The Association Between Zinc and Cognitive Impairment in Elderly People of Iran

Kheirkhah, Farzan; Poorkarim, Kosar; Hosseini, Seyed Reza; Bijani, Ali; Parsian, Hadi; Hamidia, Angela; Korani, Bahare; Faramarzi, Mahbobeh

doi:10.5812/semj.13093

Cited by 8 publications

(11 citation statements)

References 28 publications

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“…Our study noted a positive correlation between plasma zinc concentration and AMTS 8 with respect to overall participants and both men and women (r ¼ 0.31, p < 0.001) (r ¼ 0.35, p < 0.001), and (r ¼ 0.29, p < 0.001) respectively, these observations are in line with Markiewicz et al [27], but is in contrast to the study by Kheirkhah et al [36]. Likewise, a recent study that reported that no association was found between zinc concentration in plasma and global cognitive function [29].…”

Section: Discussionsupporting

confidence: 89%

Zinc status (intake and level) of healthy elderly individuals in Riyadh and its relationship to physical health and cognitive impairment

Alqabbani

Albadr

2020

Clinical Nutrition Experimental

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s u m m a r yObjective: The aim of the current study was to assess the zinc status (intake and level) and its relationship to cognitive impairment among men and women aged 65 years and above in Riyadh, Saudi Arabia. Methods: A cross-sectional single-center study was conducted in 400 participants (200 men and 200 women) aged 65 years and above. They were randomly chosen in the primary care centers in Riyadh. The impaired cognitive functions were measured using the Abbreviated Mental Test Score (AMTS). Plasma zinc concentration was analyzed using an atomic absorption spectrophotometer.Results: The mean plasma zinc concentration was 70 ± 2.34 mg/dL,

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Section: Discussionsupporting

confidence: 89%

Zinc status (intake and level) of healthy elderly individuals in Riyadh and its relationship to physical health and cognitive impairment

Alqabbani

Albadr

2020

Clinical Nutrition Experimental

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“…Nevertheless, a study revealed that advanced PD stage was a risk factor for depressive symptoms in PD patients. 27 Although mental disorders often occur in the elderly with other illnesses, 28 , 29 psychiatric disorders are more frequent in PD patients, especially as the disease progresses. 30…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Symptoms in Patients and Caregivers with Parkinson’s Disease

et al. 2020

Self Cite

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Objectives: Psychiatric disorders in patients with Parkinson’s disease (PD) and their caregivers play an important role in patients’ treatment and follow-up. Our study aimed to examine the prevalence of psychiatric symptoms among patients with PD and their caregivers, demographic risk factors, and the influence of severity and manifestations of PD on psychiatric distress. Methods: We included 125 patients with PD and 125 of their primary caregivers in this descriptive cross-sectional study. The severity of PD was evaluated according to the Hoehn and Yahr severity scale from the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale. PD patients and their caregivers completed the Symptom Checklist-25 to determine the presence of psychiatric distress. Also, demographic factors, including age, high level of education, occupation, residence, and cigarette smoking, were assessed in the PD patients and their caregivers. Results: The prevalence of psychiatric distress was 47.2% for PD patients and 18.4% for caregivers. Female sex, city residency, and medical disease were risk factors for more psychiatric symptoms in PD patients. Also, the female sex, single status, living in a village, and having a medical disease were risk factors for greater psychiatric symptoms in caregivers. PD patients in more advanced stages of disease suffered significantly from psychiatric distress, somatization, anxiety, interpersonal sensitivity, obsessive-compulsive disorder, and phobia compared to the lower severity of disease. PD patients with manifestation of postural instability showed a higher score of somatization, phobia, and psychiatric distress as compared with tremor, hypokinesia, and rigidity. Conclusions: Progression of PD influenced the psychiatric symptoms of both patients and their caregivers. A higher stage of PD is associated with higher scores of psychiatric distress, phobia, and somatization in the patients and their caregivers.

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“…13 In this regard, the results of a study in Iran showed serum zinc level was lower than the normal range at 40.8% of the elderly subjects. 14 With aging populations, age-related health problems will prevail in societies in the near future. Nutritional interventions and effective drug supplements that are used to reduce fatigue in patients and groups are listed as Creatine electrolyte, vitamin B, and a combination of arginine, valine, and serine.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that about 35% to 45% of the elderly over 60 have zinc levels below the normal range 13 . In this regard, the results of a study in Iran showed serum zinc level was lower than the normal range at 40.8% of the elderly subjects 14 . With aging populations, age‐related health problems will prevail in societies in the near future.…”

Section: Introductionmentioning

confidence: 99%

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

Afzali

Goli

Moravveji

et al. 2021

Health Science Reports

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Background and Aims: Fatigue is one of the most common complaints of the elderly.This study was conducted to assess the effect of zinc supplements on fatigue among the elderly.Methods: This randomized clinical trial was conducted on 150 elderly aged ≥60 years who were recruited from the health centers (Kashan, Iran) with a convenience sampling method. Participants were allocated to intervention and control groups by block randomization. Participants in the intervention group received a daily dose of 30 mg of zinc supplement for 70 days; meanwhile, in the control group, no intervention was performed. The level of fatigue was measured by the multidimensional fatigue inventory before and after the intervention. Both groups were homogeneous in terms of demographic variables, fatigue, and serum zinc level before the intervention. The significance level was considered as 0.05 in all tests.Results: Zinc supplementation significantly reduced fatigue (mean difference: À10.41 vs 1.37, P < .001) and increased serum zinc level (mean difference: 14.22, vs À0.57, P < .001) compared to the control group. Conclusion:Consumption of zinc supplements for the elderly is recommended to overcome fatigue.

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The Association Between Zinc and Cognitive Impairment in Elderly People of Iran

Abstract: Background: The association between serum zinc levels and cognitive impairment is a controversial issue. Objectives: The association between serum zinc levels and cognitive impairment was investigated in the elderly population of Amirkola city, northern Iran.

Cited by 8 publications

References 28 publications

Zinc status (intake and level) of healthy elderly individuals in Riyadh and its relationship to physical health and cognitive impairment

Zinc status (intake and level) of healthy elderly individuals in Riyadh and its relationship to physical health and cognitive impairment

Psychiatric Symptoms in Patients and Caregivers with Parkinson’s Disease

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

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