The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China

Zhao, Miaomiao; Ren, Longbing; Zhou, Zhitong; Wang, Tao; Li, Jue

doi:10.2147/clep.s360395

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…In a study by Prichard et al ., 20–40% of CAPD patients had elevated levels of total cholesterol and LDL. [ 28 ] Sevinc et al . suggested a positive linear relation between CIMT and synergistic effect of the traditional factors of atherosclerosis, and they are responsible for 32.8% increase in the carotid artery IMT.…”

Section: Discussionmentioning

confidence: 99%

The Role of Dyslipidemia in Atherogenesis in Peritoneal Dialysis Patients

Rebić¹,

Begić

Aziri

et al. 2023

Advanced Biomedical Research

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Background: To evaluate atherosclerotic changes in carotid arteries (CCA) in uremic patients before and after 18 months of continuous ambulatory peritoneal dialysis (CAPD) treatment, and to evaluate the impact of dyslipidemia and CAPD treatment on vascular remodeling. Materials and Methods: We conducted a longitudinal, prospective study during 2020 and 2021 at the Clinic for Nephrology, Clinical Center University of Sarajevo. Patients with end-stage renal disease were included and were followed during 18 months of CAPD treatment. All patients were treated using commercially prepared biocompatible balanced dialysis solutions. Carotid intima-media thickness (IMT) and atherosclerotic plaques on the common carotid artery (CCA) were measured by echotomography. Results: A total of 50 patients were included and were followed during 18 months of CAPD treatment. Lipid values in the serum of patients with CAPD were significantly lower after 18 months of CAPD treatment compared to the values before treatment, while the value of high-density lipoprotein (HDL) was significantly increased after 18 months of CAPD treatment. The values of IMT and the diameter of the CCA compared to the basal values were significantly lower ( P < 0.001). Conclusion: We demonstrated significantly lower lipid values and higher HDL levels following CAPD treatment. Correct selection of the targeted pharmacological intervention can substantially impact the regression of vascular changes in patients on peritoneal dialysis.

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Section: Discussionmentioning

confidence: 99%

The Role of Dyslipidemia in Atherogenesis in Peritoneal Dialysis Patients

Rebić¹,

Begić

Aziri

et al. 2023

Advanced Biomedical Research

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“…This leads to increased P53 protein synthesis and apoptosis (22). Actin disruption could activate DNase, which is known to split DNA and induce apoptosis of proximal tubular cells (23). Several investigations demonstrate that statin-induced apoptosis is potentially prompted by isoprenoid depletion, which results in elevated levels of cytosolic calcium and activation of mitochondrialmediated apoptotic signaling (18).…”

Section: Apoptosismentioning

confidence: 99%

A mini-review to the common adverse-effects of statins

Nasri¹

2022

J Ren Endocrinol

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Effects of statins on kidney function in older adults

Fravel,

Ernst,

Woods

et al. 2024

J American Geriatrics Society

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BackgroundThe effect of statin therapy on kidney function among older adults is unclear.ObjectivesTo examine the association between statin use and changes in estimated glomerular filtration rate (eGFR) and urine albumin‐to‐creatinine ratio (UACR), positive or negative, in an older adult cohort with versus without chronic kidney disease (CKD) at baseline.MethodsThis analysis included 18,056 participants aged ≥65 years with versus without CKD at baseline in a randomized trial of low‐dose aspirin, who had no prior cardiovascular events, major physical disability, or dementia initially. Outcome measures included eGFR and UACR. Linear mixed‐effects models were used to estimate the associations of baseline statin use versus no use with eGFR and UACR changes over time. The inverse‐probability of treatment‐weighting technique was used for all analyses to address confounding by indication due to the lack of randomization in treatment assignment.ResultsStatin use was not associated with change in eGFR, UACR, or incident CKD in participants with or without CKD at baseline (p > 0.05 for all associations). Subgroup analyses found no significant interactions between statin and age, sex, diabetes, country, and frailty status on any of the study outcomes.ConclusionsAmong adults ≥65 years of age, with and without CKD, statin therapy was not associated with improved or worsened kidney function. This data suggests that the decision to use versus not use statins in this population may be ideally guided by factors other than kidney health.

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The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China

Cited by 3 publications

References 51 publications

The Role of Dyslipidemia in Atherogenesis in Peritoneal Dialysis Patients

The Role of Dyslipidemia in Atherogenesis in Peritoneal Dialysis Patients

A mini-review to the common adverse-effects of statins

Effects of statins on kidney function in older adults

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