The association between vitamin D status and tuberculosis in children

Gou, Xiaoyun; Pan, Lingli; Tang, Fajuan; Hu, Gao; Xiao, Dongqiong

doi:10.1097/md.0000000000012179

Cited by 56 publications

(37 citation statements)

References 36 publications

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“…Whilst IFN-γ is a key element in the containment of Mtb within the MΦ, it is now widely recognized that performing this function requires the presence of vitamin D (63). Thanks to vitamin D, the macrophage increases phagosome maturation and the production of antimicrobial peptides through the maximal regulation of the hCAP-18 gene encoding for cathelicidin antimicrobial peptide which activates, in turn, the transcription of autophagy-related genes (20).…”

Section: Innate Immune Response Against Mycobacterium Tuberculosismentioning

confidence: 99%

Immune Response to Mycobacterium tuberculosis: A Narrative Review

et al. 2019

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The encounter between Mycobacterium tuberculosis (Mtb) and the host leads to a complex and multifaceted immune response possibly resulting in latent infection, tubercular disease or to the complete clearance of the pathogen. Macrophages and CD4 + T lymphocytes, together with granuloma formation, are traditionally considered the pillars of immune defense against Mtb and their role stands out clearly. However, there is no component of the immune system that does not take part in the response to this pathogen. On the other side, Mtb displays a complex artillery of immune-escaping mechanisms capable of responding in an equally varied manner. In addition, the role of each cellular line has become discussed and uncertain further than ever before. Each defense mechanism is based on a subtle balance that, if altered, can lean to one side to favor Mtb proliferation, resulting in disease progression and on the other to the host tissue damage by the immune system itself. Through a brief and complete overview of the role of each cell type involved in the Mtb response, we aimed to highlight the main literature reviews and the most relevant studies in order to facilitate the approach to such a complex and changeable topic. In conclusion, this narrative mini-review summarizes the various immunologic mechanisms which modulate the individual ability to fight Mtb infection taking in account the major host and pathogen determinants in the susceptibility to tuberculosis.

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Section: Innate Immune Response Against Mycobacterium Tuberculosismentioning

confidence: 99%

Immune Response to Mycobacterium tuberculosis: A Narrative Review

et al. 2019

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“…17,18 Vitamin D deficiency has been associated with increased incidence of infectious disease, especially respiratory tract diseases, and infection-associated mortality in the general population. 19,20…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D3 deficiency among cases with extensive tinea corporis infection

Raja¹,

Hameed²

2020

Int J Res Dermatol

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Background: Abnormal serum vitamin D3 levels have been implicated as risk factors for development of various skin disorders. Hence this study was planned to assess the prevalence of vitamin D3 deficiency among patients with Tinea corporis who were attending outpatient department of dermatology in a tertiary care centre.Methods: The cross sectional study was conducted by the department of dermatology, venereology and leprosy, at Sri Muthukumaran Medical College Hospital and Research Institute, among the patients attending the outpatient department, during the month of June to August 2019. A total of fifty cases with extensive Tinea corporis infection were included in the study. The study was conducted using a proforma with the detailed clinical history and also patients underwent skin scrapping for KOH mount and serum vitamin D3 analysis. Data was entered in Microsoft excel and data analysis was done using Statistical Package for Social Sciences (SPSS) version 17.Results: Among the cases with extensive Tinea corporis infection, only 20% of cases were found to have normal levels of serum vitamin D3 whereas 48.3% of cases were found to have serum vitamin D3 insufficiency and 31.7% of cases had deficiency of serum vitamin D3Conclusions: Screening for vitamin D3 deficiency for all cases with extensive Tinea corporis infection can be recommended. Further large scale clinical trials are needed to assess whether vitamin D3 deficiency has any role to play in pathogenesis and treatment of extensive Tinea corporis infection.

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“…Vitamin D3 is mainly produced in the skin after exposure to ultraviolet rays from sunlight ( Teymoori-Rad et al, 2019 ). The active form of vitamin D, 1,25(OH)D (1,25 dihydroxy vitamin D), binds to the vitamin D receptor (VDR) to play anti-inflammatory and immune regulatory roles ( Gou et al, 2018 , Xiao et al, 2019 ). VDR interacts with 1,25(OH)D and then binds to vitamin D responsive elements (VDREs) to inhibit or promote the expression of target genes, such as enhancement of ACE2 expression ( Cui et al, 2019 ).…”

Section: Could Sars-cov-2-induced Lung Injury Be Attenuated By Vitamimentioning

confidence: 99%

Could SARS-CoV-2-induced lung injury be attenuated by vitamin D?

Xiao

Su³

et al. 2021

International Journal of Infectious Diseases

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Highlights As a counter-regulatory arm of the renin-angiotensin system (RAS), ACE2 plays critical roles in the pathogenesis of ARDS and acute lung injury. The affinity of the spike protein receptor binding domain (RBD) of the SARS-CoV-2 with human ACE2 (hACE2) largely determines the degree of clinical symptoms infected by SARS-CoV-2. Vitamin D was found to affect ACE2, the same target of SARS-CoV-2, we therefore propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 through modulating ACE2.

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The association between vitamin D status and tuberculosis in children

Abstract: This study suggests that vitamin D levels are significantly lower in children with TB/latent TB infection than in controls. TB may contribute to VDD in children. Therefore, VDD may be associated with TB in children.

Cited by 56 publications

References 36 publications

Immune Response to Mycobacterium tuberculosis: A Narrative Review

Immune Response to Mycobacterium tuberculosis: A Narrative Review

Serum vitamin D3 deficiency among cases with extensive tinea corporis infection

Could SARS-CoV-2-induced lung injury be attenuated by vitamin D?

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