The Association between Smoking and Epiretinal Membrane

Wang, Sheng-Zhan; Tong, Qihu; Wang, Huiyun; Lü, Qianqian; Xu, Yufeng

doi:10.1038/srep38038

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…Exposure to cigarette smoke extracts had been reported to provoke activation of the TGF-β pathway and up-regulate genes related to fibrosis, that was known to play a critical role in the pathogenesis of ERMs [13,14]. However, the reported results of epidemiologic studies of the relationship between smoking and risk of ERMs were unexpectedly protective and our results had also weak tendency of decreasing odds ratio [33].…”

Section: Discussioncontrasting

confidence: 63%

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

et al. 2021

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Background The purpose of this study is to evaluate the influence of anti-vascular endothelial growth factor (VEGF) in the appearance or progression of epiretinal membranes (ERMs) in age-related macular degeneration (ARMD) and investigate confounding factors causing ERMs. Methods Seventy-six eyes that were treated for more than 36 months from the first anti-VEGF injection were assessed. Binary logistic regression analysis was performed between smoking, lens status, subretinal hemorrhage, posterior vitreous detachment (PVD) status, peripheral retinal degeneration, type of AMD, conditions of contralateral eye, and the number of injections as independent variables and appearance or progression of ERMs during 36 months as dependent variables. Results The presence of vitreomacular adhesion (VMA) or development of PVD during the observation period was significantly associated (Odds ratio [OR]: 5.77; 95% confidence interval [CI], 1.72–19.4; p = 0.005) with the appearance or progression of ERMs. Moreover, peripheral retinal degeneration was significantly associated (OR: 3.87; 95% CI, 1.15–13.0; p = 0.029). Injection number of anti-VEGF was not significantly associated (OR: 1.02; 95% CI, 0.90–1.16; p = 0.72). Conclusion This study suggests possibilities that anti-VEGF injections alone are unable to cause the development of ERMs, that VMA or developing PVD has a prior impact on the developing ERMs in ARMD similar to that of idiopathic ERMs, and that peripheral retinal degenerations and vitreomacular adhesion were both related to ERMs development and pathogenesis of ARMD.

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Section: Discussioncontrasting

confidence: 63%

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

et al. 2021

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“…Exposure to cigarette smoke extracts had been reported to provoke activation of the TGF-β pathway and up-regulate genes related to brosis, that was known to play a critical role in the pathogenesis of ERMs [10,11]. However, the reported results of epidemiologic studies of the relationship between smoking and risk of ERMs were unexpectedly protective and our results had also weak tendency of decreasing odds ratio [30].…”

Section: Discussioncontrasting

confidence: 63%

Epiretinal Membrane Appearance or Progression After Intravitreal Injection in Age-Related Macular Degeneration

Taniguchi

Yoshida

Sakamoto

et al. 2021

Preprint

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Background: To evaluate the influence of anti-vascular endothelial growth factor (VEGF) in the appearance or progression of epiretinal membranes (ERMs) in age-related macular degeneration (ARMD) and investigate determining factors.Methods: Seventy-six eyes that were treated for more than 36 months from the first anti-VEGF injection were assessed. Binary logistic regression analysis was performed between smoking, lens status, subretinal hemorrhage, posterior vitreous detachment (PVD) status, peripheral degeneration, contralateral eye, and the number of injections as independent variables and appearance or progression of ERMs during 36 months as dependent variables.Results: The presence of vitreous macular adhesion (VMA) or development of PVD during the observation period was significantly associated (Odds ratio [OR]: 5.76; 95% confidence limit [CL], 1.72-19.3; p＝0.005) with the appearance or progression of ERMs. Moreover, peripheral retinal degeneration was significantly associated (OR: 3.85; 95% CL, 1.15-13.0; p＝0.029). Injection number of anti-VEGF was not significantly associated (OR: 1.02; 95% CL, 0.90-1.16; p＝0.73). Number of anti-VEGF injections in ARMD had little relationship with developing secondary ERMs. VMA or developing PVD and peripheral degenerations had an association with developing ERMs. Conclusion: This study suggests possibilities that anti-VEGF injections alone are unable to cause the development of ERMs, that the vitreoretinal interface has a prior impact on the developing ERMs in ARMD similar to that of idiopathic ERMs, and that peripheral degenerations co-exist with or are evoked by vitreoretinal adhesion in the pathogenesis of ARMD, both being related to ERMs development.

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“…Potential risk factors were selected based on a literature search or those related to putative mechanisms proposed by the study team, they included age, sex, 7 body mass index (BMI; kg/m 2 )), smoking, 19 hypertension, spherical equivalent, 20 visual acuity, 21 plasma high-density lipoprotein (HDL)-cholesterol, triglycerides, HbA1c 22 and cataract. 11 HbA1c, triglycerides and HDL were measured on blood samples collected at the health assessment.…”

Section: Covariate Selection and Categorisationmentioning

confidence: 99%

Assessment of the Vitreomacular Interface Using High-Resolution OCT in a Population-Based Cohort Study of Older Adults

Quinn

Steel

Chakravarthy

et al. 2020

Ophthalmology Retina

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Belfast provide core financial support for the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). Macular Society, College of Optometrists and Diabetes UK funded individual researchers. The sponsors and funding organisations had no role in the design or conduct of this research. No conflicting relationship exists for any author Running head: Vitreomacular interface features in NICOLA vitreomacular adhesion (VMA), vitreomacular interface (VMI), Vitreomacular traction (VMT), full thickness macular hole (FTMH), lamellar macular hole (LMH), age-related macular degeneration (AMD), epiretinal membrane (ERM), optical coherent tomography (OCT), the International Vitreomacular Traction Study (IVTS), spectral domain OCT (SD-OCT), Northern Ireland Cohort Study for the Longitudinal Study of Ageing (NICOLA), computer 32 assisted home interview (CAPI), self-completion questionnaires (SCQ), Northern Ireland 33 Clinical Research Facility (NICRF), Early Treatment Diabetic Retinopathy (ETDRS), Colour fundus photography (CFP), multicolour (MC), Network of Ophthalmic Reading Centres UK (NetWORC UK), psuedo macular hole (PMH), macular hole (MH), body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), Choroidal neovascularisation (CNV), geographic atrophy (GA), high-density lipoprotein cholesterol (HDL), confidence intervals (CI), odds ratios (OR).

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The Association between Smoking and Epiretinal Membrane

Cited by 5 publications

References 44 publications

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Epiretinal Membrane Appearance or Progression After Intravitreal Injection in Age-Related Macular Degeneration

Assessment of the Vitreomacular Interface Using High-Resolution OCT in a Population-Based Cohort Study of Older Adults

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