The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people

Wang, Panpan; Lei, Jianqin; Wang, Yuan; Wang, Hongli; Sun, Liang; Hu, Bing; Wang, Sufang; Zhang, Dongmei; Chen, Guimei; Liang, Chunmei; Tao, Fangbiao; Yang, Linsheng; Wu, Q B

doi:10.1016/j.ecoenv.2023.115289

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…Furthermore, a higher cobalt content has been observed in whole blood samples of the diabetic population ( 41 ). Coincidentally, cobalt is significantly associated with a reduction in fasting plasma glucose levels in elderly individuals and women without hyperlipidemia ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Huang,

Zheng,

Wang

et al. 2024

Front. Nutr.

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IntroductionSpontaneous preterm birth (SPB) is a significant cause of neonatal mortality, yet its etiology remains unclear. Cobalt, an essential trace element, might be a risk factor for SPB. This study aims to investigate the relationship between maternal serum cobalt concentration and SPB, and to clarify the role of blood lipids and fasting blood glucose (FBG) in this relationship.MethodsWe conducted a nested case-control study within the Beijing Birth Cohort Study. Serum samples were obtained from 222 pregnant women with SPB and 224 controls during the first (7–13 weeks of pregnancy) and third trimesters (32–42 weeks of pregnancy). Serum cobalt concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Fasting blood glucose and lipids levels were detected using a fully automated biochemical immunoassay instrument. Logistic regression models and linear regression models were established to explore the association between serum cobalt concentration and the risk of SPB in pregnant women, and to test the mediating effect of fasting blood glucose (FBG) and lipids.ResultsWe found that the serum cobalt concentration in mothers with SPB and controls was similar in the first trimester, with values of 0.79 (0.58–1.10) ng/mL and 0.75 (0.51–1.07) ng/mL, respectively. However, in the third trimester, the cobalt concentration increased to 0.88 (0.59–1.14) ng/mL and 0.84 (0.52–1.19) ng/mL, respectively. In the logistic regression model, when considering the third trimester of pregnancy, after adjusting for ethnicity, pre-pregnancy body mass index (BMI), maternal age, education, income, and parity, it was observed that the medium level of cobalt concentration (0.63–1.07 ng/ml) had a negative correlation with the risk of SPB. The odds ratio (OR) was 0.56, with a 95% confidence interval of 0.34–0.90 ng/mL and a p-value of 0.02. This suggests that cobalt in this concentration range played a protective role against SPB. Additionally, it was found that FBG in the third trimester of pregnancy had a partial intermediary role, accounting for 9.12% of the association. However, no relationship between cobalt and SPB risk was found in the first trimester.ConclusionDuring the third trimester, intermediate levels of maternal cobalt appear to offer protection against SPB, with FBG playing a partial mediating role. To further clarify the optimal cobalt concentrations during pregnancy for different populations, a multi-center study with a larger sample size is necessary. Additionally, exploring the specific mechanism of FBG’s mediating role could provide valuable insights for improving the prevention of SPB.

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Section: Discussionmentioning

confidence: 99%

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Huang,

Zheng,

Wang

et al. 2024

Front. Nutr.

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“…Emphasize the importance of addressing osteosarcopenia in the elderly population to improve their well-being (Vahdani et al, 2023). Epidemiological studies about the effect of essential metal mixtures on fasting plasma glucose levels among older adults are sparse (Wang et al, 2023). Smoking describes overt behavior were smokers inhale tobacco.…”

Section: Introductionmentioning

confidence: 99%

Physical activity as an effort to prevent hypertension in the elderly

A. Sasarari,

Sumarmi,

Tri Wijayanti

et al. 2024

Junedik

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Introduction hypertension is one of the common health problems in the elderly population and can increase the risk of cardiovascular disease and other complications. Physical activity has been shown to be effective in preventing and managing hypertension in the elderly. Objective identify and evaluate different types of physical activity that can help in the prevention of hypertension in the elderly. Methods type of quantitative research with a case control approach. The total population is 42 respondents. Data collection using questionnaires. Data analysis using Chi-square test. Results that physical activity can prevent hypertension in the elderly chi-Square test results with p value: 0.634. which means that physical activity is not a risk factor for causing hypertension. Conclusion regular and diverse physical activity is an important strategy in the prevention of hypertension in the elderly. Physical activity programs tailored to individual needs and abilities should be encouraged and widely implemented in an effort to maintain heart health and reduce the risk of hypertension in the elderly population. Further efforts are needed to increase public awareness of the importance of physical activity in maintaining heart health and preventing cardiovascular disease in the elderly

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Physical activity modified association of urinary metals mixture and fasting blood glucose in children: From two panel studies

Liu,

Guo,

et al. 2024

Environmental Research

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The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people

Cited by 4 publications

References 53 publications

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Maternal cobalt concentration and risk of spontaneous preterm birth: the role of fasting blood glucose and lipid profiles

Physical activity as an effort to prevent hypertension in the elderly

Physical activity modified association of urinary metals mixture and fasting blood glucose in children: From two panel studies

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