2024
DOI: 10.21203/rs.3.rs-3928046/v1
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The association between testosterone, estradiol, estrogen sulfotransferase and idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study

Qingying Xu,
Guangwang Hu,
Qunying Lin
et al.

Abstract: Background The causal relationships between testosterone, estradiol, estrogen sulfotransferase, and idiopathic pulmonary fibrosis (IPF) are not well understood. This study employs a bidirectional two-sample Mendelian Randomization (MR) approach to explore these associations. Methods We extracted significant genetic loci associated with testosterone, estradiol, and estrogen sulfotransferase from GWAS summary data as instrumental variables, with IPF as the outcome variable for a two-sample Mendelian randomizat… Show more

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