The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Gallegos‐Arreola, Martha Patricia; Figuera, Luis E.; Ramos-Silva, Adriana; Salas-González, Efraín; Puebla-Pérez, Ana Marı́a; Peralta-Leal, Valeria; Garcı́a-Ortiz, José Elı́as; Dávalos-Rodríguez, Ingrid Patricia; Zúñiga‐González, Guillermo Moisés

doi:10.5114/aoms.2014.47830

Cited by 28 publications

(30 citation statements)

References 57 publications

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“…In Mexico, BC represents one of the leading causes of death in working-age women (Chávarri-Guerra et al 2012;Miller et al, 2012;Gómez Flores et al, 2013;Ramírez-Patiño et al, 2013;Gallegos-Arreola et al, 2014). These facts are consistent with the observations made in the current study, where the average age of patients with BC was 54.17 (± 11.6) years.…”

Section: Discussionsupporting

confidence: 82%

“…All patients were also interviewed to determine their occupational exposure and as well as use of pharmacological therapies. The BC patient database and the DNA samples have been examined for other polymorphisms (Gómez Flores-Ramos et al, 2013;Ramírez-Patiño et al, 2013;Gallegos et al, 2014).…”

Section: Sample Collection and Patient Informationmentioning

confidence: 99%

“…The state of Jalisco exhibits one of the highest mortalities associated with BC, and only 10% of all cases of BC are detected early at stage I (Gómez Flores-Ramos et al, 2013;Ramírez-Patiño et al, 2013;Gallegos-Arreola et al, 2014). BC is considered to be a multifactorial disease and might result from a combination of abnormal gene interactions and environmental factors (Gómez Flores-Ramos et al, 2013;Gallegos-Arreola et al, 2014). Therefore, elucidating genetic variants among different ethnic groups could contribute to an explanation for the differences in the progression of cancer as well as in chemotherapeutic response between these groups.…”

Section: Introductionmentioning

confidence: 99%

“…In many countries, particularly in Mexico, the incidence of BC has increased in the last seven years, such that BC is now one of the main causes of death in working-age women (Chávarri-Guerra et al, 2012). The state of Jalisco exhibits one of the highest mortalities associated with BC, and only 10% of all cases of BC are detected early at stage I (Gómez Flores-Ramos et al, 2013;Ramírez-Patiño et al, 2013;Gallegos-Arreola et al, 2014). BC is considered to be a multifactorial disease and might result from a combination of abnormal gene interactions and environmental factors (Gómez Flores-Ramos et al, 2013;Gallegos-Arreola et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

Soto-Quintana¹,

Zúñiga‐González²,

Ramírez-Patiño³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in 13067 GSTM1 polymorphism in breast cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13066-13075 (2015) the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with those of 558 Mexican women with breast cancer (BC). The genotype frequencies observed in the controls and patients with BC were 38 and 45% for the null GSTM1 genotype, respectively. The obtained odds ratio (OR) was 1.36, with a 95% confidence interval (95%CI) of 1.02-1.8, P = 0.04. The protective association was also evident upon analysis of the distributions of the null GSTM1 genotype in patients with positive chemotherapy response who had high plasma levels of glucose (OR 0.56, 95%CI = 0.33-0.94, P = 0.03). This study suggested that the null GSTM1 genotype is associated with BC susceptibility in the Mexican population analyzed.

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Section: Discussionsupporting

confidence: 82%

Section: Sample Collection and Patient Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

Soto-Quintana¹,

Zúñiga‐González²,

Ramírez-Patiño³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Recently, Zhang et al observed an association between the CBS rs706209 polymorphism and clear cell renal cell carcinoma risk in the Chinese population35. Soon afterwards, Gallegos-Arreola and colleagues reported that the 844ins68 polymorphism in the CBS gene contributes significantly to breast cancer susceptibility in Mexican population36. Nevertheless, negative results have been observed with regard to different types of cancer373839.…”

Section: Discussionmentioning

confidence: 99%

Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population

Zhou

Zhang

et al. 2016

Sci Rep

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Aberrant DNA methylation has been implicated in prostate carcinogenesis. The one-carbon metabolism pathway and related metabolites determine cellular DNA methylation and thus is thought to play a pivotal role in PCa occurrence. This study aimed to investigate the contribution of genetic variants in one-carbon metabolism genes to prostate cancer (PCa) risk and the underlying biological mechanisms. In this hospital-based case-control study of 1817 PCa cases and 2026 cancer-free controls, we genotyped six polymorphisms in three one-carbon metabolism genes and assessed their association with the risk of PCa. We found two noncoding MTR variants, rs28372871 T > G and rs1131450 G > A, were independently associated with a significantly increased risk of PCa. The rs28372871 GG genotype (adjusted OR = 1.40, P = 0.004) and rs1131450 AA genotype (adjusted OR = 1.64, P = 0.007) exhibited 1.40-fold and 1.64-fold higher risk of PCa, respectively, compared with their respective homozygous wild-type genotypes. Further functional analyses revealed these two variants contribute to reducing MTR expression, elevating homocysteine and SAH levels, reducing methionine and SAM levels, increasing SAH/SAM ratio, and promoting the invasion of PCa cells in vitro. Collectively, our data suggest regulatory variants of the MTR gene significantly increase the PCa risk via decreasing methylation potential. These findings provide a novel molecular mechanism for the prostate carcinogenesis.

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Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

Rajendran

Shen

Glawe

et al. 2019

Comprehensive Physiology

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Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of molecular and cellular physiological responses leading to vascular remodeling of the macro- and microcirculation. Although cellular mechanisms of vascular remodeling such as arteriogenesis and angiogenesis have been studied, therapeutic approaches in these areas have had limited success due to the complexity and heterogeneous constellation of molecular signaling events regulating these processes. Understanding central molecular players of vascular remodeling should lead to a deeper understanding of this response and aid in the development of novel therapeutic strategies. Hydrogen sulfide (H2S) and nitric oxide (NO) are gaseous signaling molecules that are critically involved in regulating fundamental biochemical and molecular responses necessary for vascular growth and remodeling. This review examines how NO and H2S regulate pathophysiological mechanisms of angiogenesis and arteriogenesis, along with important chemical and experimental considerations revealed thus far. The importance of NO and H2S bioavailability, their synthesis enzymes and cofactors, and genetic variations associated with cardiovascular risk factors suggest that they serve as pivotal regulators of vascular remodeling responses.

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The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Cited by 28 publications

References 57 publications

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

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