The association between the Lie scale of the Maudsley personality inventory and striatal dopamine D₂/D₃ receptor availability of healthy Chinese community subjects

Abstract

The present study examined the relationship between the Lie scale scores and striatal D(2)/D(3) receptor availability with respect to the cerebellum in 42 healthy community volunteers in Taiwan using single photon emission computed tomography (SPECT) with [(123)I]iodo-benzoaminde (IBZM). Even after controlling of age and educational level, subjects' Lie scale scores of the Maudsley personality inventory correlate negatively with D(2)/D(3) receptor availability. Individual with higher Lie scale scores may have higher impulsivity due to lower dopaminergic availability.

Truth, lies or self-deception? Striatal D2/3 receptor availability predicts individual differences in social conformity

“…Our finding of a negative association between [ 11 C]raclopride BP ND and Lie score is entirely consistent with previous research, both in terms of the direction of the association (Cervenka et al, 2010;Huang et al, 2006;Reeves et al, 2007) and its localization to the sensorimotor striatum (dorsal putamen) (Reeves et al, 2007), and therefore confirms this relationship in a fifth independent sample of volunteers. The present study additionally extends this finding in showing that IM scores correlate positively with Lie scores, and negatively with [ 11 C]raclopride BP ND in the sensorimotor striatum.…”

“…Additionally, whilst social desirability scores show strong test-retest reliability over a period of around 1-2 months (Crowne and Marlowe, 1960;Eysenck and Eysenck, 1991;Knowles and Kreitman, 1965;Paulhus, 1991;Sackeim and Gur, 1978), we are not aware of data on the reliability of social desirability scores over longer time periods. A further limitation is that, in contrast to previous studies (Cervenka et al, 2010;Huang et al, 2006;Reeves et al, 2007), we did not correct for educational level in this sample, as this data was not available in all subjects. In addition, although no significant influence of study design was detected, the PET protocols from the three studies from which personality data were collected did vary and may potentially confounded results.…”

“…In a secondary analysis, for completeness, we also explored relationships between [ 11 C]raclopride BP ND and socially desirable responding in the associative and limbic striatum. Finally, because previous studies have reported associations between striatal D 2/3 receptor measures and the personality traits of neuroticism (Huang et al, 2006), extraversion (Kim et al, 2009) and psychoticism (Gray et al, 1994), the relationship between [ 11 C]raclopride BP ND and these traits (indexed by the EPQ-R) was also investigated. All correlations were two-tailed.…”

“…The combined use of positron emission tomography (PET) and data obtained through self-report questionnaires has linked individual variation in striatal D 2/3 dopamine receptor availability to specific personality traits, including psychoticism or 'tough-mindedness' (Gray et al, 1994), social detachment (aloofness) (Breier et al, 1998;Farde et al, 1997), neuroticism (Huang et al, 2006) and extraversion (Kim et al, 2009).…”

“…The first study to investigate the relationship between striatal D 2/3 receptor availability and SDR reported a significant negative association between Lie Scale score-a measure of SDR that forms part of the Maudsley Personality Inventory (MPI) (Eysenck and Eysenck, 1975)-and striatal D 2/3 receptor availability, as indexed by the single photon emission tomography (SPET) radiotracer [ 123 I]iodo-benzoamide (IBZM) (Huang et al, 2006). This finding has since been replicated in both older women and young adults, using the Lie Scale from the Eysenck Personality Questionnaire (EPQ) (Eysenck and Eysenck, 1975) and the PET D 2/3 receptor radiotracer [ 11 C]raclopride (Reeves et al, 2007); and in middle-aged adults using Swedish universities Scales of Personality (SSP) (Gusustavsson et al, 2000) and [ 11 C]raclopride (Cervenka et al, 2010).…”