The association between thyroid autoantibodies in serum and abnormal function and structure of the thyroid

Yan, Yuerong; Gao, Xi-Lian; Zeng, Jing; Liu, Yang; Lv, Qingguo; Jiang, Jing; Huang, Hui; Tong, Nanwei

doi:10.1177/0300060514562487

Cited by 19 publications

(26 citation statements)

References 44 publications

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“…Consistent with previous researches [11, 17, 36], the positive thyroid autoantibodies show substantial correlation with female gender and developing of almost all thyroid dysfunction types in the present report. TPOAb was identified as a major autoantigen.…”

Section: Discussionsupporting

confidence: 93%

“…However, few long-term follow-up studies, 13-year follow-up in Australia [35] and 20-year follow-up in the UK [8], have associated the increased level of thyroid antibodies (TPOAb or TgAb) to raised risk of hypothyroidism and increased levels of serum TSH [8, 35]. The positive rate for TPOAb and/or TgAb is shown to be 13.8% in euthyroid population in China [17], while this rate is much higher in our study (27%). This could be attributed to higher incidence rate of hyperthyroidism in our population than other countries.…”

Section: Discussionmentioning

confidence: 99%

“…It is worth noting that thyroid autoantibodies, including TPOAb and thyroid globulin antibody (TgAb), may present in a disease-free population [11]. However, the prevalence of positive thyroid autoantibodies was significantly higher in thyroid dysfunction than in euthyroid subjects [17]. In addition, the level of thyroid autoantibodies varies between populations and may be influenced by heredity, environment, and other factors including birth weight, iodine excess and deficiency, parity, oral contraceptive use, reproductive span, stress, seasonal variation, allergy, smoking, radiation damage to the thyroid gland, viral and bacterial infections [18, 19].…”

Section: Introductionmentioning

confidence: 99%

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Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

et al. 2017

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BackgroundThe prevalence of thyroid dysfunction is high in Isfahan, an area of iodine sufficient in Iran. The aim of this study is to investigate the incidence of thyroid dysfunctions in adults of metropolitan Isfahan and to determine the role of thyroid autoantibodies.MethodsIn a population-based cohort study in 2006–2011, we measured TSH, T4, T3, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in 618 out of 2254 people who were euthyroid in 2006. The incidence rates per 1000 person-year (pr) were calculated. The odds ratio (OR), relative risk (RR), and 95% confidence interval (95% CI) were calculated based on logistic regression to quantify the potential predictors of thyroid dysfunction. The receiver-operator characteristic (ROC) analysis along with area under the curve (AUC) was used to determine the optimal cutoff values for baseline TPOAb and TgAb as predictors of thyroid dysfunction.ResultsWithin a 6-year follow-up, the incidence rate of hypothyroidism was 3.3 in women and 2.1 in men while the incidence rate of hyperthyroidism was 3.8 in women and none in men per 1000 (person-year). A cutoff value of TPOAb at 38 IU/mL was obtained to differentiate the patients with hypothyroidism and hyperthyroidism, with specificity of 0.75 and sensitivity of 0.76, and AUC (CI 95%) of 0.882 (0.743–1.02), P = 0.01 and 0.817 (0.600–1.035) P = 0.033, respectively. There is a statistically significant association of hypothyroidism and hyperthyroidism with positive TPOAb [RR (CI 95%): 1.99 (1.27–3.13) and 2.20 (1.23–3.95), respectively].ConclusionsThe incidence rate of thyroid dysfunction is high in Isfahan, and higher TPOAb concentration is its strong predictor.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

et al. 2017

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“…The influence of gender demonstrated in this study was consistent with previous reports. 1,7,8,[10][11][12][13] Age did not influence the rate of positive thyroid antibodies. This was contrary to other reports.…”

