The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population

Wuopio, Jonas; Lin, Yi Ting; Orho‐Melander, Marju; Engström, Gunnar; Ärnlöv, Johan

doi:10.1093/ehjopen/oead024

Cited by 9 publications

(2 citation statements)

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“…IHD is most commonly caused by atherosclerosis ( 24 , 25 ). A Swedish cohort study found a correlation between a higher estimated 24-h sodium excretion and coronary atherosclerosis ( 26 ). This finding provides additional support for the conclusions drawn in our study.…”

Section: Discussionmentioning

confidence: 99%

Sodium intake and the risk of various types of cardiovascular diseases: a Mendelian randomization study

Fu,

Chen,

Ding

et al. 2023

Front. Nutr.

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BackgroundThe existing literature on the link between sodium intake and cardiovascular disease (CVD) largely consists of observational studies that have yielded inconsistent conclusions. In this study, our objective is to assess the causal relationship between sodium intake and 50 CVDs using two-sample Mendelian randomization (MR) analysis.MethodsMR analyses were performed to investigate the associations between urinary sodium/creatinine ratio (UNa/UCr), an indicator of sodium intake, and 50 CVDs. The genome-wide association study (GWAS) for UNa/UCr was from the UK Biobank (UKBB), and the GWASs for CVDs were from FinnGen. A false discovery rate (FDR) threshold of 5% was applied for multiple comparison correction.ResultsThe inverse-variance weighted method indicated that the genetically predicted UNa/UCr was significantly associated with 7 of 50 CVDs, including “Coronary atherosclerosis” (OR = 2.01; 95% CI: 1.37, 2.95), “Diseases of arteries, arterioles and capillaries” (OR = 1.88; 95% CI: 1.20, 2.94), “Hard cardiovascular diseases” (OR = 1.71; 95% CI: 1.24, 2.35), “Ischemic heart diseases” (OR = 2.06; 95% CI: 1.46, 2.93), “Major coronary heart disease event” (OR = 1.99; 95% CI: 1.36, 2.91), “Myocardial infarction” (OR = 2.03; 95% CI: 1.29, 3.19), and “Peripheral artery disease” (OR = 2.50; 95% CI: 1.35, 4.63). Similar results were obtained with the MR-Egger and weighted median methods. No significant heterogeneity or horizontal pleiotropy was found in this analysis.ConclusionOur study has uncovered a significant positive causal relationship between UNa/UCr and various CVDs. These results offer a new theoretical foundation for advocating the restriction of sodium intake as a preventive measure against CVD.

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Section: Discussionmentioning

confidence: 99%

Sodium intake and the risk of various types of cardiovascular diseases: a Mendelian randomization study

Fu,

Chen,

Ding

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“… 7 As an example, MR analysis supported that short sleep duration increases peripheral artery disease. 8 The common paths of Vascular Medicine and Coronary Artery Disease were illustrated in EHJ Open by carotid and coronary atherosclerosis being associated with an estimated 24 h sodium excretion, 9 for which the underlying mechanisms remain to be fully explored. 10 …”

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confidence: 99%