysis based on the sample size of included studies and the quality of the studies, each subgroup showed statistical differences.ConclusionLower blood selenium concentrations are associated with GDM as shown in our study. Therefore, supplementing an appropriate amount of selenium may be helpful for GDM prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between blood selenium levels and gestational diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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“…Over the last decade, increasing attention has been paid to the selenium status in patients with various cardiometabolic diseases and the association between selenium status and mortality risk of various cardiometabolic diseases. Several meta-analyses have indicated that individuals with cardiometabolic diseases tend to have lower selenium levels than healthy individuals [50][51][52], and that selenium levels are negatively associated with mortality among patients with MS, T2DM, and CVD [53][54][55]. Alterations in the metabolism of glucose and lipids characterize metabolic disorders [56].…”

Section: Discussionmentioning

confidence: 99%

Potential Benefits of Selenium Supplementation in Reducing Insulin Resistance in Patients with Cardiometabolic Diseases: A Systematic Review and Meta-Analysis

et al. 2022

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Background: Selenium is a trace element that has been reported to be effective in regulating glucose and lipid metabolism. However, there is conflicting evidence from different clinical trials of selenium supplementation in treating cardiometabolic diseases (CMDs). Objective: This meta-analysis aimed to identify the effects of selenium supplementation on insulin resistance, glucose homeostasis, and lipid profiles in patients with CMDs. Methods: Randomized controlled trials (RCTs) of selenium supplementation for treating CMDs were screened in five electronic databases. Insulin levels, homeostatic model assessment of insulin resistance (HOMA-IR), fasting plasma glucose (FPG), and glycosylated hemoglobin A1C (HbA1c) were defined as the primary outcome markers, and lipid profiles were considered the secondary outcome markers. Results: Ten studies involving 526 participants were included in the meta-analysis. The results suggested that selenium supplementation significantly reduced serum insulin levels (standardized men difference [SMD]: −0.53; 95% confidence interval [CI] [−0.84, −0.21], p = 0.001, I2 = 68%) and HOMA-IR (SMD: −0.50, 95% CI [−0.86, −0.14], p = 0.006, I2 = 75%) and increased high-density lipoprotein cholesterol (HDL-C) levels (SMD: 0.97; 95% CI [0.26, 1.68], p = 0.007, I2 = 92%), but had no significant effect on FPG, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C). Conclusion: Current evidence supports the beneficial effects of selenium supplementation on reducing insulin levels, HOMA-IR, and increasing HDL-C levels. Selenium supplementation may be an effective strategy for reducing insulin resistance in patients with CMDs. However, more high-quality clinical studies are needed to improve the certainty of our estimates.

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“…Elevated serum levels of Se-binding protein 1, an autoantibody produced by the ovary, has been reported in women with unexplained intertility and premature ovarian failure ( 1 , 10 ). In women with gestational diabetes mellitus, serum Se levels were low, and Se supplementation improved glycemic status and lipid profiles ( 11 , 12 ).…”

Section: Selenium In the Female Reproductive Tractmentioning

confidence: 99%

Selenium supplementation and pregnancy outcomes

Dahlen

Reynolds²,

Caton³

2022

Front. Nutr.

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In vertebrates and invertebrates, selenium (Se) is an essential micronutrient, and Se deficiency or excess is associated with gonadal insufficiency and gamete dysfunction in both males and females, leading to implantation failure, altered embryonic development and, ultimately, infertility. During pregnancy, Se excess or deficiency is associated with miscarriage, pre-eclampsia (hypertension of pregnancy), gestational diabetes, fetal growth restriction and preterm birth. None of this is surprising, as Se is present in high concentrations in the ovary and testes, and work in animal models has shown that addition of Se to culture media improves embryo development and survival in vitro in association with reduced reactive oxygen species and less DNA damage. Selenium also affects uterine function and conceptus growth and gene expression, again in association with its antioxidant properties. Similarly, Se improves testicular function including sperm count, morphology and motility, and fertility. In animal models, supplementation of Se in the maternal diet during early pregnancy improves fetal substrate supply and alters fetal somatic and organ growth. Supplementation of Se throughout pregnancy in cows and sheep that are receiving an inadequate or excess dietary intake affected maternal whole-body and organ growth and vascular development, and also affected expression of angiogenic factors in maternal and fetal organs. Supplemental Se throughout pregnancy also affected placental growth, which may partly explain its effects on fetal growth and development, and also affected mammary gland development, colostrum yield and composition as well as postnatal development of the offspring. In conclusion, Se supplementation in nutritionally compromised pregnancies can potentially improve fertility and pregnancy outcomes, and thereby improve postnatal growth and development. Future research efforts should examine in more detail and more species the potential benefits of Se supplementation to reproductive processes in mammals.

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The association between serum selenium level and gestational diabetes mellitus: A systematic review and meta‐analysis

Cited by 14 publications

References 49 publications

Association between blood selenium levels and gestational diabetes mellitus: A systematic review and meta-analysis

Association between blood selenium levels and gestational diabetes mellitus: A systematic review and meta-analysis

Potential Benefits of Selenium Supplementation in Reducing Insulin Resistance in Patients with Cardiometabolic Diseases: A Systematic Review and Meta-Analysis

Selenium supplementation and pregnancy outcomes

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