The association between serum uric acid and diabetic complications in patients with type 2 diabetes mellitus by gender: a cross-sectional study

Hu, Yimeng; Qing-e, LI; Min, Rui; Deng, Yingfeng; Xu, Yancheng; Gao, Ling

doi:10.7717/peerj.10691

Cited by 30 publications

(21 citation statements)

References 49 publications

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“…The literature search identified 2613 papers, after duplication removal. After abstract evaluations, 16 studies were considered for the full text analysis [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] (Figure 1). Three studies have been excluded, since one is a duplication of previously published results [45], and two works did not report the prevalence of neuropathy in NAFLD positive and negative patients [43,44] (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis

Greco

Nascimbeni

Carubbi

et al. 2021

JCM

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Aims. The relationship between nonalcoholic fatty liver disease (NAFLD) and diabetic polyneuropathy (DPN) has been demonstrated in many studies, although results were conflicting. This meta-analysis aims to summarize available data and to estimate the DPN risk among NAFLD patients. Materials and methods. We performed a comprehensive literature review until 4 June 2021. Clinical trials analyzing the association between NAFLD and DPN were included. Results. Thirteen studies (9614 participants) were included. DPN prevalence was significantly higher in patients with NALFD, compared to patients without NAFLD (OR (95%CI) 2.48 (1.42–4.34), p = 0.001; I2 96%). This finding was confirmed in type 2 diabetes (OR (95%CI) 2.51 (1.33–4.74), p = 0.005; I2 97%), but not in type 1 diabetes (OR (95%CI) 2.44 (0.85–6.99), p = 0.100; I2 77%). Also, body mass index and diabetes duration were higher in NAFLD subjects compared to those without NAFLD (p < 0.001), considering both type 2 and type 1 diabetes. Conclusion. Despite a high heterogeneity among studies, a significantly increased DPN prevalence among type 2 diabetes subjects with NAFLD was observed. This result was not found in type 1 diabetes, probably due to the longer duration of disease. Physicians should pay more attention to the early detection of DPN, especially in patients with NAFLD.

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Section: Resultsmentioning

confidence: 99%

Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis

Greco

Nascimbeni

Carubbi

et al. 2021

JCM

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“…Serum creatinine (SCr), a biosynthetic product of phosphocreatine metabolism in muscle, is widely used in clinical practice to assess renal function and is more direct and readily available than glomerular filtration rate (GFR). Several clinical studies have shown that even within the normal range, higher SCr is strongly associated with the risk of several diseases, such as cardiovascular disease and diabetes [ 16 , 17 ]. Currently, few clinical studies have investigated the relationship between HS and SCr levels and HS-accompanied fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Wei

Wang

et al. 2022

BMC Gastroenterol

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Background Recent studies have shown that chronic kidney disease (CKD) prevalence is significantly higher in patients with hepatic steatosis (HS); however, it remains unclear whether HS is associated with serum creatinine (SCr). We aimed to explore the association between SCr levels and HS in a Chinese population. Methods We performed a cross-sectional study among 56,569 Chinese individuals. SCr level, other clinical and laboratory parameters, abdominal ultrasound and noninvasive fibrosis scores were extracted, and the fibrosis 4 score (FIB-4) was calculated. Results A total of 27.1% of the subjects had HS. After 1:1 propensity score matching (PSM) according to sex and age, we included 13,301 subjects with HS and 13,301 subjects without HS. SCr levels were significantly higher in the HS group than in the non-HS group [73.19 ± 15.14(μmoI/L) vs. 71.75 ± 17.49(μmoI/L), p < 0.001]. Univariate and multivariate regression analyses showed a positive association between SCr and the prevalence of HS. Stepwise regression analysis showed that the association between SCr and HS was independent of other metabolic syndrome components. The prevalence of HS increased significantly with increasing SCr levels. Metabolism-related indicators and liver enzymes were significantly higher in the HS group than in the non-HS group; furthermore, these parameters increased with increasing SCr levels. FIB-4 was significantly higher in the HS group than in the non-HS group but did not show an increasing trend with increasing SCr levels. Conclusions Our results showed an independent association between SCr level and HS risk in a Chinese population.

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“… 22 , 33 Other studies have reported that increased SUA is more harmful to women than to men. 34 , 36 – 38 A study of a Chinese coastal population found that each standard deviation increase in SUA was independently associated with a 1.68-µm increase in retinal venous caliber in women but not significantly in men. 39 This study noted that women's SVD measurements appeared to be more sensitive to elevated SUA levels than men's.…”

Section: Discussionmentioning

confidence: 99%

Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

Yue

Chen

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To explore the relationship between serum uric acid (SUA) and retinochoroidal microcirculation in the Chinese population. Methods This prospective cross-sectional study was conducted among the residents of Guangzhou, southern China. A commercially available optical coherence tomography angiography (OCTA) device was used to obtain the superficial vessel density (SVD) and deep vessel density in the retina and the choriocapillaris flow deficit (CFD) in the macular region. Univariable and multivariable linear regression models were used to assess the association of hyperuricemia and SUA levels with OCTA parameters. Results A total of 638 participants with normal SUA and 296 participants with hyperuricemia were included in the study. Parafoveal SVD was significantly reduced among the participants with hyperuricemia compared to participants with normal SUA ( P < 0.001), while the parafoveal CFD was higher in hyperuricemic participants than those of normal SUA levels ( P = 0.007). After adjusting for potential confounders, greater SUA levels was associated with lower SVD (β = −0.078; P < 0.001) and greater CFD (β = 0.015; P = 0.011). Gender difference analysis indicated that a 10-µmol/L increase in SUA levels among the female participants led to a 0.144 decrease in SVD ( P < 0.001), but it was not statistically significant for the male participants ( P = 0.653). Conclusions An elevated uric acid level and its fluctuations were independently associated with impaired retinal and choroidal microcirculation using OCTA in the study population. Women appear to be more sensitive to high SUA levels than men. Translational Relevance Elevating uric acid concentration may play a role in the development and progression of cardiovascular diseases through microvascular alteration, as demonstrated by OCTA parameters.

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The association between serum uric acid and diabetic complications in patients with type 2 diabetes mellitus by gender: a cross-sectional study

Cited by 30 publications

References 49 publications

Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis

Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis

Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study

Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

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