Section: Predictors For Positive Anti-tpomentioning

confidence: 82%

High Prevalence of Thyroid Antibodies in Urban Population of Peninsular Malaysia

Ma¹,

Omar²,

Sukor³

et al. 2020

imjm

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INTRODUCTION: Thyroid antibodies are closely related to autoimmune thyroid disorders. To date, there are no data on the prevalence of these antibodies among the Malaysian population. This study aimed to determine the prevalence of thyroid antibodies; and the factors associated with thyroid antibodies in the Malaysian adult population. MATERIALS AND METHODS: A cross-sectional study was performed in 5 preassigned regions in Peninsular Malaysia. Participants’ sociodemographic profile and medical history were recorded. Physical examinations were done looking for abnormalities of the thyroid gland and signs of thyroid dysfunctions. Fifteen mils of blood were withdrawn and analysed for thyroid function, anti-thyroperoxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies at a central laboratory. RESULTS: Among the total of 2190 respondents, the overall prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; mainly found in urban and coastal areas. Only 7% to 9% of those with positive anti-TPO or antiTG antibodies had either hypo- or hyperthyroidism. The predictors for positive anti-TPO antibody were female [adjusted OR 1.7 (95%CI: 1.2–2.4); p=0.001], Indian [adjusted OR 1.9 (95%CI: 1.1–3.1); p=0.020], and having a goitre [adjusted OR 1.8 (95%CI: 1.2–2.8), p=0.004]. The predictors of positive anti-TG antibody was female [adjusted OR 2.3 (95%CI: 1.6–3.3); p<0.001], and having a goitre [adjusted OR 2.0 (95%CI: 1.3–3.4), p=0.001]. Those living in rural areas had 38% lower risk of having positive anti-TG. CONCLUSIONS: The prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; were higher among the urban and coastal populations. Those living in rural areas had lower risks of anti-TG antibody.

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“…High concentrations of TgAb and TPOAb can also be detected in other thyroid diseases, such as Graves' disease and primary hypothyroidism ( 70 , 71 ). Moreover, thyroid autoantibodies are present in a disease-free population ( 72 ). Hence, identification of novel biomarkers for HT is important.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA expression profiles identify lncRNA‑XLOC_I2_006631 as a potential novel blood biomarker for Hashimoto's thyroiditis

et al. 2020

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Long non-coding RNAs (lncRNAs) have been increasingly recognized as important immune checkpoints involved in the pathogenesis of autoimmune diseases. However, the exact role of lncRNAs in Hashimoto's thyroiditis (HT) has been rarely studied. The aim of the present study was to investigate the role of lncRNAs and the potential biomarkers in HT, a total of 33 patients with HT and 32 healthy volunteers were enrolled in the present study, and five patients and five healthy controls were investigated using next generation sequencing. A total of 218 dysregulated lncRNAs, including 94 upregulated and 124 downregulated lncRNAs, were identified and examined in the peripheral blood mononuclear cells (PBMCs) from patients with HT. The majority of the lncRNAs were intergenic and exonic (66.06%). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that abnormally expressed lncRNAs were enriched in the 'NF-kB expression', in the 'TGF-β signaling pathway' and in the 'JAK-STAT signaling pathway', which are associated with the immunopathogenic mechanisms of HT. In total, three lncRNAs (LOC729737, XLOC_I2_006631 and BC041964) were validated and had a trend identical to that detected by the sequencing results. The expression of lncRNA-XLOC_I2_006631 was upregulated and was positively correlated with the serum concentrations of anti-thyroperoxidase antibody in patients with HT. Methyl-CpG-binding protein 2 (MECP2) was identified as the potential regulatory gene of lncRNA-XLOC_I2_006631 using a prediction program. The expression of MECP2 was increased and was positively correlated with the elevated expression levels of lncRNA-XLOC_I2_006631 and anti-thyroperoxidase antibody in patients with HT. Furthermore, lncRNA-XLOC_I2_006631 was able to regulate MECP2 expression in vitro . Receiver operating characteristic curve analysis suggested that lncRNA-XLOC_I2_006631 has a potential diagnostic value. Collectively, the present results indicated the important role of dysregulated lncRNAs in HT and demonstrated that lncRNA-XLOC_I2_006631 functioned as a positive regulator of MECP2 expression, suggesting a potential mechanism. Thus, lncRNA-XLOC_I2_006631 may be used as a biomarker of HT.

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The association between thyroid autoantibodies in serum and abnormal function and structure of the thyroid

Cited by 19 publications

References 44 publications

Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

Incidence of thyroid dysfunction in an Iranian adult population: the predictor role of thyroid autoantibodies: results from a prospective population-based cohort study

High Prevalence of Thyroid Antibodies in Urban Population of Peninsular Malaysia

Long non‑coding RNA expression profiles identify lncRNA‑XLOC_I2_006631 as a potential novel blood biomarker for Hashimoto's thyroiditis

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